Increased production of autoantibodies and specific antibodies in response to influenza virus vaccination in physically active older individuals

Bachi, André Luís Lacerda; Suguri, Vinícius Magalhães; Ramos, Luiz Roberto; Mariano, Mário; Vaisberg, Mauro; Lopes, José Daniel

doi:10.1016/j.rinim.2013.01.001

Cited by 51 publications

(72 citation statements)

References 26 publications

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“…Thirty women who practiced a regular exercise training program for 1.5 to 5 years and 30 sedentary women, all volunteers, participated in the study, which the Federal University of São Paulo Paulista School of Medicine ethics committee approved. The training protocol that the exercisers performed has been previously described . Sedentary subjects were independent and active but had not practiced regular physical exercise for at least 5 years.…”

Section: Methodsmentioning

confidence: 99%

Exercise Training Improves Plasma Lipid and Inflammatory Profiles and Increases Cholesterol Transfer to High‐Density Lipoprotein in Elderly Women

Bachi

Rocha

Sprandel

et al. 2015

J American Geriatrics Society

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Section: Methodsmentioning

confidence: 99%

Exercise Training Improves Plasma Lipid and Inflammatory Profiles and Increases Cholesterol Transfer to High‐Density Lipoprotein in Elderly Women

Bachi

Rocha

Sprandel

et al. 2015

J American Geriatrics Society

Self Cite

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“…In older adults, those classified as more active show greater antibody responses than their more sedentary counterparts [90, 91]. Data from randomized interventional trials support a causal effect in this relationship.…”

Section: Interventions To Improve Antibody Responses To Vaccinationmentioning

confidence: 99%

Optimizing benefits of influenza virus vaccination during pregnancy: Potential behavioral risk factors and interventions

Christian

2014

Vaccine

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Pregnant women and infants are at high risk for complications, hospitalization, and death due to influenza. It is well-established that influenza vaccination during pregnancy reduces rates and severity of illness in women overall. Maternal vaccination also confers antibody protection to infants via both transplacental transfer and breast milk. However, as in the general population, a relatively high proportion of pregnant women and their infants do not achieve protective antibody levels against influenza virus following maternal vaccination. Behavioral factors, particularly maternal weight and stress exposure, may affect initial maternal antibody responses, maintenance of antibody levels over time (i.e., across pregnancy), as well as the efficiency of transplacental antibody transfer to the fetus. Conversely, behavioral interventions including acute exercise and stress reduction can enhance immune protection following vaccination. Such behavioral interventions are particularly appealing in pregnancy because they are safe and non-invasive. The identification of individual risk factors for poor responses to vaccines and the application of appropriate interventions represent important steps towards personalized health care.

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“…It has also been suggested that these findings have important implications to understand the use of IL-7 and IL-15 as adjuvant for therapeutic vaccination protocols against intracellular pathogens, considering that CD8 + T cells constitute a critical component of protective immunity (Bhadra et al, 2010). Recently, previous regular physical exercise has provided to be an adjuvant in vaccination (Bachi et al, 2013). Besides, it can improve the life quality during the aging process and extend life span (Handschin and Spiegelman, 2008).…”

Section: Discussionmentioning

confidence: 99%

Strength and Aerobic Physical Exercises Are Able to Increase Survival of Toxoplasma gondii-Infected C57BL/6 Mice by Interfering in the IFN-γ Expression

et al. 2016

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Physical exercise has been implicated in several immunophysiological improvements, particularly during the aging process, when an immunocompromised status could be established. Toxoplasma gondii is a protozoan parasite that causes a widespread opportunistic infection, which may present severe consequences, mainly to the fetus and immunocompromised patients. It is estimated that one-third of the human population worldwide has been infected by this parasite, being the reactivation during immunesenescence an unexplored public health issue. The major purpose of the present study was to observe the immunophysiological differences between exercised vs. sedentary C57BL/6 male mice that have been experimentally infected by T. gondii. In the first set of experiments, the animals were infected after exercising and three groups were set up: experimental groups—infected sedentary (IS, n = 6); infected exercised (IEx, n = 6) and control group—non-infected sedentary (NIS, n = 6). When stimulated in vitro by T. gondii-soluble tachyzoite antigen, it was found that splenocytes from exercised group produced higher levels of IFN-γ, as well as of IFN-γ/IL-10 ratios in comparison with splenocytes from sedentary animals (P < 0.001). However, it was not found significant differences concerning quantification of T. gondii genomic DNA by qRT-PCR and immunohistochemistry analysis in brain cysts from both group of animals (P > 0.05). In order to further investigate the consequences of these data for the host, a second set of experiments was performed, when the animals were infected before exercising and four groups of animals were established for comparison purpose, as follows: experimental groups—infected sedentary (IS, n = 7); infected exercised (IEx, n = 6) and control groups—non-infected sedentary (NIS, n = 6) and non-infected exercised (NIEx, n = 6). It was found significant differences in the survival rates of the exercised group the animals, as they survived longer than sedentary groups (P = 0.0005). In both sets of experiments, mice have been submitted to moderate exercises: aerobic (14 m/min; 3 x/week) and strength (60–80% of one maximum repetition; 2 x/week). Overall, our findings are showing that the aerobic and strength exercises are able to modulate immune response against T. gondii infection, being these immunological features beneficial to the host.

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Increased production of autoantibodies and specific antibodies in response to influenza virus vaccination in physically active older individuals

Cited by 51 publications

References 26 publications

Exercise Training Improves Plasma Lipid and Inflammatory Profiles and Increases Cholesterol Transfer to High‐Density Lipoprotein in Elderly Women

Exercise Training Improves Plasma Lipid and Inflammatory Profiles and Increases Cholesterol Transfer to High‐Density Lipoprotein in Elderly Women

Optimizing benefits of influenza virus vaccination during pregnancy: Potential behavioral risk factors and interventions

Strength and Aerobic Physical Exercises Are Able to Increase Survival of Toxoplasma gondii-Infected C57BL/6 Mice by Interfering in the IFN-γ Expression

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