Increased production of natural moisturizing factors and bleomycin hydrolase activity in elderly human skin

Tsurumachi, Munehiro; Kamata, Yoichi; Tominaga, Mitsutoshi; Ishikawa, Junko; Hideshima, Tomoki; Shimizu, Eri; Kaneko, Takahide; Suga, Yasushi; Takamori, Kenji

doi:10.1016/j.jdermsci.2023.03.001

Cited by 5 publications

(6 citation statements)

References 30 publications

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“…Similar results were obtained in negative ion mode. Amino acids are the most important natural moisturizing factors of skin . By the negative t-AP-LDI/PI MSI, abundant aspartic acid ( m / z 132.03, Figure N), sarcosine ( m / z 88.04, Figure S11K), and serine ( m / z 104.03, Figure S11L) were found to be accumulated in the stratum corneum, which suggests the involvement of these amino acids in the balance of skin water.…”

Section: Resultsmentioning

confidence: 99%

Development of Transmission Ambient Pressure Laser Desorption Ionization/Postphotoionization Mass Spectrometry Imaging

Qi,

Lv,

Xiong

et al. 2024

Anal. Chem.

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Laser-based high-resolution mass spectrometry imaging at ambient conditions has promising applications in life science. However, the ion yield during laser desorption/ablation is poor. Here, transmission atmospheric pressure laser desorption ionization combined with a compact postphotoionization (t-AP-LDI/PI) assembly with a krypton discharge lamp was developed for the untargeted imaging of various biomolecules. The spatial distributions of numerous lipid classes, fatty acids, neurotransmitters, and amino acids in the subregions of mouse cerebellum tissue were obtained. Compared with single laser ablation, the sensitivities for most analytes were increased by 1 to 3 orders of magnitude by dopant-assisted postphotoionization. After careful optimization, a spatial resolution of 4 μm could be achieved for the metabolites in mouse hippocampus tissue. Finally, the melanoma tissue slices were analyzed using t-AP-LDI/PI MSI, which revealed the metabolic heterogeneity of the melanoma microenvironment and exhibited the phenomenon of abnormal proliferation and invasion trends in tumor cells.

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Section: Resultsmentioning

confidence: 99%

Development of Transmission Ambient Pressure Laser Desorption Ionization/Postphotoionization Mass Spectrometry Imaging

Qi,

Lv,

Xiong

et al. 2024

Anal. Chem.

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“…In this study, by identifying six amino acids among NMF components that were directly related to in vivo stratum corneum water content, we were able to demonstrate the relationships of these components with age and skin aging. Other NMF-related studies have reported that the total amount of cornified NMF components increases with age [16] [17] [18], which is known to be explained by thickening of the stratum corneum with age [26] [27]. We also selectively examined cornified NMF components only in the middle layer of the stratum corneum; we consider that the levels of these selected NMF components decline with age and may also be associated with signs of skin aging.…”

Section: Discussionmentioning

confidence: 99%

“…Conflicting results have been reported on the relationship between skin aging and stratum corneum NMF levels [16] [17] [18]. The intensity and speed of the aging process differ markedly between individuals [19].…”

Section: Introductionmentioning

confidence: 99%

Six Amino Acids among Natural Moisturizing Factors Responsible for Skin Hydration: Improvement and Anti-Aging of Skin by <i>Galactomyces</i> Ferment Filtrate-Pitera<sup>TM</sup> Containing Skin Moisturizer

Miyamoto,

Munakata,

Fujii

et al. 2024

JCDSA

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Background: Natural moisturizing factors (NMFs) are filaggrin-derived components in the cornified layer that are critical for maintaining healthy skin moisturization and barrier function. However, studies have reported conflicting findings on the relationship between NMF levels and aging, while few studies have investigated this relationship clinically. To fill this research gap, we determined the levels of major NMF components such as free amino acids, pyrrolidone carboxylic acid, and urocanic acids, and individually verified their relationships with skin hydration, barrier function, age, and skin aging. Purpose: The objective of this study was to clinically investigate the relationship between NMF components' levels and skin aging in facial skin. The main NMF components were obtained from facial skin and quantified. We then selected NMF components showing strong relationships to skin hydration, and analyzed the relationships of the levels of these selected NMF components with signs of skin aging, namely, texture, pores, wrinkles, and dullness (L-value). We also examined the efficacy of treatment with a skin care formula (SK-II Facial Treatment Essence, called SK-II FTE hereafter) including Galactomyces ferment filtrate (GFF, Pitera TM ) on the selected NMF component levels associated with skin hydration and barrier function, and the signs of skin aging of texture, pores, wrinkles, and dullness (L-value). Method: We conducted two clinical trials in this research. In Study 1, we measured 23 NMF components using tape-stripped cornified layer to quantify them via an

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“…Logistic regression analysis showed that age, concomitant neurological disease, and stretcher transfer were significantly associated with a higher prevalence of onychomycosis ( p < 0.05), and that male sex and smoking habits were weakly correlated. The skin barrier function is reduced in the elderly 7 . Patients who have a neurological disease or need stretcher transfer, have impaired vision, muscle weakness, and limited limb movement as well as decreased attention to skin condition, resulting in difficulty in performing adequate care of the hands and feet.…”

Section: Discussionmentioning

confidence: 99%

Prevalence and risk factors for onychomycosis in acute care dermatology wards

Inoue,

Watabe,

Furukawa

et al. 2024

The Journal of Dermatology

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We conducted a cross‐sectional study on the clinical and mycological features of onychomycosis in patients in the dermatology ward of Iwate Medical University Hospital, an acute care hospital. Of the 226 hospitalized patients, 73 (32.3%) had onychomycosis and 61 (26.9%) were diagnosed after admission. The toenail was the most common site of onychomycosis (94.5%), while toenail plus fingernail and fingernail only sites were 4.1% and 1.4%, respectively. The most common clinical form of onychomycosis was distal and lateral subungual onychomycosis (79%) with Trichophyton rubrum (66.7%) and T. interdigitale (27.8%) as the main causative species. Patients who were older, or had neurological diseases, or needed stretcher transfer had onychomycosis significantly more frequently than those who were obese, had diabetes, cancer, needed an escort for moving, or could move independently. Our study suggests that there is likely to be a significant number of untreated and undiagnosed patients with onychomycosis in acute care hospitals. Therefore, it is necessary to increase awareness of onychomycosis in hospitals.

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Increased production of natural moisturizing factors and bleomycin hydrolase activity in elderly human skin

Cited by 5 publications

References 30 publications

Development of Transmission Ambient Pressure Laser Desorption Ionization/Postphotoionization Mass Spectrometry Imaging

Development of Transmission Ambient Pressure Laser Desorption Ionization/Postphotoionization Mass Spectrometry Imaging

Six Amino Acids among Natural Moisturizing Factors Responsible for Skin Hydration: Improvement and Anti-Aging of Skin by <i>Galactomyces</i> Ferment Filtrate-Pitera<sup>TM</sup> Containing Skin Moisturizer

Prevalence and risk factors for onychomycosis in acute care dermatology wards

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Increased production of natural moisturizing factors and bleomycin hydrolase activity in elderly human skin

Cited by 5 publications

References 30 publications

Development of Transmission Ambient Pressure Laser Desorption Ionization/Postphotoionization Mass Spectrometry Imaging

Development of Transmission Ambient Pressure Laser Desorption Ionization/Postphotoionization Mass Spectrometry Imaging

Six Amino Acids among Natural Moisturizing Factors Responsible for Skin Hydration: Improvement and Anti-Aging of Skin by &lt;i&gt;Galactomyces&lt;/i&gt; Ferment Filtrate-Pitera&lt;sup&gt;TM&lt;/sup&gt; Containing Skin Moisturizer

Prevalence and risk factors for onychomycosis in acute care dermatology wards

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Product

Resources

About

Six Amino Acids among Natural Moisturizing Factors Responsible for Skin Hydration: Improvement and Anti-Aging of Skin by <i>Galactomyces</i> Ferment Filtrate-Pitera<sup>TM</sup> Containing Skin Moisturizer