Increased production of nitric oxide correlates with tumor growth in Algerian patients with nasopharyngeal carcinoma

Bourouba, Mehdi; Boukercha, Aziza; Zebboudj, Abderezak; Elhadjan, M.; Djenaoui, D.; Asselah, F.; Touil-Boukoffa, Chafia

doi:10.3109/1354750x.2012.706643

Cited by 5 publications

(5 citation statements)

References 47 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Consistent with our previous findings [4], we observed an increase in nitrites in the plasma of NPC patients (n=17) in comparison with the healthy donors (n=8)(29.74±10.22 vs. 21.97±12.26)(Fig. 1A).…”

Section: Resultssupporting

confidence: 93%

“…Our previous studies showed that the TNF-α/NOS2 inflammatory pathway supported tumor growth in-vitro and in patients, and that TNF-α was not the sole responsible for NOS2 activation [4, 5]. We speculated then on the significance of the large differences in nitrite production observed among the tested patients and their possible role in the acquisition of metastatic features or tumor elimination.…”

Section: Discussionmentioning

confidence: 99%

“…These environmental triggers act as inducers of chronic inflammation of the nasopharyngeal tissue and promote cell transformation. The pathology of the NPC tumor microenvironment (TME) is characterized by an 1) important immune cell infiltrates which promote tumor development via the release of a plethora of inflammatory messengers such as cytokines (TNF-α, IL-6), reactive oxygen species (ROS) and nitric oxide (NO) • [4–7] and 2) the synthesis of matrix metalloproteases which support NPC metastatic spread [8]. …”

Section: Introductionmentioning

confidence: 99%

“…In a number of tumors, the pro-tumoral effects directly correlate with the activity of the inducible nitric oxide synthase (NOS2), an aggressive tumor biomarker [16–18]. In NPC patients, nitric oxide synthesis is associated with tumor growth [4]. …”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

IL-6/NOS2 inflammatory signals regulate MMP-9 and MMP-2 activity and disease outcome in nasopharyngeal carcinoma patients

et al. 2015

Self Cite

View full text Add to dashboard Cite

The role of nitric oxide (NO)• in the development of the metastatic properties of nasopharyngeal carcinoma (NPC) is not fully understood. Previous studies proposed that interleukin-6 (IL-6) would act as regulator of matrix metalloprotease activation in NPC. Recently, we showed that (NO)• was a critical mediator of tumor growth in patients. The aim of this study was to determine the implication of IL-6 in the progression of NPC pathology via MMPs activation and their possible correlation with (NO)• production. We observed a significant increase in IL-6 and nitrites (NO2−) synthesis in patients (n=17) as well as a strong expression of IL-6 and nitric oxide synthase 2 (NOS2) in the analyzed tumors (n=8). In patients’ plasma, a negative correlation associated IL-6 with circulating nitrites (r=−0.33). A negative correlation associated the H-scores of these signals in the tumors (r=−0.47). In patients’ plasma, nitrites synthesis was positively associated with MMP-9 activation (r=0.45), pro-MMP-2 expression (r=0.37) and negatively correlated with MMP-2 activation (r=−0.51). High nitrite levels was associated with better recurrence free survival RFS (p=0.02). Overall our results suggest that the IL-6/NOS2 inflammatory signals are involved in the regulation of MMP-9 and MMP-2 dependent metastatic activity, and that high circulating nitrite levels in NPC patients may constitute a prognostic predictor for survival.

show abstract

Section: Resultssupporting

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

IL-6/NOS2 inflammatory signals regulate MMP-9 and MMP-2 activity and disease outcome in nasopharyngeal carcinoma patients

et al. 2015

Self Cite

View full text Add to dashboard Cite

show abstract

“…This free radical is implicated in driving three key factors associated with unfavorable clinical outcomes in cancer: metastasis, resistance to chemo and radiotherapy, and immune suppression [ 8 , 37 , 38 ]. While some studies suggest positive effects of NO [ 39 , 40 , 41 ], the majority link high NOS2 expression to poor survival across a spectrum of hematological and solid tumors, including breast [ 8 ], pancreatic [ 42 ], nasopharyngeal carcinoma [ 43 ], colorectal [ 44 , 45 ], gastric [ 46 ], esophageal [ 47 ], prostate [ 48 ], melanoma [ 49 ], Hodgkin’s lymphoma [ 50 ], ovarian [ 51 ], squamous cell carcinoma [ 52 ], renal cell carcinoma [ 53 ], glioma [ 54 ], chondrosarcomas [ 55 ], Barrett’s esophageal adenocarcinoma [ 56 ], and in HCV-infected liver cancer patients [ 57 ].…”

Section: No In Different Cancer Typesmentioning

confidence: 99%

NOS2 and COX-2 Co-Expression Promotes Cancer Progression: A Potential Target for Developing Agents to Prevent or Treat Highly Aggressive Breast Cancer

Coutinho,

Femino,

Gonzalez

et al. 2024

IJMS

View full text Add to dashboard Cite

Nitric oxide (NO) and reactive nitrogen species (RNS) exert profound biological impacts dictated by their chemistry. Understanding their spatial distribution is essential for deciphering their roles in diverse biological processes. This review establishes a framework for the chemical biology of NO and RNS, exploring their dynamic reactions within the context of cancer. Concentration-dependent signaling reveals distinctive processes in cancer, with three levels of NO influencing oncogenic properties. In this context, NO plays a crucial role in cancer cell proliferation, metastasis, chemotherapy resistance, and immune suppression. Increased NOS2 expression correlates with poor survival across different tumors, including breast cancer. Additionally, NOS2 can crosstalk with the proinflammatory enzyme cyclooxygenase-2 (COX-2) to promote cancer progression. NOS2 and COX-2 co-expression establishes a positive feed-forward loop, driving immunosuppression and metastasis in estrogen receptor-negative (ER-) breast cancer. Spatial evaluation of NOS2 and COX-2 reveals orthogonal expression, suggesting the unique roles of these niches in the tumor microenvironment (TME). NOS2 and COX2 niche formation requires IFN-γ and cytokine-releasing cells. These niches contribute to poor clinical outcomes, emphasizing their role in cancer progression. Strategies to target these markers include direct inhibition, involving pan-inhibitors and selective inhibitors, as well as indirect approaches targeting their induction or downstream effectors. Compounds from cruciferous vegetables are potential candidates for NOS2 and COX-2 inhibition offering therapeutic applications. Thus, understanding the chemical biology of NO and RNS, their spatial distribution, and their implications in cancer progression provides valuable insights for developing targeted therapies and preventive strategies.

show abstract

TNFα antagonization alters NOS2 dependent nasopharyngeal carcinoma tumor growth

et al. 2015

View full text Add to dashboard Cite

Increased production of nitric oxide correlates with tumor growth in Algerian patients with nasopharyngeal carcinoma

Cited by 5 publications

References 47 publications

IL-6/NOS2 inflammatory signals regulate MMP-9 and MMP-2 activity and disease outcome in nasopharyngeal carcinoma patients

IL-6/NOS2 inflammatory signals regulate MMP-9 and MMP-2 activity and disease outcome in nasopharyngeal carcinoma patients

NOS2 and COX-2 Co-Expression Promotes Cancer Progression: A Potential Target for Developing Agents to Prevent or Treat Highly Aggressive Breast Cancer

TNFα antagonization alters NOS2 dependent nasopharyngeal carcinoma tumor growth

Contact Info

Product

Resources

About