Increased Progesterone Production During the Luteal Phase of Menstruation May Decrease Anesthetic Requirement

Erden, Veysel; Yangn, Zehra; Kerem, Eitan; Delatioğlu, Hamdi; Bahçeci, Feyza; Seyhan, Ayşe

doi:10.1213/01.ane.0000168271.76090.63

Cited by 49 publications

(42 citation statements)

References 32 publications

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“…20,21 These depressant and hypnotic effects of progesterone appear to influence the anesthetic requirement in pregnant and non-pregnant patients. 22,23 However, in our term gestation groups, labor did not appear to alter the levels of prolactin or progesterone. Cortisol levels also did not appear to be altered by labor despite the hypothalamopituitary adrenocortical system frequently mediating the response to acute physical and psychological stress.…”

Section: Discussionmentioning

confidence: 54%

The effect of labor on sevoflurane requirements during cesarean delivery

Erden

Kerem

Yangin

et al. 2011

International Journal of Obstetric Anesthesia

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Section: Discussionmentioning

confidence: 54%

The effect of labor on sevoflurane requirements during cesarean delivery

Erden

Kerem

Yangin

et al. 2011

International Journal of Obstetric Anesthesia

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“…Whereas lower levels of testosterone or progesterone have been associated with low nociceptive thresholds, injecting these steroidal hormones has been found to elicit analgesia [251,[256][257][258][259][260]. Several studies have also found that higher levels of progesterone decrease anesthetic [261] and postoperative analgesic requirements [262]. For instance, Lee et al [262] found that parturient women with higher than average serum progesterone levels required less anesthesia and postoperative analgesic during cesarean delivery.…”

Section: Neurosteroidsmentioning

confidence: 99%

Targeting Opioid-Induced Hyperalgesia in Clinical Treatment: Neurobiological Considerations

et al. 2015

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Opioid analgesics have become a cornerstone in the treatment of moderate to severe pain, resulting in a steady rise of opioid prescriptions. Subsequently, there has been a striking increase in the number of opioid-dependent individuals, opioid-related overdoses, and fatalities. Clinical use of opioids is further complicated by an increasingly deleterious profile of side effects beyond addiction, including tolerance and opioid-induced hyperalgesia (OIH), where OIH is defined as an increased sensitivity to already painful stimuli. This paradoxical state of increased nociception results from acute and long-term exposure to opioids, and appears to develop in a substantial subset of patients using opioids. Recently, there has been considerable interest in developing an efficacious treatment regimen for acute and chronic pain. However, there are currently no well-established treatments for OIH. Several substrates have emerged as potential modulators of OIH, including the N-methyl-D-aspartate and γ-aminobutyric acid receptors, and most notably, the innate neuroimmune system. This review summarizes the neurobiology of OIH in the context of clinical treatment; specifically, we review evidence for several pathways that show promise for the treatment of pain going forward, as prospective adjuvants to opioid analgesics. Overall, we suggest that this paradoxical state be considered an additional target of clinical treatment for chronic pain.

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“…A large proportion of women report increases in pain-related symptoms at certain stages of the menstrual cycle [5]. Anesthetic, analgesic, and antiemetic requirements also change across the menstrual cycle [6][7][8]. Several factors have been suggested to explain this situation.…”

Section: Introductionmentioning

confidence: 99%