Increased proteolytic cleavage of osteoglycin is associated with a stable plaque phenotype and lower risk of cardiovascular events

Al-Sharify, Dania; Nielsen, Signe Holm; Matthes, Frank; Tengryd, Christoffer; Sun, Jiangming; Genovese, Federica; Karsdal, Morten A.; Nilsson, Jan; Gonçalves, Isabel; Edsfeldt, Andreas

doi:10.1016/j.atherosclerosis.2022.06.1025

Cited by 2 publications

(2 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A previous study showed that increased carotid plaque concentration of cleaved mimecan was associated with a stable plaque morphology and decreased risk of cardiovascular events, prompting the authors to suggest that mimecan cleavage might reduce cell apoptosis and low‐density lipoprotein retention, and thus represents a potential therapeutic strategy to stabilize the plaques 129 . By contrast, in patients who had acute coronary syndrome or stable angina pectoris, higher circulating mimecan concentration was associated with incident major adverse cardiovascular events during the first year of follow‐up, independently of conventional cardiovascular risk factors 130 .…”

Section: Inflammatory Effects Of Membrane‐bound and Proteolytically C...mentioning

confidence: 99%

Soluble vascular endothelial glycocalyx proteoglycans as potential therapeutic targets in inflammatory diseases

Kunnathattil,

Rahul,

Skaria

2023

Immunol Cell Biol

View full text Add to dashboard Cite

Reducing the activity of cytokines and leukocyte extravasation is an emerging therapeutic strategy to limit tissue‐damaging inflammatory responses and restore immune homeostasis in inflammatory diseases. Proteoglycans embedded in the vascular endothelial glycocalyx, which regulate the activity of cytokines to restrict the inflammatory response in physiological conditions, are proteolytically cleaved in inflammatory diseases. Here we critically review the potential of proteolytically shed, soluble vascular endothelial glycocalyx proteoglycans to modulate pathological inflammatory responses. Soluble forms of the proteoglycans syndecan‐1, syndecan‐3 and biglycan exert beneficial anti‐inflammatory effects by the removal of chemokines, suppression of proinflammatory cytokine expression and leukocyte migration, and induction of autophagy of proinflammatory M1 macrophages. By contrast, soluble versikine and decorin enhance proinflammatory responses by increasing inflammatory cytokine synthesis and leukocyte migration. Endogenous syndecan‐2 and mimecan exert proinflammatory effects, syndecan‐4 and perlecan mediate beneficial anti‐inflammatory effects and glypican regulates Hh and Wnt signaling pathways involved in systemic inflammatory responses. Taken together, targeting the vascular endothelial glycocalyx–derived, soluble syndecan‐1, syndecan‐2, syndecan‐3, syndecan‐4, biglycan, versikine, mimecan, perlecan, glypican and decorin might be a potential therapeutic strategy to suppress overstimulated cytokine and leukocyte responses in inflammatory diseases.

show abstract

Section: Inflammatory Effects Of Membrane‐bound and Proteolytically C...mentioning

confidence: 99%

Soluble vascular endothelial glycocalyx proteoglycans as potential therapeutic targets in inflammatory diseases

Kunnathattil,

Rahul,

Skaria

2023

Immunol Cell Biol

View full text Add to dashboard Cite

show abstract

“…Cleaved osteoglycin is significantly higher in asymptomatic plaques than that in symptomatic plaques, correlating to the histological vulnerability index of plaques. The potential mechanism may be related to reducing cell apoptosis and retaining low-density lipoprotein [ 85 ].…”

Section: Identification Of Vulnerable Plaques At the Microscopic Levelmentioning

confidence: 99%

Identification Markers of Carotid Vulnerable Plaques: An Update

Wang

Luo

2022

Biomolecules

View full text Add to dashboard Cite

Vulnerable plaques have been a hot topic in the field of stroke and carotid atherosclerosis. Currently, risk stratification and intervention of carotid plaques are guided by the degree of luminal stenosis. Recently, it has been recognized that the vulnerability of plaques may contribute to the risk of stroke. Some classical interventions, such as carotid endarterectomy, significantly reduce the risk of stroke in symptomatic patients with severe carotid stenosis, while for asymptomatic patients, clinically silent plaques with rupture tendency may expose them to the risk of cerebrovascular events. Early identification of vulnerable plaques contributes to lowering the risk of cerebrovascular events. Previously, the identification of vulnerable plaques was commonly based on imaging technologies at the macroscopic level. Recently, some microscopic molecules pertaining to vulnerable plaques have emerged, and could be potential biomarkers or therapeutic targets. This review aimed to update the previous summarization of vulnerable plaques and identify vulnerable plaques at the microscopic and macroscopic levels.

show abstract

Increased proteolytic cleavage of osteoglycin is associated with a stable plaque phenotype and lower risk of cardiovascular events

Cited by 2 publications

References 21 publications

Soluble vascular endothelial glycocalyx proteoglycans as potential therapeutic targets in inflammatory diseases

Soluble vascular endothelial glycocalyx proteoglycans as potential therapeutic targets in inflammatory diseases

Identification Markers of Carotid Vulnerable Plaques: An Update

Contact Info

Product

Resources

About