Increased proviral load in HTLV-1-infected patients with rheumatoid arthritis or connective tissue disease

Yakova, Maria; Lézin, Agnès; Dantin, Fabienne; Lagathu, Gisèle; Olindo, Stéphane; Jean-Baptiste, G.; Arfi, S.; Césaire, Raymond

doi:10.1186/1742-4690-2-4

Cited by 72 publications

(25 citation statements)

References 55 publications

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“…Connective tissue diseases, including arthritic conditions and Sjögren's syndrome, have been associated with HAM/TSP [75][76]. Chronic alveolitis was associated with HAM/TSP [77].…”

Section: Ham/tsp Associated Diseasesmentioning

confidence: 96%

HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis (HAM/TSP) Inflammatory Network

Gonçalves¹,

Proietti²,

Barbosa-Stancioli³

et al. 2008

IADT

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| HAM/TSP patients experience impaired functional capacity. The use of categorical scales to accurately describe motor ability in these patients has been questioned. Aim: To evaluate the functional capacity of HAM/TSP patients by using the individual tests comprising the GDLAM protocol. Methods: Cross-sectional study carried out in the CHTLV, Salvador, Brazil. Functional capacity was evaluated using the tests of the GDLAM protocol (timed 10-minute walk, getting up from a sitting position, rising from a prone position, getting up from a chair, and moving around the house). Functional classifications were made by comparing patient performance to that of uninfected control individuals. Results: Twenty-four HAM/TSP and 25 healthy individuals were enrolled. Only 75% HAM/TSP patients completed the GDLAM protocol. Six patients failed to perform the RPP test. Timed measurements were significantly higher in the HAM/ TSP patients in comparison to uninfected controls. Conclusion: The use of alternative methods, such as the individual tests comprising the GDLAM protocol, may more accurately assess motor function in HAM/ TSP patients.

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“…Connective tissue diseases, including arthritic conditions and Sjögren's syndrome, have been associated with HAM/TSP [75][76]. Chronic alveolitis was associated with HAM/TSP [77].…”

Section: Ham/tsp Associated Diseasesmentioning

confidence: 96%

HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis (HAM/TSP) Inflammatory Network

Gonçalves¹,

Proietti²,

Barbosa-Stancioli³

et al. 2008

IADT

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“…A transgenic mice model has supported a role for HTLV-I in chronic arthritis (Yakova et al, 2005). Also, high proviral load is present in the peripheral blood and synovial compartments of HTLV-I-infected patients with rheumatoid arthritis (Yakova et al, 2005).…”

Section: Uveitis Arthritis and Other Autoimmune Diseasesmentioning

confidence: 99%

Global epidemiology of HTLV-I infection and associated diseases

et al. 2005

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“…Human T-lymphotropic virus type 1 (HTLV-1) is a retrovirus responsible for the development of different types of diseases, including adult T-cell leukemia/lymphoma and HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP), in addition to other inflammatory syndromes [1][2][3][4]. Virus infection is endemic in certain regions such as Japan, Australia, Melanesia, the Caribbean, the Middle East, and South America, and it is estimated that 5 to 10 million people are infected worldwide [5].…”

Section: Introductionmentioning

confidence: 99%

TREX1 531C>T Polymorphism is Associated with High Proviral Load Levels in HTLV-1-Infected Persons

Silva

Amoras

Moura

et al. 2019

Viruses

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Human T-lymphotropic virus type 1 (HTLV-1) deregulates the immune system and cell cycle, resulting in loss of immune tolerance and disease, including HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). Three prime repair exonuclease 1 (TREX1) maintains innate immune tolerance of the host and host-cell permissiveness to retroviral infections. TREX1 polymorphisms may influence the course of infection and autoimmune manifestations. The influence of TREX1 531C/T polymorphism was investigated in HTLV-1 infection and development of symptoms among 151 persons infected with HTLV-1 (32 HAM/TSP, 19 rheumatologic manifestations, two dermatitis, five more than one diagnosis, two probable HAM/TSP, and 91 asymptomatic individuals) and 100 uninfected persons in the control group. Polymorphism genotyping and proviral load quantification were performed by real-time polymerase chain reaction (PCR) and antinuclear antibodies (ANAs) were screened by an indirect immunofluorescence assay. No statistically significant difference was found in polymorphism genotype and allele frequencies between the infected and control groups. HAM/TSP patients showed higher frequency of TT genotype than asymptomatic persons (p = 0.0339). Proviral load was significantly higher among individuals with CT/TT genotypes and CC genotype carriers had lower proviral load and higher levels of proinflammatory cytokines. ANAs were present only in the HAM/TSP group. TREX1 531C>T polymorphism seems to be associated with TREX-1 regulation and HTLV-1 infection.

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Increased proviral load in HTLV-1-infected patients with rheumatoid arthritis or connective tissue disease

Cited by 72 publications

References 55 publications

HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis (HAM/TSP) Inflammatory Network

HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis (HAM/TSP) Inflammatory Network

Global epidemiology of HTLV-I infection and associated diseases

TREX1 531C>T Polymorphism is Associated with High Proviral Load Levels in HTLV-1-Infected Persons

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