Increased psoriasis frequency in patients with familial Mediterranean fever

Erden, Abdülsamet; Batu, Ezgi Deniz; Seyhoglu, E.; Sarı, Alper; Sönmez, Hafize Emine; Armağan, Berkan; Kılıç, Levent; Karadağ, Ömer; Akdoğan, Ali; Bılgın, Emre; Ertenli, İhsan; Kiraz, Sedat; Bilgen, Şule Apraş; Kalyoncu, Umut

doi:10.1080/03009734.2017.1423425

Cited by 14 publications

(7 citation statements)

References 24 publications

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“…Inflammasomes play a crucial role in the development of various skin diseases such as psoriasis and HS. 20 In a recent populationbased study by Hodak et al 19 , a strong relationship between HS and FMF has been reported. In this study, there was one HS, one enteropathic arthritis, and three PSA patients.…”

Section: Discussionmentioning

confidence: 93%

Relationship Between Familial Mediterranean Fever and Other Rheumatic Diseases: Coincidence or Coexistence?

Tezcan

Gülcemal

Limon

et al. 2022

Turkish Journal of Internal Medicine

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Background Familial Mediterranean fever (FMF) is the most common monogenic autoinflammatory disease affecting mainly the ethnic groups of the Mediterranean basin. It has been reported that it can coexist with various systemic inflammatory diseases. This study aimed to obtain information on rheumatic diseases that accompany FMF and evaluate the relation between FMF and such diseases. Material and MethodsEighty-four patients diagnosed with FMF and have rheumatic disease comorbidity in the rheumatology clinic between January 2018 -March 2020 were included in this study. ResultsThe most common accompanying rheumatic disease was spondyloarthritis (SpA) with 36 patients. Vasculitis was the second common disease accompanying FMF with 22, followed by connective tissue disease (CTD) in 18, juvenile idiopathic arthritis in 4, gout in 3, and hidradenitis suppurativa in 1 patients. The most common MEFV mutation observed was M694V. The rate of patients in the SPA group with signs of fever was significantly higher than those in the vasculitis group. The median C-reactive protein value of the patients in the vasculitis group was significantly higher than the CTD group. There was no statistically significant difference between disease groups regarding to other clinical manifestations and laboratory findings. There was no statistically significant association between disease groups and MEFV mutations regarding to genotype and allelic distribution. Conclusions In this study, the relation between FMF and various rheumatic diseases was determined. Two new conditions, eosinophilic granulomatous polyangiitis and scleroderma were detected. The associations may be just coincidental or an extension of the common underlying pathology. To be aware of this association is important to early diagnosis and appropriate treatment.

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Section: Discussionmentioning

confidence: 93%

Relationship Between Familial Mediterranean Fever and Other Rheumatic Diseases: Coincidence or Coexistence?

Tezcan

Gülcemal

Limon

et al. 2022

Turkish Journal of Internal Medicine

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“…Concerning psoriasis, there is dearth of evidences, besides anecdotal reports of an association with FMF (8). A study with a sample of 351 FMF found an increased frequency of psoriasis (3.7%) compared to the normal population (26).…”

Section: Discussionmentioning

confidence: 96%

FMF Is Associated With a Wide Spectrum of MHC Class I- and Allied SpA Disorders but Not With Classical MHC Class II-Associated Autoimmune Disease: Insights From a Large Cohort Study

et al. 2019

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Objectives: To test the hypothesis that familial Mediterranean fever (FMF)-associated autoinflammation may exaggerate the tendency toward adaptive immunopathology or spondyloarthritis (SpA)-associated disorders including major histocompatibility complex (MHC) class I associated disorders but not classical MHC class II-associated disorders that exhibit transplacental autoimmunity including myasthenia gravis and pemphigus.Methods: Seven thousand seven hundred forty-seven FMF patients and 10,080 age- and sex-matched controls in the Clalit Health Services medical database were identified and compared in terms of prevalence of SpA-associated disorders. We also evaluated four classical and strong MHC class II-associated disorders, namely, pemphigus vulgaris, myasthenia gravis, sarcoidosis, and pernicious anemia, to ascertain whether such associations with SpA-spectrum disease were specific or merely reflected the non-specific consequences of innate immune system activation on driving divergent types of immunity. The diagnosis of FMF was based on the medical records and not genetically proven.Results: FMF showed a strong association with MHC class I-related diseases: odds ratio (OR) of 28.58 [95% confidence interval (95% CI), 6.93–117.87; p < 0.0001] for Behçet's disease, OR of 10.33 (95% CI, 4.09–26.09; p < 0.0001) for ankylosing spondylitis, and OR of 1.67 (95% CI, 1.19–2.33; p = 0.0029) for psoriasis. For weakly MHC class I-linked diseases, an OR of 3.76 (95% CI, 2.48–5.69; p < 0.0001) for Crohn's disease and OR of 2.64 (95% CI, 1.52–4.56; p = 0.0005) for ulcerative colitis were found. No association was found between FMF and the four MHC class II-associated autoimmune disorders.Conclusion: FMF patients are associated with increased risk of SpA-related disease diagnosis including MHC-I-opathies but not MHC-II-associated autoimmune diseases, suggesting that tissue-specific dysregulation of innate immunity share between FMF and SpA spectrum disorders may drive adaptive immune MHC class I-associated conditions.

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“…Numerous genetic loci have been identified in psoriasis and psoriatic arthritis (18,19). These genetic traits may have an impact on concomitant autoimmune or autoinflammatory diseases (9,10). HLA-C is the strongest HLA-related genetic locus in psoriasis (20).…”

Section: Original Papermentioning

confidence: 99%

“…When psoriasis occurs in patient with rheumatologic diseases, it may have negative effects on the course of the latter. For example, the frequency of abdominal pain and fever is higher in pediatric familial Mediterranean fever patients with psoriasis (9). In addition, psoriasis was found to have a role in poor response to treatment in systemic lupus erythematosus patients (10).…”

mentioning

confidence: 99%

Psoriasis and family history of psoriasis may not affect disease severity of rheumatoid arthritis

et al. 2022

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The incidence of psoriasis in patients with rheumatoid arthritis (RA) is higher than in the general population. In addition, psoriasis may negatively affect the severity of rheumatological diseases in patients with autoinflammatory or autoimmune diseases. In this study, we evaluated the effect of psoriasis or a family history of psoriasis on the characteristics of RA. This is a cross-sectional study. We included 737 RA patients who met the 2010 American College of Rheumatology (ACR)/European League Against Rheumatism (EULAR) RA Classification Criteria, but did not meet the CASPAR psoriatic arthritis criteria. Subsequently, we compared disease activity, the need for biologic therapy, the number of conventional synthetic disease-modifying anti-rheumatic drugs taken, the frequency of erosive disease and extra-articular involvement, glucocorticoid doses and the Stanford Health Assessment Questionnaire scores between patients with and without a history of psoriasis, and patients with and without a family history of psoriasis. Thirteen (1.8%) patients had psoriasis, while 58 (7.9%) had a family history of psoriasis in first- or seconddegree relatives. All outcome parameters were found to be similar between the groups. We show that concomitant psoriasis has no effect on the evaluated disease characteristics of RA.

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Increased psoriasis frequency in patients with familial Mediterranean fever

Cited by 14 publications

References 24 publications

Relationship Between Familial Mediterranean Fever and Other Rheumatic Diseases: Coincidence or Coexistence?

Relationship Between Familial Mediterranean Fever and Other Rheumatic Diseases: Coincidence or Coexistence?

FMF Is Associated With a Wide Spectrum of MHC Class I- and Allied SpA Disorders but Not With Classical MHC Class II-Associated Autoimmune Disease: Insights From a Large Cohort Study

Psoriasis and family history of psoriasis may not affect disease severity of rheumatoid arthritis

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