Increased pulsatility index supports diagnosis of vascular parkinsonism versus idiopathic Parkinson's disease

Caba, L.M.; Ferrairó, José Ignacio Tembl; Torres, I.M.; Vázquez-Costa, Juan Francisco; Muñóz, Rodrigo; Martin, Aaron

doi:10.1016/j.nrleng.2019.06.004

Cited by 2 publications

(2 citation statements)

References 18 publications

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“…Similarly, Tsai et al reported a higher PI with VaP than with PD and controls but with similar intracranial flow velocities [ 58 ]. Another study reported a higher PI with VaP than with PD, supporting its use to confirm the diagnosis of VaP [ 60 ]. Remarkably, average flow velocity showed a correlation with motor (PIGD Off) and cognitive dysfunction (FAB).…”

Section: Discussionmentioning

confidence: 97%

The clinical and neuroimaging differences between vascular parkinsonism and Parkinson’s disease: a case-control study

George,

Roushdy,

Fathy

et al. 2024

BMC Neurol

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Background Parkinson’s disease (PD) and vascular parkinsonism (VaP) have highly overlapping phenotypes, and different prognosis. This study comprehensively investigated the clinical, brain MRI and transcranial sonography differences between VaP and PD. Methods Forty-eight patients with PD, 27 patients with VaP, and 29 healthy controls were compared. All patients were assessed using the MDS-UPDRS, Berg Balance Scale (BBS), Ten-Meter Walking Test (10-MWT), Time Up and Go Test, and Non-Motor Symptoms Scale. Beck Depression Inventory, PD questionnaire- 39, international urine incontinence scale, cognitive assessment scales, MRI brain and transcranial colour-coded doppler. The study was registered on clinical-Trial.gov (NCT04308135) on 03/12/2020. Results VaP patients showed significantly older age of onset, shorter disease duration, lower drug doses and levodopa responsiveness, higher On and Off axial scores, On and Off BBS, higher On scores for PIGD, rigidity, bradykinesia and total motor MDS-UPDRS, lower On and Off tremor, lower-half predominance, lower asymmetrical presentation and symmetric index than PD patients. VaP patients had worse non-motor symptoms Scale (NMSS) than controls except for perceptual problems/hallucinations but better symptoms than PD patients except for urinary dysfunction. Quality of life (QoL) was impaired in VaP patients and was correlated with motor function and NMSs. The VaP group had significantly higher white matter lesions and brain atrophy, with lower hyperechogenicity of the substantia nigra and more impaired cerebral vascular resistance and vasoreactivity than the PD group. Conclusions VaP has a characteristic motor and non-motor profile, with impaired QoL, white matter, and transcranial sonography abnormalities that differentiate it from PD. Further studies are warranted to explore the role of vascular lesions in the pathogenesis of VaP. Trial registration The registered identifier NCT04308135 on clinical-Trial.gov. Registered on 03/12/2020.

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Section: Discussionmentioning

confidence: 97%

The clinical and neuroimaging differences between vascular parkinsonism and Parkinson’s disease: a case-control study

George,

Roushdy,

Fathy

et al. 2024

BMC Neurol

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“…Transcranial Doppler ultrasonography was used for the diagnosis of vascular parkinsonism and its comparison with Parkinson's disease. A higher Gosling index (PI) was observed in VP individuals compared to the PD group (median 29.1 compared to 96.0, p=0.013) (18). This relatively inexpensive and simple test may serve in detecting vascular parkinsonism.…”

Section: Vascular Parkinsonismmentioning

confidence: 88%

The effects that secondary parkinsonian syndromes have on health status

Kościołek,

Urbaś,

Misiak

et al. 2024

J Educ Health Sport

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Introduction and aim of work: The parkinsonian syndrome is a component of Parkinson's disease. A thorough neurological examination can detect symptoms belonging to the parkinsonian syndrome. Diagnosis using the Queen Square Brain Bank criteria is based on the presence of bradykinesia along with one additional symptom in the patient. These include muscle rigidity or resting tremors at a frequency of 4-6 Hz, or postural disturbances that cannot be explained by visual, vestibular, cerebellar, or deep sensory disorders. The parkinsonian syndrome can occur in idiopathic Parkinson's disease, hereditary disorders, secondary parkinsonism, or be part of an atypical parkinsonian syndrome. The aim of the study was to discuss the diagnostic features and differences in the occurrence of the parkinsonian syndrome as a component of Parkinson's disease, both within the context of other neurological disorders. Materials and methods: The foundation of the research was medical articles gathered from the Google Scholar database. The studies were conducted by analyzing keywords such as "parkinsonism," "drug-induced parkinsonism," and "vascular parkinsonism." Results: Secondary parkinsonism, or secondary parkinsonism syndrome, can be indicated by clinical features such as: disease onset below the age of 40, abrupt onset, rapid disease progression, symptoms related to medication use, and symptoms associated with the underlying condition. In addition to clinical evaluation, imaging studies are also employed. Various conditions can lead to the development of secondary parkinsonism, including hydrocephalus, brain tumors, encephalitis, cerebral atherosclerosis, traumatic brain injuries, medications, and poisoning. The aforementioned conditions exert different mechanisms of influence on the central nervous system.

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Increased pulsatility index supports diagnosis of vascular parkinsonism versus idiopathic Parkinson's disease

Cited by 2 publications

References 18 publications

The clinical and neuroimaging differences between vascular parkinsonism and Parkinson’s disease: a case-control study

The clinical and neuroimaging differences between vascular parkinsonism and Parkinson’s disease: a case-control study

The effects that secondary parkinsonian syndromes have on health status

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