Increased pulse-wave velocity and carotid intima–media thickness in patients with lower urinary tract symptoms

Uzun, Hakkı; Çiçek, Yüksel; Kocaman, Sinan Altan; Durakoğlugil, Murtaza Emre; Zorba, Orhan Ünal

doi:10.3109/21681805.2013.780185

Cited by 13 publications

(15 citation statements)

References 31 publications

(56 reference statements)

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“…The results demonstrated that altered baPWV, when controlling for confounders, was associated with DO (right side P = 0.01, left side P = 0.03), suggesting that patients with DO are more likely to have atherosclerosis compared to controls. This is consistent with the one human study on patients with OAB, 7 and previous animal studies. [2][3][4][5] Furthermore, Ponholzer et al 19 demonstrated a correlation between vascular risk factors (hypertension, hyperlipidemia, nicotine use, and diabetes mellitus) and the presence of lower urinary tract symptoms (LUTS).…”

Section: Discussionsupporting

confidence: 93%

Vascular measures of atherosclerosis in detrusor overactivity and controls

Ladanchuk

Kwak

Bates

et al. 2018

Neurourology and Urodynamics

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Section: Discussionsupporting

confidence: 93%

Vascular measures of atherosclerosis in detrusor overactivity and controls

Ladanchuk

Kwak

Bates

et al. 2018

Neurourology and Urodynamics

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“…9 Uzun et al carried out a cross-sectional study to investigate carotid artery IMT in patients with LUTS/OAB. 19 AH, diabetes mellitus (DM), and CVD were exclusion criteria.…”

Section: Discussionmentioning

confidence: 99%

<p>Is There a Link Between Carotid Atherosclerosis and Idiopathic Overactive Bladder Among Women with Metabolic Syndrome?</p>

Schimit

Gregório

Averbeck

et al. 2020

RRU

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Purpose: To evaluate the association between increased intima-media thickness (IMT) and atherosclerotic carotid plaque (CP) with idiopathic overactive bladder syndrome (OAB) in women with metabolic syndrome (MetS). Methods: This is a cross-sectional study, which included consecutive women aged 40-75 years with MetS, seeking medical assistance at a reference center between April and December 2016. OAB-V8 questionnaire was used to estimate the prevalence of OAB symptoms, which were defined by a score ≥8 points. All patients underwent bilateral carotid artery ultrasound to assess IMT and CP. Atherosclerosis was defined by the identification of CP during ultrasound, which was diagnosed according to the Mannheim carotid intimamedia thickness and plaque consensus. Results: Forty-five women were prospectively included. Mean age was 60±9.3 years (range 40-75 ys). Eighteen (40%) patients were diagnosed with OAB. IMT in the general population was 0.72 mm (SD = 0.20). Overall prevalence of atherosclerosis, defined by the presence of the carotid artery plaque, was 51%. OAB prevalence among women with atherosclerosis was higher than in those without atherosclerosis (56.52% versus 22.73%), with a prevalence ratio of 2.49 (p=0.04). Additionally, OAB was associated with degree of carotid stenosis (p = 0.029). Conclusion: In this cohort of female patients with MetS, there was an association between carotid atherosclerosis and OAB. Identification of carotid ultrasound abnormalities may lead to refined treatment decision-making among OAB patients.

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“…In that study, daytime frequency and nocturia were also significantly higher in men with carotid artery atherosclerosis than in those without it (3.1 ± 1.2 times vs. 1.92 ± 1.12 times). Another study that measured the PWV showed that carotid-femoral PWV was significantly higher in men with LUTS after adjustment for age and glucose level 25 . A study with Japanese patients showed similar findings in that the maximum flow rate in men with atherosclerosis assessed by ultrasound examination of the carotid artery was significantly lower than that in the men without it (13.4 ± 5.5 mL/s vs. 16.7 ± 7.7 mL/s).…”

Section: Discussionmentioning

confidence: 99%

Atherosclerosis is associated with erectile function and lower urinary tract symptoms, especially nocturia, in middle-aged men

Tsujimura

Hiramatsu

Aoki

et al. 2017

Prostate International

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BackgroundAtherosclerosis is a systematic disease in which plaque builds up inside the arteries that can lead to serious problems related to quality of life (QOL). Lower urinary tract symptoms (LUTS), erectile dysfunction (ED), and late-onset hypogonadism (LOH) are highly prevalent in aging men and are significantly associated with a reduced QOL. However, few questionnaire-based studies have fully examined the relation between atherosclerosis and several urological symptoms.Materials and methodsThe study comprised 303 outpatients who visited our clinic with symptoms of LOH. Several factors influencing atherosclerosis, including serum concentrations of triglyceride, fasting blood sugar, and total testosterone measured by radioimmunoassay, were investigated. We also measured brachial-ankle pulse wave velocity (baPWV) and assessed symptoms by specific questionnaires, including the Sexual Health Inventory for Men (SHIM), Erection Hardness Score (EHS), International Prostate Symptom Score (IPSS), QOL index, and Aging Male Symptoms rating scale (AMS). Stepwise associations between the ratio of measured/age standard baPWV and clinical factors including laboratory data and the scores of the questionnaires were compared using the Jonckheere–Terpstra test for trend. The associations between the ratio of measured/age standard baPWV and each IPSS score were assessed in a multivariate linear regression model after adjustment for serum triglyceride, fasting blood sugar, and total testosterone.ResultsRegarding ED, a higher level of the ratio of measured/age standard baPWV was associated with a lower EHS, whereas no association was found with SHIM. Regarding LUTS, a higher ratio of measured/age standard baPWV was associated with a higher IPSS and QOL index. However, there was no statistically significant difference between the ratio of measured/age standard baPWV and AMS. A multivariate linear regression model showed only nocturia to be associated with the ratio of measured/age standard baPWV for each IPSS score.ConclusionAtherosclerosis is associated with erectile function and LUTS, especially nocturia.

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Increased pulse-wave velocity and carotid intima–media thickness in patients with lower urinary tract symptoms

Abstract: Vascular impairment was found to be associated with LUTS in both men and women. Atherosclerosis-related vascular risk factors are also known to be related to LUTS and both disorders may have pathogenic interactions.

Cited by 13 publications

References 31 publications

Vascular measures of atherosclerosis in detrusor overactivity and controls

Vascular measures of atherosclerosis in detrusor overactivity and controls

<p>Is There a Link Between Carotid Atherosclerosis and Idiopathic Overactive Bladder Among Women with Metabolic Syndrome?</p>

Atherosclerosis is associated with erectile function and lower urinary tract symptoms, especially nocturia, in middle-aged men

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