Increased recognition of IgA nephropathy in African-American children

Sehic, Azra; Gaber, Lillian W.; Roy, Shane; Miller, P M; Kritchevsky, Stephen B.; Wyatt, Robert

doi:10.1007/s004670050311

Cited by 33 publications

(19 citation statements)

References 11 publications

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“…These differences reflect whether urine-screening programs are performed and the different approaches adopted in obtaining renal biopsy specimens in the various geographic areas [7, 21, 24, 25]. Moreover, Jennette et al [26]reported that the incidence of IgA nephropathy was approximately sixfold lower in blacks in 1985; however, Wyatt et al [19]and Sehic et al [27]reported recently that the incidence of IgA nephropathy was equal or more common in blacks. The prevalence of urinary abnormalities was similar in various geographic areas and races [3, 4], including the present study.…”

Section: Discussionmentioning

confidence: 99%

Prognosis of Asymptomatic Hematuria and/or Proteinuria in Men

Yamagata¹,

Takahashi

Tomida

et al. 2002

Nephron

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Aim: To elucidate prognosis and prevalence of chronic renal diseases among proteinuric and/or hematuric subjects found in mass screening, a long-term follow-up study (6.35 years, range 1.03–14.6 years) was conducted on Japanese working men. Methods: A total of 772 subjects selected from 50,501 Japanese men aged 15–62 years were found to have asymptomatic hematuria (n = 404), concomitant hematuria and proteinuria (n = 155), and proteinuria (n = 213) during their annual urine examination and five consecutive urinalyses. Results: Hematuria patients showed significant improvements in urinary abnormalities as compared with both hematuria/proteinuria and proteinuria patients. Both hematuria/proteinuria patients with normotension and hematuria/proteinuria patients aged under 40 years showed significant improvements. During the follow-up period, 9.5% of the hematuria patients became hematuric/proteinuric. Hematuria/proteinuria patients had the highest risk of developing renal insufficiency. The presence of hypertension at detection of urinary abnormalities did not affect the renal function; however, if proteinuria appeared after the age of 40 years, these patients had a higher risk of developing renal insufficiency. The incidence of IgA nephropathy in the present subjects was as high as 143 cases per 1 million per year. Conclusion: Detailed follow-up and definitive diagnosis of asymptomatic urinary abnormalities may raise the prevalence of IgA nephropathy worldwide.

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Section: Discussionmentioning

confidence: 99%

Prognosis of Asymptomatic Hematuria and/or Proteinuria in Men

Yamagata¹,

Takahashi

Tomida

et al. 2002

Nephron

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“…Because our department provides all third round school urinalysis screening and performs all pediatric renal biopsies in Nishinomiya City, Hyogo Prefecture, we are aware of nearly all cases of pediatric IgA nephropathy diagnosed in Nishinomiya City. Table 6 provides literature citations for the number of cases of pediatric IgA nephropathy per 100,000 children in the pediatric population [4][5][6][7]. The age range of the patients in each study exhibits some variation, rendering comparison difficult.…”

Section: Discussionmentioning

confidence: 99%

Epidemiological survey and clinical investigation of pediatric IgA nephropathy

et al. 2015

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Our study found that 9.9 cases of pediatric IgA nephropathy were diagnosed per 100,000 in the pediatric population, which is equivalent to or slightly more than past reports. IgA nephropathy, which poses a high histologic risk, presents with heavy proteinuria; but the proteinuria remission rate following steroid therapy is high 3 years after treatment, which suggests that administration of steroids results in an improved clinical outcome.

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“…Although some centers have reported that IgAN was rare in AA cohorts (4 -7), others have shown incidence rates in Caucasians and AA populations to be similar (8,21). Data from the African American Study of Kidney Disease also suggest that IgAN may be rare in African Americans (22).…”

Section: Discussionmentioning

confidence: 99%

Galactose-Deficient IgA1 in African Americans with IgA Nephropathy

Hastings¹,

Moldoveanu²,

Julian³

et al. 2010

Clinical Journal of the American Society of Nephrology

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Background and objectives: Serum levels of galactose-deficient IgA1 (Gd-IgA1) are elevated and heritable in Caucasian and Asian patients with IgA nephropathy (IgAN), but have not been characterized in African Americans (AA). Our objective was to determine whether serum Gd-IgA1 levels are increased in AA patients with IgAN and whether this is a heritable trait in this group.Design, setting, participants, & measurements: Blood and urine samples were obtained from 18 adult and 11 pediatric AA patients with biopsy-proven IgAN and from 34 of their first-degree relatives. Healthy controls included 150 Caucasian adults, 65 AA adults, 45 Caucasian children, and 49 AA children. Serum total IgA and Gd-IgA1 levels were measured in patients and controls. Significant differences between patient and control groups for serum total IgA, Gd-IgA1, and ratio of Gd-IgA1/total IgA were determined by the Mann-Whitney U test. Heritability was calculated using SOLAR.Results: After stratifying by age, 7 of 11 pediatric and 9 of 18 adult AA patients with IgAN had serum Gd-IgA1 levels above the 95th percentile for age-appropriate AA controls. For first-degree relatives, the serum Gd-IgA1 level was >95th percentile for 1 of 8 when the patient's level was <95th percentile and 12 of 26 when the patient's level was >95th percentile (P ‫؍‬ 0.116, Fisher exact test). Heritability was 0.74 (P ‫؍‬ 0.007).Conclusions: Serum levels of Gd-IgA1 are often elevated in AA patients with IgAN and their first-degree relatives. Thus, aberrant IgA1 glycosylation is a heritable risk factor for IgAN in African Americans.

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Increased recognition of IgA nephropathy in African-American children

Cited by 33 publications

References 11 publications

Prognosis of Asymptomatic Hematuria and/or Proteinuria in Men

Prognosis of Asymptomatic Hematuria and/or Proteinuria in Men

Epidemiological survey and clinical investigation of pediatric IgA nephropathy

Galactose-Deficient IgA1 in African Americans with IgA Nephropathy

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