Increased replication of HTLV‐I in HTLV‐I–associated myelopathy

Yoshida, Mitsuaki; Osame, Mitsuhiro; Kawai, Hisaomi; Toita, Masami; Kuwasaki, N; Nishida, Yoshihiko; Hiraki, Yukako; Takahashi, Kyôko; Nomura, Koichiro; Sonoda, Shunro; Eiraku, Nobutaka; Ijichi, Shinji; Usuku, Koichiro

doi:10.1002/ana.410260304

Cited by 162 publications

(81 citation statements)

References 18 publications

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“…23 On the other hand, naive T cells in CD4 ϩ and CD8 ϩ subpopulations were markedly decreased in these patients (Figures 1 and 2). In HTLV-I carriers, and patients with HAM/TSP, who are known to have high provirus loads, 24 naive T lymphocytes were also decreased, similar to patients with ATL although the extent of such decrease was milder. These findings indicate that HTLV-I-infected individuals have a low proportion of naive T lymphocytes and high memory T lymphocytes.…”

Section: Flow Cytometric Analysis Of T Lymphocytes In Htlv-i-infectedmentioning

confidence: 90%

Impaired production of naive T lymphocytes in human T-cell leukemia virus type I–infected individuals: its implications in the immunodeficient state

Yasunaga

Sakai

Nosaka

et al. 2001

Blood

139

102

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Section: Flow Cytometric Analysis Of T Lymphocytes In Htlv-i-infectedmentioning

confidence: 90%

Impaired production of naive T lymphocytes in human T-cell leukemia virus type I–infected individuals: its implications in the immunodeficient state

Yasunaga

Sakai

Nosaka

et al. 2001

Blood

139

102

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“…[39][40][41][42] Monoclonal proliferation of the HTLV-1-infected cells has been shown to occur in coinfected patients but not in asymptomatic HTLV-1 carriers who do not have strongyloidiasis. 43,44 Furthermore, the results of a recent study have shown that the Strongyloides antigen is implicated in T-cell proliferation and ultimately accelerates leukemogenesis. 37 Successful treatment of strongyloidiasis may reverse clonal expansion by decreasing the HTLV-1 proviral load.…”

Section: Risk Factors For Disseminationmentioning

confidence: 99%

Complicated and fatal Strongyloides infection in Canadians: risk factors, diagnosis and management

Lim¹

2004

Canadian Medical Association Journal

159

173

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STRONGYLOIDIASIS, WHICH IS CAUSED by the nematode Strongyloides stercoralis, is a common and persistent infection, particularly in developing countries. In the setting of compromised cellular immunity, it can result in fulminant dissemination with case-fatality rates of over 70%. The majority of new Canadian immigrants come from countries where Strongyloides is highly endemic; therefore, the burden of Strongyloides may be underappreciated in Canada. Because early diagnosis and therapy can have a marked impact on disease outcome, screening for this infection should be considered mandatory for patients who have a history of travel or residence in a disease-endemic area and risk factors for disseminated disease (e.g., corticosteroid use and human Tlymphotropic virus type I infection).

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“…It has been previously demonstrated that the replication of HTLV-I is increased in HAM/TSP patients as compared with asymptomatic HTLV-I carriers (10,11). However, this is not yet conclusive and the mechanisms of HAM/TSP development still continue to elude us.…”

mentioning

confidence: 99%

Human T-cell lymphotropic virus type I (HTLV-I) proviral DNA viral load among asymptomatic patients and patients with HTLV-I-associated myelopathy/tropical spastic paraparesis

Montanheiro

Oliveira

Vergara

et al. 2005

Braz J Med Biol Res

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To evaluate the human T-cell lymphotropic virus type I (HTLV-I) proviral DNA load among asymptomatic HTLV-I-infected carriers and patients with HTLV-I-associated myelopathy/tropical spastic paraparesis (HAM/TSP), real time PCR using TaqMan probes for the pol gene was performed in two million peripheral blood mononuclear cells (PBMC). The albumin gene was the internal genomic control and MT2 cells were used as positive control. The results are reported as copies/10,000 PBMC, and the detection limit was 10 copies. A total of 89 subjects (44 HAM/TSP and 45 healthy HTLV-I-infected carriers) followed up at the Institute of Infectious Diseases "Emilio Ribas" and in the Neurology Division of Hospital of Clínicas were studied. The asymptomatic HTLV-I-infected carriers had a median number of 271 copies (ranging from 5 to 4756 copies), whereas the HAM/TSP cases presented a median of 679 copies (5-5360 copies) in 10,000 PBMC. Thus, HAM/TSP patients presented a significantly higher HTLV-I proviral DNA load than healthy HTLV-I carriers (P = 0.005, one-way Mann-Whitney test). As observed in other persistent infections, proviral DNA load quantification may be an important tool for monotoring HTLV-I-infected subjects. However, long-term follow-up is necessary to validate this assay in the clinical setting.

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Increased replication of HTLV‐I in HTLV‐I–associated myelopathy

Cited by 162 publications

References 18 publications

Impaired production of naive T lymphocytes in human T-cell leukemia virus type I–infected individuals: its implications in the immunodeficient state

Impaired production of naive T lymphocytes in human T-cell leukemia virus type I–infected individuals: its implications in the immunodeficient state

Complicated and fatal Strongyloides infection in Canadians: risk factors, diagnosis and management

Human T-cell lymphotropic virus type I (HTLV-I) proviral DNA viral load among asymptomatic patients and patients with HTLV-I-associated myelopathy/tropical spastic paraparesis

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