Increased resistin blood levels are not associated with insulin resistance in patients with renal disease

Kielstein, Jan T.; Becker, Björn; Gräf, Susanne; Brabant, Georg; Haller, Hermann; Fliser, Danilo

doi:10.1016/s0272-6386(03)00409-8

Cited by 114 publications

(108 citation statements)

References 16 publications

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“…This finding extends the settings into which the association between resistin and eGFR is observed, such as chronic kidney disease, type 2 diabetes and coronary heart disease. 8,20,21 Reduced eGFR in hypertensive subjects can be considered a consequence of preglomerular microvasculopathy. 22,23 In this context, resistin augments the expression of endothelin, adhesion molecules, matrix metalloproteinases, promoting systemic vascular dysfunction, unfavourably affecting eGFR.…”

Section: Discussionmentioning

confidence: 99%

Independent association of circulating resistin with glomerular filtration rate in the early stages of essential hypertension

et al. 2009

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Resistin, a newly discovered protein, promotes endothelial dysfunction and proinflammatory activation, contributing to subclinical atherosclerosis in different clinical settings. In this study we sought to investigate the relationship of increased resistin levels with estimated glomerular filtration rate (eGFR), the most established marker of kidney impairment, in hypertensive subjects. Our population consisted of 132 untreated non-diabetic subjects with stage I-II essential hypertension (49 males, mean age ¼ 54 years, office blood pressure (BP) ¼ 159/100 mm Hg). In all patients eGFR was assessed by the Modification in Renal Disease equation and venous blood sampling was performed for estimation of resistin concentrations. The distribution of resistin was split by the median (4.63 ng ml À1 ) and accordingly subjects were stratified into those with high and low values. Hypertensive patients with high (n ¼ 66) compared to those with low resistin (n ¼ 66) exhibited lower eGFR values (77.1±9.4 vs 89.1±12.2 ml min À1 per 1.73m 2 , Po0.0001), even after adjustment for established confounders. In the total population, resistin was associated with 24-h systolic BP (r ¼ 0.244, Po0.05), serum creatinine (r ¼ 0.311, P ¼ 0.007) and eGFR (r ¼ À0.519, Po0.0001). Multiple regression analysis revealed that age (b ¼ 0.379, P ¼ 0.01), body mass index (b ¼ 0.158, P ¼ 0.022), 24-h systolic BP (b ¼ 0.284, P ¼ 0.006) and resistin (b ¼ 0.429, Po0.0001) were independent predictors of eGFR (R 2 ¼ 0.436, Po0.0001). In essential hypertensive subjects, higher resistin levels are associated with renal function impairment, as reflected by decreased eGFR. Moreover, the independent association of resistin with eGFR suggests involvement of resistin in the progression of kidney damage in the early stages of hypertension.

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Section: Discussionmentioning

confidence: 99%

Independent association of circulating resistin with glomerular filtration rate in the early stages of essential hypertension

et al. 2009

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“…There are substantial inter-species differences between the sites of resistin production, occurring, for example, in adipocytes in rodents, and most likely non-fat cells, macrophages or other stromal cells present in the adipose tissue in humans [63][64][65][66]. The role of resistin in humans is not well established, since clinical studies do not show a clear link between obesity and insulin resistance versus resistin levels [67,68]. Angiopoietin-like proteins (ANGPTLs) are also involved in the regulation of energy homeostasis [69].…”

Section: Adipokines Directly Involved In Energy Homeostasismentioning

confidence: 99%

Fat poetry: a kingdom for PPARγ

2007

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Adipose tissue is not an inert cell mass contributing only to the storage of fat, but a sophisticated ensemble of cellular components with highly specialized and complex functions. In addition to managing the most important energy reserve of the body, it secretes a multitude of soluble proteins called adipokines, which have beneficial or, alternatively, deleterious effects on the homeostasis of the whole body. The expression of these adipokines is an integrated response to various signals received from many organs, which depends heavily on the integrity and physiological status of the adipose tissue. One of the main regulators of gene expression in fat is the transcription factor peroxisome proliferatoractivated receptor g (PPARg), which is a fatty acid-and eicosanoid-dependent nuclear receptor that plays key roles in the development and maintenance of the adipose tissue. Furthermore, synthetic PPARg agonists are therapeutic agents used in the treatment of type 2 diabetes.This review discusses recent knowledge on the link between fat physiology and metabolic diseases, and the roles of PPARg in this interplay via the regulation of lipid and glucose metabolism. Finally, we assess the putative benefits of targeting this nuclear receptor with still-to-be-identified highly selective PPARg modulators.

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“…4,5 In crosssectional studies in adulthood, serum resistin was reported to be related to fat mass [6][7][8] and to insulin resistance, [9][10][11][12] while other reports reveal no correlations to BMI, percent body fat 11,[13][14][15] or to insulin sensitivity. 13,14,16,17 Longitudinal data are necessary to analyze the relationships between resistin, obesity, and insulin resistance. Despite the great number of cross-sectional studies, there are only few longitudinal studies in adulthood with small numbers of subjects concerning resistin levels in obesity with contradictory results.…”

Section: Introductionmentioning

confidence: 99%

Resistin concentrations before and after weight loss in obese children

et al. 2005

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Objective: The influences of gender, puberty, and obesity on resistin levels and the longitudinal relationships between insulin resistance, weight loss, and resistin have not yet been studied in childhood. Methods: Age, pubertal stage, gender, weight status (standard deviation score-body mass index (SDS-BMI)), resistin levels, and insulin resistance index calculated by homeostasis model assessment (HOMA) were evaluated in 63 obese children and compared to 36 lean children of same age, gender, and pubertal stage. Furthermore, we analyzed the changes of weight status (SDS-BMI, percentage body fat based on skinfold measurements), waist-to-hip ratio, resistin, and HOMA over a 1-year period in 38 obese children. Results: The resistin levels did not significantly (P ¼ 0.079) differ between obese (median resistin 8.7 ng/ml) and lean children (median resistin 9.7 ng/ml). Resistin concentrations were independent of age and pubertal stage, but girls demonstrated significantly higher resistin levels than boys (P ¼ 0.021). There were no significant correlations between changes of resistin and changes of SDS-BMI (r ¼ 0.14, P ¼ 0.198), changes of percentage body fat (r ¼ À0.01, P ¼ 0.466), changes of waist-to-hip ratio (r ¼ 0.17, P ¼ 0.141), and changes of insulin resistance index (r ¼ 0.01, P ¼ 0.472) over the 1-year period. The weight loss of X0.5 SDS-BMI in 16 children was associated with a significant decrease in HOMA (P ¼ 0.030), while there was no significant change in resistin levels (P ¼ 0.878). Conclusions: Girls demonstrated higher resistin concentrations than boys. Our data do not support a relationship between resistin, insulin resistance index, and weight status in childhood.

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Increased resistin blood levels are not associated with insulin resistance in patients with renal disease

Cited by 114 publications

References 16 publications

Independent association of circulating resistin with glomerular filtration rate in the early stages of essential hypertension

Independent association of circulating resistin with glomerular filtration rate in the early stages of essential hypertension

Fat poetry: a kingdom for PPARγ

Resistin concentrations before and after weight loss in obese children

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