Increased resting-state EEG functional connectivity in benign childhood epilepsy with centro-temporal spikes

Clemens, Béla; Puskás, Szilvia; Spisák, Tamás; Lajtos, Imre; Opposits, Gábor; Besenyei, Mónika; Hollódy, Katalin; Fogarasi, András; Kovács, Noémi Zsuzsanna; Fekete, István; Emri, Miklós

doi:10.1016/j.seizure.2016.01.001

Cited by 26 publications

(22 citation statements)

References 46 publications

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“…An additional limitation is that IEDs appear to significantly affect functional connectivity measurements. Nearly all studies accounting for the presence of IEDs have observed a relationship between the IEDs and connectivity patterns . Similarly, graph theory analyses also suggest widespread effects of IEDs .…”

Section: Discussionmentioning

confidence: 94%

“…Nearly all studies accounting for the presence of IEDs have observed a relationship between the IEDs and connectivity patterns. 13,48,49,52,54,[61][62][63] Similarly, graph theory analyses also suggest widespread effects of IEDs. 94 Brief alterations in neurophysiological signals, including both blood oxygen level-dependent contrast imaging and electromagnetic measurements, will inherently change the time-course correlations between affected and remote brain regions.…”

Section: Discussionmentioning

confidence: 96%

“…Electrographic measures suggest an overall increase in the connectivity within frontal and frontotemporal regions that appears to be partly driven by the IEDs. 48,49 The orbitofrontal cortex (OFC) in particular has repeatedly shown disease-related variations, with decreased regional homogeneity (ReHo) values, 27 less dynamic | 1501 BEAR Et Al variability, 20 and greater isolation from other networks. 33 This latter pattern has also been observed in a study reporting greater anticorrelation between the DMN and executive networks.…”

Section: Executive Functioning and The Frontal Lobementioning

confidence: 99%

“…33 This latter pattern has also been observed in a study reporting greater anticorrelation between the DMN and executive networks. 17 Both increases and decreases of connectivity within frontal regions are reported, 17,18,33,49 with the variability likely being related to choice of analytical method and specific ROIs. Finally, decreased within-network connectivity involving the dorsal attention network is also reported.…”

Section: Executive Functioning and The Frontal Lobementioning

confidence: 99%

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The epileptic network and cognition: What functional connectivity is teaching us about the childhood epilepsies

2019

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Our objective was to summarize and evaluate the rapidly expanding body of literature studying functional connectivity in childhood epilepsy. In the self‐limited childhood epilepsies, awareness of cognitive comorbidities has been steadily increasing, and recent advances in our understanding of the network effects of these disorders promise insights into the underlying neurobiology. We reviewed publications addressing functional connectivity in children with epilepsy with an emphasis on studies of children with self‐limited childhood epilepsies. The majority of studies have been published in the past 10 years and predominantly examine childhood epilepsy with centrotemporal spikes and childhood absence epilepsy. Cognitive network alterations are commonly observed across the childhood epilepsies. Some of these effects appear to be nonspecific to epilepsy syndrome or even to category of neurological disorder. Other patterns, such as changes in the connectivity of cortical language areas in childhood epilepsy with centrotemporal spikes, provide clues to the underlying cognitive deficits seen in affected children. The literature to date is dominated by general observations of connectivity patterns without a priori hypotheses. These data‐driven studies build an important foundation for hypothesis generation and are already providing useful insights into the neuropathology of the childhood epilepsies. Future work should emphasize hypothesis‐driven approaches and rigorous clinical correlations to better understand how the knowledge of network alterations can be applied to guidance and treatment for the children in our clinics.

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Section: Discussionmentioning

confidence: 94%

Section: Discussionmentioning

confidence: 96%

Section: Executive Functioning and The Frontal Lobementioning

confidence: 99%

Section: Executive Functioning and The Frontal Lobementioning

confidence: 99%

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The epileptic network and cognition: What functional connectivity is teaching us about the childhood epilepsies

2019

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“…Of the wide variety of imaging modalities used for functional connectivity, scalp electroencephalogram (EEG) is desirable due to its accessibility, low cost, standardized clinical application, noninvasive nature, and high temporal resolution. EEG-based FCNs have been used to characterize pathological networks associated with temporal lobe epilepsy (Quraan et al 2013), benign epilepsy with centrotemporal spikes (Clemens et al 2016;Mahmoudzadeh et al 2016), and generalized pharmacoresistant epilepsies (Horstmann et al 2010). When these FCNs are based on cross-correlation or coherence techniques using at least 100 seconds of EEG data, the networks exhibit stability over time, making them suitable for assessing an underlying disease state (Chu-Shore et al 2012).…”

Section: Introductionmentioning

confidence: 99%

Effect of interictal epileptiform discharges on EEG-based functional connectivity networks

Hu¹,

Shrey²,

Lopour³

2019

Preprint

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Objective: Functional connectivity networks (FCNs) based on interictal electroencephalography (EEG) can identify pathological brain networks associated with epilepsy. FCNs are altered by interictal epileptiform discharges (IEDs), but it is unknown whether this is due to the morphology of the IED or the underlying pathological activity. Therefore, we characterized the impact of IEDs on the FCN through simulations and EEG analysis. Methods:We introduced simulated IEDs to sleep EEG recordings of eight healthy controls and analyzed the effect of IED amplitude and rate on the FCN. We then generated FCNs based on epochs with and without IEDs and compared them to the analogous FCNs from eight subjects with infantile spasms (IS), based on 1,340 visually marked IEDs. Differences in network structure and strength were assessed.Results: IEDs in IS subjects caused increased connectivity strength but no change in network structure. In controls, simulated IEDs with physiological amplitudes and rates did not alter network strength or structure. Conclusions:Increases in connectivity strength in IS subjects are not artifacts caused by the interictal spike waveform and may be related to the underlying pathophysiology of IS.Significance: Dynamic changes in EEG-based FCNs during IEDs may be valuable for identification of pathological networks associated with epilepsy.Epilepsy, infantile spasms, electroencephalography, functional connectivity, interictal epileptiform discharges, brain mapping Hu 3 Highlights:• Infantile spasms subjects exhibit broadly increased connectivity strength during interictal spikes • Functional connectivity network structure is unaltered by interictal spikes in infantile spasms • Simulated spikes in healthy control EEG did not alter network strength or structure

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Electro‐Clinical Features and Functional Connectivity Analysis in SYN1‐Related Epilepsy

Moya Quiros,

Adham,

Convers

et al. 2024

Annals of Neurology

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ObjectiveThere is currently scarce data on the electroclinical characteristics of epilepsy associated with synapsin 1 (SYN1) pathogenic variations. We examined clinical and electro‐encephalographic (EEG) features in patients with epilepsy and SYN1 variants, with the aim of identifying a distinctive electroclinical pattern.MethodsIn this retrospective multicenter study, we collected and reviewed demographic, genetic, and epilepsy data of 19 male patients with SYN1 variants. Specifically, we analyzed interictal EEG data for all patients, and electro‐clinical data from 10 epileptic seizures in 5 patients, using prolonged video‐EEG monitoring recordings. Inter‐ictal EEG functional connectivity parameters and frequency spectrum of the 10 patients over 12 years of age, were computed and compared with those of 56 age‐ and sex‐matched controls.ResultsThe main electroclinical features of epilepsy in patients with SYN1 were (1) EEG background and organization mainly normal; (2) interictal abnormalities are often rare or not visible on EEG; (3) more than 60% of patients had reflex seizures (cutaneous contact with water and defecation being the main triggers) isolated or associated with spontaneous seizures; (4) electro‐clinical semiology of seizures was mainly temporal or temporo‐insulo/perisylvian with a notable autonomic component; and (5) ictal EEG showed a characteristic rhythmic theta/delta activity predominating in temporo‐perisylvian regions at the beginning of most seizures. Comparing patients with SYN1 to healthy subjects, we observed a shift to lower frequency bands in power spectrum of interictal EEG and an increased connectivity in both temporal regions.InterpretationA distinct epilepsy syndrome emerges in patients with SYN1, with a rather characteristic clinical and EEG pattern suggesting predominant temporo‐insular involvement. ANN NEUROL 2024

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Increased resting-state EEG functional connectivity in benign childhood epilepsy with centro-temporal spikes

Abstract: Areas of increased EEGfC topographically correspond to cortical areas that, based on relevant literature, are related to speech and attention deficit in BECTS children.

Cited by 26 publications

References 46 publications

The epileptic network and cognition: What functional connectivity is teaching us about the childhood epilepsies

The epileptic network and cognition: What functional connectivity is teaching us about the childhood epilepsies

Effect of interictal epileptiform discharges on EEG-based functional connectivity networks

Electro‐Clinical Features and Functional Connectivity Analysis in SYN1‐Related Epilepsy

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