Increased reversal and oscillatory shear stress cause smooth muscle contraction‐dependent changes in sheep aortic dynamics: role in aortic balloon pump circulatory support

Bia, Daniel; Zócalo, Yanina; Armentano, Ricardo L.; Camús, Juan; Forteza, Eduardo de; Cabrera-Fischer, Edmundo I.

doi:10.1111/j.1748-1716.2007.01765.x

Cited by 28 publications

(45 citation statements)

References 35 publications

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“…Loss of normal endothelial functions may contribute to various vascular pathologies and aneurysmal ruptures [50,57,58,59]. Similarly, high OSI, which represents quick changes in the direction of WSS, is also associated with endothelial damage and aneurysm formation, progression, thrombosis and/or rupture [60,61,62,63]. There is evidence that ruptured intracranial aneurysms are associated with higher OSI than unruptured aneurysms [48].…”

Section: Discussionmentioning

confidence: 99%

Hemodynamic Analysis of Intracranial Aneurysms with Daughter Blebs

Zhang

Chen

et al. 2011

Eur Neurol

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Background and Purpose: Intracranial aneurysms with daughter blebs appear to have a higher risk of rupture. Whether hemodynamic factors are involved in this phenomenon is not clear. Methods: 54 patient-specific aneurysms harboring 69 daughter blebs were divided into ruptured and unruptured groups based on their clinical history. Realistic models were retrospectively constructed and analyzed by a computational fluid dynamic method. Results: There were no differences in the aspect ratio and morphology type of the aneurysms, the size of blebs or other common risk factors between the two groups. The wall shear stress (WSS) was significantly lower while the oscillatory shear index (OSI) was higher in the daughter blebs than in the primary aneurysms. Bleb-bearing aneurysms with a rupture history displayed significantly lower WSS in the daughter bleb. Of the daughter blebs, 73.9% were localized to the impingement region of the inflow jet. Conclusion: These observations indicate that low WSS and high OSI in the daughter blebs might be involved in increasing the risk of rupture. The localized striking force caused by inflow jets may contribute to the development of daughter blebs. However, a precise role of hemodynamics in predicting the future rupture of daughter blebs needs further study.

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Section: Discussionmentioning

confidence: 99%

Hemodynamic Analysis of Intracranial Aneurysms with Daughter Blebs

Zhang

Chen

et al. 2011

Eur Neurol

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“…Consequently, it was postulated that at medium and long term, oscillatory mean WSS exerts deleterious effects on the arterial wall, establishing a connection between reversal flow and vascular diseases. 25 In 9 pairs of the MANs that we explored, OSI was much higher in the ruptured group compared with the unruptured group. The mean OSI of the ruptured group was 0.0766 Ϯ 0.0630, which was 4 times higher than that of the unruptured group (0.0139 Ϯ 0.0168).…”

Section: Osimentioning

confidence: 99%

Influence of Hemodynamic Factors on Rupture of Intracranial Aneurysms: Patient-Specific 3D Mirror Aneurysms Model Computational Fluid Dynamics Simulation

Lü¹,

Huang²,

Zhang³

et al. 2011

AJNR Am J Neuroradiol

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“…First, the geometrical (i.e. aortic and peripheral dilatation) and biomechanical changes (isobaric arterial stiffness reduction) agree with a vascular smooth muscle relaxation pattern [11]. Second, the changes in the arterial load determinants were associated with the changes in aortic blood flow levels [ Figure 2].…”

Section: Resultsmentioning

confidence: 95%

Cardiac resynchronization results in aortic blood flow-associated changes in the arterial load components: Basal biomechanical conditions determine the load changes

Zócalo

González-Moreno

Torrado

et al. 2009

2009 Annual International Conference of the IEEE Engineering in Medicine and Biology Society

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The cardiac resynchronization therapy (CRT) effects on the arterial load components, the mechanisms (i.e. haemodynamic changes-dependence) involved in the load reduction and the factors (i.e. basal load conditions) associated with the load changes after CRT, are to be evaluated. Aims: a) to analyze the potential changes in the arterial load components (peripheral resistances, arterial compliance and impedance) associated with the CRT, b) to determine if the load components changes are associated with variations in haemodynamic variables (pressure, heart rate or blood flow), c) to analyze the relationship between the load components basal state and their changes after CRT. To fulfill these aims cardiac and arterial structural and mechanical parameters were non-invasively evaluated in 8 heart failure patients, pre-and post-CRT (23±8 days). The main results were that short-term after CRT: 1) there were changes in the static and dynamic determinants of the arterial load; 2) the changes in the load components were not associated with heart rate or pressure variations, but with blood flow changes, and 3) the load components basal levels and their changes after CRT were associated.

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Increased reversal and oscillatory shear stress cause smooth muscle contraction‐dependent changes in sheep aortic dynamics: role in aortic balloon pump circulatory support

Abstract: In addition to pressure-dependent changes, IABP determined biomechanical changes related to variations in the VSM tone. The increased SS(R) and SS(O) were associated with the aortic VSM contraction pattern and biomechanical changes.

Cited by 28 publications

References 35 publications

Hemodynamic Analysis of Intracranial Aneurysms with Daughter Blebs

Hemodynamic Analysis of Intracranial Aneurysms with Daughter Blebs

Influence of Hemodynamic Factors on Rupture of Intracranial Aneurysms: Patient-Specific 3D Mirror Aneurysms Model Computational Fluid Dynamics Simulation

Cardiac resynchronization results in aortic blood flow-associated changes in the arterial load components: Basal biomechanical conditions determine the load changes

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