Increased risk for invasive pneumococcal diseases in children with acute lymphoblastic leukaemia

Meisel, Roland; Toschke, André Michael; Heiligensetzer, Cora; Dilloo, Dagmar; Laws, Hans‐Jürgen; Kries, R. von

doi:10.1111/j.1365-2141.2007.06601.x

Cited by 49 publications

(52 citation statements)

References 10 publications

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“…The risk of invasive pneumococcal disease (IPD) in children with ALL is reported to be high, with an incidence 10-fold, and up to 50-fold, than seen in healthy children 3. It has been estimated that this equates to an absolute risk of one case of IPD for every 357 cases of ALL 3.…”

Section: Introductionmentioning

confidence: 99%

Serotype-specific pneumococcal antibody concentrations in children treated for acute leukaemia: Table 1

et al. 2010

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Children treated for acute leukaemia are at increased risk of infection with Streptococcus pneumoniae. The basis for this may include low levels of pneumococcal antibody but this has not been well studied. The authors measured serotype-specific pneumococcal IgG antibody concentrations in children treated for acute lymphoblastic leukaemia (ALL) and acute myeloid leukaemia (AML) ≥6 months after completion of standard-dose chemotherapy. Pneumococcal serotype-specific IgG antibody concentrations were low. None of the subjects had protective concentrations against all the heptavalent-pneumococcal conjugate vaccine serotypes. There was no significant difference in antibody concentrations between subjects with ALL and AML (p≥0.05). Children treated for ALL and AML generally have non-protective antibody concentrations against S pneumoniae. There is significant morbidity associated with pneumococcal disease in this patient group and strategies for vaccination are required.

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Section: Introductionmentioning

confidence: 99%

Serotype-specific pneumococcal antibody concentrations in children treated for acute leukaemia: Table 1

et al. 2010

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“…The risk of IPD in children with acute lymphoblastic leukaemia is suggested to be ten to 50-fold that of healthy children [9]. Children with brain tumours are not usually perceived to be at higher risk of IPD but our patient was immunosuppressed as a result of chemotherapy.…”

Section: Discussionmentioning

confidence: 93%

Invasive pneumococcal disease following treatment for choroid plexus carcinoma

Jørgensen

Bate

Gatscher

et al. 2010

Support Care Cancer

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“…Recently, Meisel et al reported that the adjusted risk ratio (RR) of IPD was approximately 6 times higher (52.1) in patients with hematologic cancer than in those with nonhematologic malignancies, although this second group was at an increased risk of this disease (8.9) compared with healthy subjects. 5 Influenza vaccination in the current season was received significantly more often by pneumococcal carriers than by non-carriers. We do not have a clear explanation for this finding.…”

Section: Discussionmentioning

confidence: 99%

“…[1][2][3][4] Combining data from a nationwide surveillance for IPD and the German childhood cancer registry, Meisel et al showed that children with acute lymphoblastic leukemia (ALL) had a more than 10-fold higher risk for IPD compared with the general pediatric population. 5 Hjuler et al studied the risk for IPD in children 0-17 y old with underlying chronic disease and found that children with cancer had an adjusted relative risk of 19.0 compared with children who did not have cancer. 6 These findings explain why children with cancer worldwide are included in the list of subjects for whom the prevention of pneumococcal infections via vaccine administration is strongly recommended, 7 although their immune response can be suboptimal at least in some patients.…”

Section: Introductionmentioning

confidence: 99%

Streptococcus pneumoniaepharyngeal colonization in school-age children and adolescents with cancer

Principi

Preti

Gaspari

et al. 2015

Human Vaccines & Immunotherapeutics

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Patients with cancer, particularly those with hematologic malignancies, are at an increased risk of invasive pneumococcal disease (IPD) and they are included in the list of subjects for whom pneumococcal vaccination is recommended. The main aim of this study was to evaluate Streptococcus pneumoniae colonization in school-aged children and adolescents with cancer to determine the potential protective efficacy of 13-valent pneumococcal conjugate vaccine (PCV13). An oropharyngeal swab was obtained from 277 patients (age range 6-17 years) with cancer during routine clinical visits and analyzed for S. pneumoniae using real-time polymerase chain reaction. S. pneumoniae was identified in 52 patients (18.8%), including 47/235 (20.0%) with hematologic malignancies and 5/42 (11.9%) with solid tumors. Colonization declined significantly with an increase in age (odds ratio [OR] 0.34, 95% confidence interval [CI] 0.16-0.71, and OR 0.30, 95% CI 0.11-0.82 in children aged 10-14 and 15 years, respectively, as compared to those <10 years). Carriage was more common among patients with leukemia or lymphoma than in children with solid tumors. Co-trimoxazole prophylaxis was significantly associated with reduced pneumococcal carriage (OR 0.41, 95% CI 0.19-0.89). A total of 15/58 (25.9%) and 26/216 (12.0%) children were colonized by PCV13 serotypes among cancer patients previously vaccinated and not vaccinated with 7-valent pneumococcal conjugate vaccine (PCV7), respectively. In conclusion, this study indicates that children and adolescents with cancer are frequently colonized by S. pneumoniae. Because most of the carried serotypes are included in PCV13, this vaccine is presently the best solution to reduce the risk of IPD in these patients.

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Increased risk for invasive pneumococcal diseases in children with acute lymphoblastic leukaemia

Cited by 49 publications

References 10 publications

Serotype-specific pneumococcal antibody concentrations in children treated for acute leukaemia: Table 1

Serotype-specific pneumococcal antibody concentrations in children treated for acute leukaemia: Table 1

Invasive pneumococcal disease following treatment for choroid plexus carcinoma

Streptococcus pneumoniaepharyngeal colonization in school-age children and adolescents with cancer

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