Increased risk of cerebral venous sinus thrombosis with third-generation oral contraceptives

Bruijn, Sftm de; Stam, Jan; Jp, Vandenbroucke

doi:10.1016/s0140-6736(05)79442-3

Cited by 85 publications

(38 citation statements)

References 1 publication

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Contact with the experts and manual review of references did not reveal any additional studies. Nine of the 26 studies were subsequently excluded for the following reasons: 8 did not meet inclusion criteria 27,28,33,34,36,40,42,44 and 1 contained duplicate data. 25 Seventeen studies were therefore included in our systematic review.…”

Section: Study Identification and Selectionmentioning

confidence: 99%

Thrombophilic abnormalities, oral contraceptives, and risk of cerebral vein thrombosis: a meta-analysis

Dentali

Crowther

Ageno

2006

Blood

240

142

View full text Add to dashboard Cite

Recent studies suggest that thrombophilic abnormalities and the use of oral contraceptives (OCs) are the leading causes of cerebral vein thrombosis (CVT). The purpose of this study was to assess the association between CVT and thrombophilic states, OCs, and their interaction. For data sources, we used the MEDLINE, EMBASE, and Cochrane Library databases (January 1994 to March 2005), reference lists of retrieved articles, and contact with content experts. We selected studies comparing the prevalence of OC use and the prevalence of prothrombitic abnormalities in patients with CVT compared with healthy controls. Two reviewers independently selected studies and extracted study characteristics, quality, and outcomes. Odds ratios (ORs) were calculated for each trial and pooled using the Mantel-Haenszel method. Seventeen studies were included. There was an increased risk of CVT in patients using OCs (OR 5.59; 95% confidence interval [CI] 3.95 to 7.91; P < .001), and in patients with factor V Leiden (OR 3.38; 95% CI 2.27 to 5.05; P < .001), with mutation G20 210A of prothrombin (OR 9.27; 95% CI 5.85 to 14.67; P < .001) and with hyperhomocysteinemia (OR 4.07; 95% CI 2.54 to 6.52; P < .001). We concluded that OC users, and patients with factor V Leiden, the prothrombin G20 120A mutation, and hyperhomocysteinemia are at a significantly increased risk of CVT. (Blood. 2006;

show abstract

Section: Study Identification and Selectionmentioning

confidence: 99%

Thrombophilic abnormalities, oral contraceptives, and risk of cerebral vein thrombosis: a meta-analysis

Dentali

Crowther

Ageno

2006

Blood

240

142

View full text Add to dashboard Cite

show abstract

“…20,22,36,41,50,58 It is well known that thirdgeneration contraceptives substantially increase the risk of CVST. 20 Likewise, the risk of CVST is increased during the last trimester of pregnancy and during the postdelivery period. 12 Elderly patients with CVST are also a distinct group.…”

mentioning

confidence: 99%

Cerebral venous sinus thrombosis: review of the demographics, pathophysiology, current diagnosis, and treatment

Filippidis¹,

Kapsalaki

Patramani

et al. 2009

FOC

121

160

View full text Add to dashboard Cite

Cerebral venous sinus thrombosis (CVST) is a rare clinicopathological entity. The incidence of CVST in children and neonates has been reported to be as high as 7 cases per million people, whereas in adults the incidence is 3–4 cases per million. The predisposing factors to this condition are mainly genetic and acquired prothrombotic states and infection. The clinical picture of CVST is nonspecific, highly variable, and can mimic several other clinical conditions. Diagnosis of CVST is established with the implementation of neuroimaging studies, especially MR imaging and venography. Identification and elimination of the underlying cause, anticoagulation, proper management of intracranial hypertension, and anticonvulsant prophylaxis constitute cornerstones of CVST treatment. Newer treatment strategies such as endovascular thrombolysis and decompressive craniectomy have been recently used in the treatment of patients with CVST with variable success rates. Further clinical research must be performed to delineate the exact role of these newer treatments in the management of severe cases of CVST. The recent advances in the diagnosis and treatment of patients with CVST have significantly lowered the associated mortality and morbidity and have improved the outcome of these patients.

show abstract

“…1970'lerin ortalarına dek kadın ve erkeklerde eşit oranlarda tespit edilmekteyken, yakın geçmişte özel-likle 3. kuşak doğum kontrol ilaçlarının kullanılması ile birlikte gebelik ve lohusalık dönemlerinin protrombotik etkileri nedeni ile doğurganlık çağındaki kadınlarda daha sık gözlenmeye başlanmıştır (8,9). Literatürün aksine olgularımızda kadın erkek oranı benzerdi.…”

Section: Discussionunclassified

Clinic and aetiology of cases with cerebral venous thrombosis; survey of 13 cases

Çoban¹,

Gökyiğit²

2012

Türk Beyin Damar Hast Derg

View full text Add to dashboard Cite

GİRİŞSerebral venöz tromboz (SVT) sık görülmey-en ancak ciddi sonuçlara neden olabilen bir hastalıktır. Tüm inme nedenlerinin yaklaşık % 0.5'ini oluşturmaktadır (1). Her yaşta görülebilirse de sıklıkla genç erişkin yaş grubunu etkilemektedir. Genç kadınlarda doğum kontrol haplarının kullanılması ve lohusalık dönemi nedeni ile 20-35 yaşları arasında sıklığı daha fazladır (2,3). En sık sü-perior sagittal sinüs, transvers ve sigmoid sinüsler, kavernöz sinüs ve sinüs rectus etkilenmektedir (4). Klinik başlıca 4 farklı tabloda incelenebilir; izole kafa içi basınç artış sendromu, fokal defisit ve/veya epileptik nöbetler, subakut ensefalopati tablosu, kavernöz sinüs trombozu tablosu (5,6). SVT'un sebebi sıklıkla multifaktoriyeldir, % 20-25 olguda risk faktörü tanımlanamamaktadır (7). SEREBRAL VENÖZ TROMBOZ CLINIC AND AETIOLOGY OF CASES WITH CEREBRAL VENOUS THROMBOSIS; SURVEY OF 13 CASES SUMMARYCerebral venous thrombosis (CVT) is seen in all ages. It is mostly presented as increased intracranial pressure. The most affected dural sinuse is superior sagittal sinuse. The aetiology is often identified. 13 CVT cases were examined in Neurology Clinic of Şişli Etfal Hospital between April and December 2010 about clinical presentations and aetiology. Cranial MRI venougraphy was performed for diagnosis, genetic and acquired prothrombotic conditions for aetiology. The gender of cases were similar. The symptoms of the patients were as follows; headache in 5 patients, diplopia in 4, weakness in 1, sensory disturbance in 3 and seizure in 1 patient. In their neurological examinations, 6th cranial nerve palsy was found in 4 patients, papil edema in 2 patients, hemiparesis in 2 and hemihypoestesia in 1 patient. They all had transvers sinus occlusion. The predisposan factors were; oral contraseptive usage, 20 week pregnancy, otitis media infection and nasal operation. Genetic prothrombotic conditions were positive lupus anticoagulant test and Factor 5 leiden heterozigot gene mutation. In conclusion; Many clinical presentations have been described in CVT patients; but the most seen clinical presentation is intracranial hypertension. Although the disease is rarely seen, the cases of unknown causes are still frequent.

show abstract

Increased risk of cerebral venous sinus thrombosis with third-generation oral contraceptives

Cited by 85 publications

References 1 publication

Thrombophilic abnormalities, oral contraceptives, and risk of cerebral vein thrombosis: a meta-analysis

Thrombophilic abnormalities, oral contraceptives, and risk of cerebral vein thrombosis: a meta-analysis

Cerebral venous sinus thrombosis: review of the demographics, pathophysiology, current diagnosis, and treatment

Clinic and aetiology of cases with cerebral venous thrombosis; survey of 13 cases

Contact Info

Product

Resources

About