Increased risk of depression and impairment in quality of life in patients with lamellar ichthyosis

Abstract

Lamellar ichthyosis (LI) is a genetic skin disorder characterized by dark brown scales, palmoplantar hyperkeratosis, pain, and itching. LI severity could have implications in psychological aspects, causing depression and impairment in the quality of life (QoL) of patients. In this study, we used the Congenital Ichthyosis Severity Index, the Depression Beck Inventory‐II (DBI‐II), and the Dermatologic Life Quality Index (DLQI) to assess severity, level of depression, and impairment in QoL in a group of patients with LI. We observed that the majority of the patients presented a high severity level concerning the presence of scales (57.7%), while for erythema and alopecia, the severity was less 80% of the analyzed patients presented depression, while only 20.8% of individuals of the control group presented it (P < .001, OR = 15.2). While for QoL, only 4.3% of the patients did not exhibit any impairment. Finally, the increase in the score obtained in DBI‐II was correlated with the DLQI score (rs = 0.663, P = .0014). Our results suggest that patients with LI have an increased risk of suffering depression and impairment in their QoL; thus, the management of their disease should be performed from a multidisciplinary perspective to improve the global aspects of their lives.

Alterations in mental health and quality of life in patients with skin disorders: a narrative review

“…Likewise, we recently conducted a casecontrol study with 26 patients with ARCI and 26 healthy volunteers. 37 We evaluated the severity of symptoms (CISI scale), the presence of depression (the Beck Depression Inventory), and the QoL (DLQI) impairment in those patients. We found that ARCI patients exhibited an increased risk of suffering from depression (80% of patients showed depression vs. 20% of control individuals) and impairment in their QoL.…”

“…Remarkably, both studies revealed a statistically significant correlation between QoL and mental health because patients that suffered a more considerable impact on their QoL presented with higher levels of anxiety and depression. 7,37 However, the depression and DLQI scores will also depend on the country's development, geographic region, educational status, socioeconomic profile, religion, age, and sex.…”

“…Adults revealed a higher frequency of depression (34.4%) than anxiety (27.3%), while in children, the prevalence was the reverse, with less depression (30.2%) than anxiety (37.7%). Likewise, we recently conducted a case‐control study with 26 patients with ARCI and 26 healthy volunteers 37 . We evaluated the severity of symptoms (CISI scale), the presence of depression (the Beck Depression Inventory), and the QoL (DLQI) impairment in those patients.…”

Mood symptoms, neurodevelopmental traits, and their contributory factors in X-linked ichthyosis, ichthyosis vulgaris and psoriasis

“…23,24 The correlates of rarer skin conditions such as the inherited ichthyoses, which are characterized by abnormal keratinization, 25 are comparatively less well-defined, although there is recent evidence that across the ichthyoses, rates of psychological distress are raised while QoL is diminished. 26,27 Qualitative data have suggested that QoL impairment in inherited ichthyoses may be due to a combination of factors, including physical health, daily life issues, and relationships with oneself and others. 28 As the ichthyoses have differences in aetiology, severity and epidemiology, there is a need to study each separately.…”

“…Psoriasis has been associated with a substantially increased risk of depression or anxiety disorders 21,22 and neurodevelopmental conditions, notably autism spectrum disorder 23,24 . The correlates of rarer skin conditions such as the inherited ichthyoses, which are characterized by abnormal keratinization, 25 are comparatively less well‐defined, although there is recent evidence that across the ichthyoses, rates of psychological distress are raised while QoL is diminished 26,27 . Qualitative data have suggested that QoL impairment in inherited ichthyoses may be due to a combination of factors, including physical health, daily life issues, and relationships with oneself and others 28 .…”