Increased risk of developing ankylosing spondylitis among first-born children

Baudoin, P.; Horst‐Bruinsma, Irene E. van der; Dekker-Saeys, A. J.; Weinreich, S.; Bezemer, P.D.; Dijkmans, B. A. C.

doi:10.1002/1529-0131(200012)43:12<2818::aid-anr23>3.0.co;2-f

Cited by 20 publications

(7 citation statements)

References 21 publications

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“…As expected, the presence of HLA-B27 also correlated with the development of ReA. Baudoin et al [76] reported that AS was more likely to occur in first-born children. In addition, the mean age at first delivery among mothers of patients with AS was lower than the overall population observed (Dutch).…”

Section: Environmental Factorssupporting

confidence: 61%

Predisposing factors in the Spondyloarthropathies: New insights into the role of HLA-B27

Colbert

Prahalad

2001

Curr Rheumatol Rep

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Spondyloarthropathies represent complex genetic diseases whose development is influenced by environmental factors. Estimates suggest that three to nine loci may be responsible for the majority of the genetic susceptibility to ankylosing spondylitis. The only susceptibility locus identified to date in multiple populations is HLA-B, where several HLA-B27 alleles (subtypes) are strongly associated with disease. Recent evidence implicates cytochrome P450 2D6 as a second locus, although its influence on overall risk appears small. Despite considerable efforts to define how HLA-B27 contributes to disease, its role remains enigmatic. Increasing evidence suggests it has effects that are unrelated to its physiologic function. The basis for this is unknown but may be a consequence of the unusual tendency of this allele to misfold.

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Section: Environmental Factorssupporting

confidence: 61%

Predisposing factors in the Spondyloarthropathies: New insights into the role of HLA-B27

Colbert

Prahalad

2001

Curr Rheumatol Rep

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“…It is conceivable that reproductive factors, such as maternal age or birth order, could influence susceptibility to JIA and other autoimmune diseases. An association between ankylosing spondylitis (AS) and low birth order has been reported (1), although other investigators have been unable to confirm this association (2, 3). To our knowledge, associations between JIA and birth order have not been reported.…”

Section: Birth Orders Of Cases and Controls*mentioning

confidence: 99%

Lack of association between birth order and juvenile idiopathic arthritis

Prahalad¹,

Fraser²,

O’Brien³

et al. 2003

Arthritis & Rheumatism

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Lack of association between birth order and juvenile idiopathic arthritisAlthough the cause of juvenile idiopathic arthritis (JIA) is still not well elucidated, evidence suggests that a complex interplay of genetic and environmental factors underlies its pathogenesis. JIA includes phenotypically and genetically distinct subtypes, with different ages at onset. It has been hypothesized that intrauterine or early childhood environmental factors might influence susceptibility to autoimmune diseases. It is conceivable that reproductive factors, such as maternal age or birth order, could influence susceptibility to JIA and other autoimmune diseases. An association between ankylosing spondylitis (AS) and low birth order has been reported (1), although other investigators have been unable to confirm this association (2,3). To our knowledge, associations between JIA and birth order have not been reported. In this analysis, we address the question of a possible association between birth order and JIA.Information on JIA patients seen at the pediatric rheumatology clinics at the University of Utah was entered into a clinical database; clinical and demographic data were collected by chart review and questionnaire. Most of the patients had been cared for by one of the authors (JFB). Charts were reviewed by a second pediatric rheumatologist (SP) and the diagnosis confirmed. Patients who did not meet the International League of Associations for Rheumatology criteria for JIA (4) were not included. Subjects were linked with records in the Utah Population Database (UPDB), a computerized database of more than 7 million records that includes genealogies, birth certificates, death certificates, and other records. A program called Integrity was used to perform probabilistic linking of records in these 2 databases. Weights were calculated to measure the contribution of each field to the probability of matching 2 records. A link was accepted if the composite weight was above a specified threshold. For each linked case, ϳ10 controls matched by sex and birth year were selected. Information on birth order, sibship size, and maternal age at delivery was obtained primarily from 1.7 million birth certificates in the UPDB. The cases and matched controls were born between 1976 and 1999. Chi-square tests were used to compare the birth order distributions among cases and controls and t-tests were used to compare maternal age at delivery. The study was approved by the Institutional Review Board and the Utah Resource of Genetic and Epidemiology Research, which administers access to the UPDB.A total of 333 cases and 3,295 controls were analyzed. There were 206 female and 127 male patients with JIA.

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“…As younger AS females are more likely to carry a greater genetic load than males, it is postulated that they are more likely to transmit their disease, thus explaining the clinical observation. An increased risk of developing AS in the first born children has also been reported [11], but this finding has not been replicated in subsequent cohorts [12].…”

Section: Mode Of Inheritance In Asmentioning

confidence: 99%

Genetics of ankylosing spondylitis: An update

Rahman¹

2007

Curr Rheumatol Rep

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Substantive evidence exists that genetic factors play a pivotal role in susceptibility to ankylosing spondylitis (AS). HLA-B27 remains the most convincing and universal association of a genetic factor with AS. Over the last decade there has been immense interest in elucidating genetic variants outside the major histocompatibility complex region. Due to larger AS datasets along with recent advancements in the characterization of genetic markers and large-scale genotyping platforms, replicated non-major histocompatibility candidates have now emerged. This article reviews the current evidence regarding the genetics of AS, with an emphasis on the recent major advances, and it discusses the challenges and limitations in interpreting these studies.

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Increased risk of developing ankylosing spondylitis among first-born children

Cited by 20 publications

References 21 publications

Predisposing factors in the Spondyloarthropathies: New insights into the role of HLA-B27

Predisposing factors in the Spondyloarthropathies: New insights into the role of HLA-B27

Lack of association between birth order and juvenile idiopathic arthritis

Genetics of ankylosing spondylitis: An update

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