Increased risk of fundic gland polyps during long‐term proton pump inhibitor therapy

Jalving, Mathilde; Koornstra, Jan J.; Wesseling, Jelle; Boezen, H.M.; Jong, de Steven; Kleibeuker, Jan H.

doi:10.1111/j.1365-2036.2006.03127.x

Cited by 233 publications

(261 citation statements)

References 31 publications

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“…In contrast to reports by Carmack et al (10) and Stolte et al (30), in which fundic gland polyps were reported as the most common gastric polyps, with a relative frequency of 77% and 47%, respectively, in our study, fundic gland polyps accounted for less than 6.1% of all polyps. Fundic gland polyps have almost no malignant potential when they are associated with the use of PPIs (11,31,32) or when they occur sporadically (33). Similarly, we found neither dysplasia nor malignancy in the fundic gland polyps in our study.…”

Section: Discussionmentioning

confidence: 34%

“…In countries in which Helicobacter pylori infections are commonly seen, hyperplastic and adenomatous polyps are found to be more frequent than fundic gland polyps (8,9). In western countries, where H. pylori infections are less common and proton pump inhibitor (PPI) drug use is more common, fundic gland polyps are seen more frequently (10,11). As modern examinations of the digestive system have increased in number, gastric polyps are now detected more frequently (6).…”

Section: Introductionmentioning

confidence: 99%

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Evaluation of gastric polyps detected by endoscopy: A single-center study of a four-year experience in Turkey

Atalay

Solakoğlu²,

Sarı³

et al. 2020

Turk J Gastroenterol

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Background/Aims: The aim of this study was to evaluate the gastric polyps detected by endoscopy in our institution with respect to their frequency, size, anatomic location, presence of dysplasia, and histopathologic features. Materials and Methods: Records of a total of 14,240 patients who underwent endoscopy between January 2008 and January 2012 were reviewed retrospectively. Of the 14,240 patients, 174 determined to have at least 1 histopathologically proven polyp were included in the study. Results: Three hundred eleven gastric polyps were found in 174/14,240 (1.2%) patients (1.79 polyps per patient). Gastric polyps were found most commonly in the antrum (41.5%). Of all gastric polyps, 189 (60.8%) were less than 1 cm. Histopathologically, the most common polyp type was hyperplastic (n: 261, 83.9%), followed by adenomatous (n: 23, 7.4%). Eight (34.8%) of the adenomatous polyps showed dysplasia, and in 4 (17.4%) of these cases, the dysplasia was high-grade. Nineteen (6.1%) of all gastric polyps were identified to be fundic gland polyps. Conclusion: According to this study from Turkey, the majority of polyps detected by endoscopy was solitary, smaller than 1 cm, and found in the antrum; furthermore, the most common type was a hyperplastic polyp.

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Section: Discussionmentioning

confidence: 34%

Section: Introductionmentioning

confidence: 99%

Evaluation of gastric polyps detected by endoscopy: A single-center study of a four-year experience in Turkey

Atalay

Solakoğlu²,

Sarı³

et al. 2020

Turk J Gastroenterol

View full text Add to dashboard Cite

show abstract

“…About 70% of gastric polyps were hyperplastic, while 12% were noninvasive intramucosal neoplasias (adenomas), and 16% were fundic gland polyps. In Western countries, the most commonly encountered polyps are fundic gland polyps because H. pylori infection is less frequent and proton pump inhibitor use is common (10). The frequency and most common type of gastric polyp vary widely depending upon the population studied.…”

Section: Discussionmentioning

confidence: 99%

Orta Anadolu bölgesinde gastrik polip prevalansı ve histopatolojik durumları

Karaman¹,

Denız²,

Karaman³

et al. 2015

Endoskopi Gastrointestinal

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Girifl ve Amaç: : Gastrik polipler baz›lar›nda malign potansiyel oldu¤u için önem arzederler. Baz› polipler ç›kar›lmaz ise mide kanseri geliflebilir. Mide polibi prevalans› ve histopatolojik durumlar› toplumlara göre de¤iflim gösterir. Bu çal›flma Orta Anadolu Bölgesi'nde mide polibi prevalans› ve histopatolojik durumlar› de¤erlendirilmek için planland›. Gereç ve Yöntem: Erciyes Üniversitesi T›p Fakültesi Gastroenteroloji klini¤inde A¤ustos 2007-2009 y›llar› aras›nda üst endoskopi yap›lan hastalar›n t›bbi kay›tlar› taranarak yap›ld›. Bulgular: Üst endoskopi yap›lan 5582 erkek, 6016 kad›n olmak üzere toplam 11598 hasta incelendi. 69 hastada (25 erkek, 44 kad›n) mide polibi görülerek biyopsi al›nd›¤› tespit edildi. Buna gore gastrik polip prevalans› yaklafl›k %0.59 olarak tespit edildi. ‹statistiksel analizler polip yerleflim yeri ile histopatolojik durum aras›nda korelasyon olmad›¤›n› gösterdi. Sonuç: Bölgemizde malign ve premalign polip oran› tüm mide poliplerinin içinde oldukça yüksektir. Bu tür poliplerin yüksek s›kl¤›n›n sebebini araflt›ran H. pylori ve daha fazla verinin de¤erlendirildi¤i genifl prospektif çal›flmalara ihtiyaç vard›r.

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“…A PPI-kezelés ismerten fokozza a szérumgasztrinszin-tet, ezért elképzelhető, hogy a gasztrin-koncentráció emelkedése a gyomornyálkahártyára tropikus hatást fejt ki, és az FMP ennek a tartós hatásnak a következménye. Az irodalomban a tartós PPI-kezelés és a fundusmirigyhyperplasia oki kapcsolatával kapcsolatban pró [10,11,12] és kontra [13,14] véleményeket is olvashatunk. Saját megfi gyelésünk szerint a gyógyszer szedése és az FMP epidemiológiailag összefügghetnek.…”

Section: Megbeszélésunclassified

Prevalence of gastric polypoid lesions in a single endoscopic centre

et al. 2013

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Bevezetés: A gyomor polypoid elváltozásainak hazai előfordulási gyakorisága nem ismert. Cél: A szerzők célul tűzték ki a Semmelweis Egyetem, II. Belgyógyászati Klinika endoszkópos centrumában a gyomorpolip gyakoriságának és az azt befolyásoló kóroki tényezőknek a vizsgálatát. Módszerek: 16 hónap alatt végzett felső panendoszkópiák egységes szövettani és klinikai adatait értékelték. Eredmények: 4174 gasztroszkópia során 193 (4,62%) polipot észlel-tek. A betegek átlagéletkora a diagnóziskor 65,9±12,7 év volt. A polipok 33,67%-a hyperplasticus, 31,09%-a fundusmirigypolip, 2,07%-a malignus volt. A fundusmirigypolipos betegek körében gyakoribb volt a protonpumpagátló-használat (p = 0,007), míg a hyperplasticus polipos csoportban gyakrabban találtunk idült gastritist (p = 0,032). A Helicobacter pylori-fertőzöttség egyik szövettanú polip jelenlétével sem függött össze. Következtetés: Hazai betegek körében gyakoribb a gyomorpolip, mint az az irodalmi adatok alapján várható lenne. A fundusmirigypolipok gyakoribbak tartós protonpumpagátló-használó betegekben, a hyperplasticus polipok előfordulása pedig az idült gastritisek gyakoriságával mutat összefüggést. Orv. Hetil., 2013, 154, 770-774. Kulcsszavak: gyomorpolip, incidencia, etiológia, protonpumpagátló Prevalence of gastric polypoid lesions in a single endoscopic centreBackground: The prevalence of gastric polyps is unknown in Hungary. Aim: The aim of the authors was to assess the prevalence of polypoid lesions of the stomach in the endoscopic centre of the 2nd Department of Medicine, Semmelweis University. Methods: Results of upper gastrointestinal endoscopies carried out between March 2010 and June 2011 were analysed. Results: 193 cases with polyps were diagnosed in 4174 endoscopies (4.62%). Hyperplastic polyps, fundic gland polyps and malignant lesion were detected in 33.67%, 31.09% and 2.07% of the cases, respectively. Proton pump inhibitor use was more frequent among patients diagnosed with fundus gland polyps (p = 0.007), while hyperplastic polyps were diagnosed more frequently in patients with chronic gastritis (p = 0.032). Conclusions: The frequency of gastric polyps was higher than expected from data published in the literature. Longterm proton pump-inhibitor use and chronic gastritis were associated with fundus gland and hyperplastic polyps, respectively. Orv. Hetil., 2013, 154, 770-774.

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Increased risk of fundic gland polyps during long‐term proton pump inhibitor therapy

Abstract: SUMMARY BackgroundIt is controversial whether proton pump inhibitor use leads to fundic gland polyp development.

Cited by 233 publications

References 31 publications

Evaluation of gastric polyps detected by endoscopy: A single-center study of a four-year experience in Turkey

Evaluation of gastric polyps detected by endoscopy: A single-center study of a four-year experience in Turkey

Orta Anadolu bölgesinde gastrik polip prevalansı ve histopatolojik durumları

Prevalence of gastric polypoid lesions in a single endoscopic centre

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