Increased risk of hospital admission for mood disorders following admission for epilepsy

Kim, Anna M.; Rossi, Kyle C.; Yoo, Ji Yeoun; Hung, Kenneth W.; Dhamoon, Mandip S.

doi:10.1212/01.wnl.0000542492.00605.9d

Cited by 14 publications

(6 citation statements)

References 43 publications

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“…Medical comorbidities such as hypertension, diabetes, renal disease, coagulopathies, autoimmune disease, sepsis, and psychiatric disorders were identified using validated ICD‐9‐CM codes 13 from previously published studies and/or Clinical Classification Software codes, which consist of grouped ICD‐9‐CM codes developed as a publicly available software tool via HCUP 24–29 . Codes for nausea and vomiting and rheumatoid arthritis were obtained from manual review of ICD‐9 codes.…”

Section: Methodsmentioning

confidence: 99%

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Pregnancy‐related complications and risk of postpartum readmission for seizures and epilepsy: A national study

et al. 2020

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Objective: Peripartum seizures remain a leading cause of maternal morbidity and mortality worldwide. Therefore, recognition of high-risk individuals is essential. We aimed to determine the rate and identify risk factors for postpartum seizure/epilepsy readmissions. Methods: In this retrospective cohort study, the Nationwide Readmissions Database was used to identify index admissions for delivery and readmissions for seizures in the year 2013, defined by International Classification of Disease, Ninth Revision, Clinical Modification codes for epilepsy, convulsions, and eclampsia in the primary diagnostic position. Logistic regression analysis was used to examine 30-day readmission for seizures as well as associations between demographic, medical, psychiatric, and pregnancy-related factors. Results: There were 1 633 714 index admissions for delivery, with a 30-day readmission rate for seizures/epilepsy of 19.69 per 100 000 index admissions. The mean age of index participants was 28.6 years (SD = 5.8). Postpartum 30-day readmissions for eclampsia represented 80% of seizure/epilepsy readmissions. Higher income was associated with lower odds of seizure/epilepsy readmission (odds ratio [OR] = 0.50, 95% confidence interval [CI] = 0.34-0.72, P = .03) for the highest income group.

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Section: Methodsmentioning

confidence: 99%

“…grouped ICD-9-CM codes developed as a publicly available software tool via HCUP. [24][25][26][27][28][29] Codes for nausea and vomiting and rheumatoid arthritis were obtained from manual review of ICD-9 codes. Additional covariates such as age and income quartile were obtained from the NRD.…”

Section: Key Pointsmentioning

confidence: 99%

Pregnancy‐related complications and risk of postpartum readmission for seizures and epilepsy: A national study

et al. 2020

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“…Dr Mackenzie C. Cervenka started the symposium by addressing hospital admissions of patients with intellectual developmental disabilities (IDD) to the Epilepsy Monitoring Unit (EMU). 22 The unique challenges of individuals admitted to the unit, as well as their caregivers and treating team were discussed. The patient Adam offered key takeaways that brought the message home from the lens of a patient.…”

Section: Best Practices In Clinical Epilepsy Symposiummentioning

confidence: 99%

Highlights From AES2020, a Virtual American Epilepsy Society Experience

et al. 2021

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Due to COVID-19 a live, in-person meeting was not possible for the American Epilepsy Society in 2020. An alternative, virtual event, the AES2020, was held instead. AES2020 was a great success with 4679 attendees from 70 countries. The educational content was outstanding and spanned the causes, treatments, and outcomes from epileptic encephalopathy to the iatrogenicity of epilepsy interventions to neurocognitive disabilities to the approach to neocortical epilepsies. New gene therapy approaches such as antisense oligonucleotide treatment for Dravet syndrome were introduced and neuromodulation devices were discussed. There were many other topics discussed in special interest groups and investigators’ workshops. A highlight was having a Nobel prize winner speak about memory processing. Human intracranial electrophysiology contributes insights into memory processing and complements animal work. In a special COVID symposium, the impact of COVID on patients with epilepsy was reviewed. Telehealth has been expanded rapidly and may be well suited for some parts of epilepsy care. In summary, the epilepsy community was alive and engaged despite being limited to a virtual platform.

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“…In the general population, the average unplanned (or acute) readmission rate within 30 days of epilepsy- or seizure-related hospitalisations is 10%, with epilepsy or seizure being the most common indication [ 20 , 21 ]. Other common reasons for readmission within a year include psychiatric disorders [ 22 , 23 ] and suicide attempts [ 24 ]. Few studies have reported readmission after epilepsy hospitalisation in people with intellectual disability, with one observing an increased risk of readmission in children with intellectual disability compared to children without [ 20 ].…”

Section: Introductionmentioning

confidence: 99%

Readmission and emergency department presentation after hospitalisation for epilepsy in people with intellectual disability: A data linkage study

et al. 2022

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Background Despite the high prevalence of epilepsy and multiple barriers to care in people with intellectual disability, the risk of returning to hospital after an admission for epilepsy is largely unknown. In this study, we sought to quantify and compare readmission and emergency department (ED) presentations after hospitalisation for epilepsy in people with and without intellectual disability. Methods and findings Using linked administrative datasets, we conducted a retrospective cohort study of people aged 5–64 years with an acute hospitalisation for epilepsy from 2005–2014 in New South Wales, Australia. Acute readmission and ED presentation rates within 30, 90, and 365 days of the index hospitalisation were estimated and compared between people with and without intellectual disability using modified Poisson regression. Of 13537 individuals with an index hospitalisation, 712 children and 1862 adults had intellectual disability. Readmission and ED presentation after the index hospitalisation were common in people with intellectual disability. Within 30 days, 11% of children and 15.6% of adults had an all-cause readmission and 18% of children and 23.5% of adults had an ED presentation. Over 60% of both children and adults presented to an ED within a year. Neurological, respiratory, and infectious conditions were overrepresented reasons for readmission in people with intellectual disability. Age-adjusted relative risks (RRs) within each period showed a higher risk of readmission and ED presentation in children and adults with intellectual disability than without. Most RRs remained statistically significant after controlling for covariates. The largest adjusted RRs were observed for readmission for epilepsy (RR 1.70, 95% CI: 1.42 to 2.04) and non-epilepsy related conditions (RR 1.73, 95%: CI 1.43 to 2.10) in children. Study limitations include lack of clinical data. Conclusions Increased risk of returning to acute care after epilepsy hospitalisation suggests there is a need to improve epilepsy care for people with intellectual disability. We recommend research into strategies to improve management of both seizures and comorbidity.

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Increased risk of hospital admission for mood disorders following admission for epilepsy

Abstract: Admission for epilepsy was independently associated with subsequent hospital readmission for mood disorders. The magnitude of elevated risk in this population suggests that patients admitted with epilepsy may warrant targeted psychiatric screening during their hospital admission.

Cited by 14 publications

References 43 publications

Pregnancy‐related complications and risk of postpartum readmission for seizures and epilepsy: A national study

Pregnancy‐related complications and risk of postpartum readmission for seizures and epilepsy: A national study

Highlights From AES2020, a Virtual American Epilepsy Society Experience

Readmission and emergency department presentation after hospitalisation for epilepsy in people with intellectual disability: A data linkage study

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