Increased risk of hyperlipidemia in patients with bipolar disorder: a population-based study

Hsu, Jer-Hwa; Chien, I‐Chia; Lin, Ching-Heng

doi:10.1016/j.genhosppsych.2015.04.003

Cited by 38 publications

(24 citation statements)

References 39 publications

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“…Hsu et al. found an obesity prevalence of 55% among patients with BD [5]. In a study by McElroy et al.…”

Section: Discussionmentioning

confidence: 96%

“…Obesity has been demonstrated to be more common in these patients compared to the healthy population; this may result from the fact that these two disorders, BD and obesity, share a similar pathophysiology regarding inflammation [20]. Hsu et al found an obesity prevalence of 55% among patients with BD [5]. In a study by McElroy et al of 644 outpatients with BD diagnoses, 26% were found to be obese [21].…”

Section: Discussionmentioning

confidence: 99%

“…However, the factors suspected include lifestyle, inappropriate eating habits, sleep disturbances, and physical inactivity. Genetic damage, inflammatory responses, increased stress, and treatment-related side effects may induce the progress of metabolic processes in patients with BD [5].…”

Section: Introductionmentioning

confidence: 99%

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Metabolic syndrome and vaspin in patients with bipolar disorder

Ertekin

Şahin

Çalışkan

et al. 2018

The Kaohsiung J of Med Scie

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Metabolic disorders and abnormal levels of circulating adipokines have been reported in patients with bipolar disorder (BD). The aim of this study was to investigate the differences in the correlations of vaspin plasma levels and metabolic parameters between two groups: patients with BD and mentally healthy persons. We measured plasma levels of vaspin, metabolic parameters, and metabolic syndrome (MS) in 101 patients with BD and 90 healthy control (HC) subjects. Patients with BD were evaluated with the Young Mania Rating Scale (YMRS) to assess manic symptoms and the Hamilton Depression Scale (HDS) to assess depressive symptoms. The Global Assessment of Functioning (GAF) was used to evaluate the general functions of the patients. Body mass index (BMI), weight, waist circumference (WC), fasting glucose, and triglyceride levels of the study group were statistically higher than those of the healthy controls (p = 0.001, p < 0.001, p < 0.001, p = 0.027, and p = 0.001 respectively). Plasma levels of vaspin were 0.978 ng/ml in patients with BD and 0.292 in the HC group (p < 0.001). Our study revealed associations between metabolic parameters/metabolic syndrome and vaspin plasma concentrations in patients with BD. Vaspin can play a specific role in the pathogenesis of metabolic disorders in these subjects and can be a specific indicator substance in BD.

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“…Hsu et al. found an obesity prevalence of 55% among patients with BD [5]. In a study by McElroy et al.…”

Section: Discussionmentioning

confidence: 96%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Metabolic syndrome and vaspin in patients with bipolar disorder

Ertekin

Şahin

Çalışkan

et al. 2018

The Kaohsiung J of Med Scie

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“…Therefore, these are the first results with clear functional relevance connected to BD, which indicates that the lipid abnormality may be associated with the pathophysiology of BD. This view is supported by traditional epidemiologic surveys in which the prevalence of hyperlipidemia or metabolic syndrome in BD was found to be more common than that in the general population . Furthermore, to avoid the medication effect (second‐generation antipsychotics have a high risk for dyslipidemia or type II diabetes), studies with small sample sizes have shown increased prevalences of metabolic syndrome in first‐degree relatives of psychosis subjects (including those with BD) and in drug‐naïve patients with BD .…”

Section: Summary Of Gwas Findingsmentioning

confidence: 94%

Genome‐wide association studies of bipolar disorder: A systematic review of recent findings and their clinical implications

Ikeda

Takeo

Kondo

et al. 2017

Psychiatry Clin Neurosci

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Recent advances in molecular genetics have enabled assessments of the associations among genetic variants (e.g., single-nucleotide polymorphisms) and susceptibility for complex diseases, including psychiatric disorders. Specifically, genome-wide association studies (GWAS), meta-analyses of the GWAS summary statistics, and mega-analyses (which use raw data, not summary statistics) of GWAS have provided revolutionary results and have identified numerous susceptibility genes or single-nucleotide polymorphisms. By using several tens of thousands of subjects, >40 genes have been identified as being associated with susceptibility for bipolar disorder so far. The purpose of this systematic review was to summarize the recent findings of bipolar disorder GWAS and discuss their clinical implications.

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“…Patients who had at least two service claims during 2005 for either outpatient or inpatient care, with a primary or secondary diagnosis of an anxiety disorder, were identified. [12,13].…”

Section: Definition Of Anxiety Disordersmentioning

confidence: 99%

Increased risk of hyperlipidemia in patients with anxiety disorders: A population-based study

Chien

Lin

2020

Preprint

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Objective This study examined the prevalence and incidence of hyperlipidemia among patients with anxiety disorders in Taiwan. Methods We used a large dataset containing random samples, and more than 766,000 subjects who were aged 18 years or older in 2005 were identified. Subjects who had more than one primary or secondary diagnosis of anxiety disorders were identified. Individuals who had a primary or secondary diagnosis of hyperlipidemia or medication treatment for hyperlipidemia were also identified. The prevalence rate of hyperlipidemia in patients with anxiety disorders with that of the general population in 2005 was compared. We then followed this cohort to monitor incident cases of hyperlipidemia in anxiety patients, and assessed whether a difference existed from the general population during the period 2006–2010. Results A higher prevalence rate of hyperlipidemia in patients with anxiety disorders was observed as compared with the general population (21.3% vs. 7.6%, odds ratio 2.14; 95% confidence interval, 2.07–2.22) in 2005. Additionally, a higher average annual incidence rate of hyperlipidemia in patients with anxiety disorders was also found as compared with the general population (5.49% vs. 2.50%, risk ratio 1.64; 95% confidence interval, 1.58–1.70) from 2006 to 2010. Conclusions Patients with anxiety disorders had higher prevalence and incidence rates of hyperlipidemia than the general population. Risk factors that were found to be associated with the higher incidence rate of hyperlipidemia among anxiety patients included a greater age, the female gender, and the presence of diabetes and hypertension.

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Increased risk of hyperlipidemia in patients with bipolar disorder: a population-based study

Cited by 38 publications

References 39 publications

Metabolic syndrome and vaspin in patients with bipolar disorder

Metabolic syndrome and vaspin in patients with bipolar disorder

Genome‐wide association studies of bipolar disorder: A systematic review of recent findings and their clinical implications

Increased risk of hyperlipidemia in patients with anxiety disorders: A population-based study

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