Increased risk of idiopathic nephrotic syndrome in children with atopic dermatitis

Wei, Chang; Tsai, Jeng Dau; Lin, Cheng Li; Shen, Te Chun; Li, Tsai‐Chung; Chung, Chi Jung

doi:10.1007/s00467-014-2835-2

Cited by 31 publications

(33 citation statements)

References 30 publications

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“…Importantly, MCD can be successfully treated by immunosuppressive drugs, suggesting that immunologic responses are critical (23,37,38). Numerous reports associate MCD with atopy, as evidenced by elevated expression of IgE and increased prevalence of atopy in patients with MCD compared with control subjects (39)(40)(41)(42). In line with these studies, T cells from patients with MCD produce elevated amounts of IL-13 compared with those from control subjects (43)(44)(45), which may contribute to the observed IgE in these patients (46,47).…”

Section: Discussionmentioning

confidence: 99%

Synaptopodin is upregulated by IL-13 in eosinophilic esophagitis and regulates esophageal epithelial cell motility and barrier integrity

Rochman¹,

Travers²,

Abonia³

et al. 2017

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Section: Discussionmentioning

confidence: 99%

Synaptopodin is upregulated by IL-13 in eosinophilic esophagitis and regulates esophageal epithelial cell motility and barrier integrity

Rochman¹,

Travers²,

Abonia³

et al. 2017

JCI Insight

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“…18 The high reliability of the diagnostic data from the NHIRD has been evaluated in previous studies. 19–22 This study utilized a data file derived from the NHIRD, containing information from half of all insured children in Taiwan, chosen at random.…”

Section: Methodsmentioning

confidence: 99%

Atopic Dermatitis and Association of Risk for Henoch–Schönlein Purpura (IgA Vasculitis) and Renal Involvement Among Children

et al. 2016

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Elevation of Th2 cytokine-driven inflammatory mediators has been reported in acute stage of Henoch–Schönlein purpura (HSP). However, the temporal interaction between Th2-mediated allergic diseases and HSP with renal involvement remains unknown. Herein, we conducted a population-based cohort analysis to investigate the risk of HSP and renal involvement in children with atopic dermatitis (AD) as 1 of the first steps in the atopic march.From 2000 to 2007, 95,208 children with newly diagnosed AD and 190,416 randomly selected non-AD controls were included in the study. By the end of 2008, incidences of HSP in both cohorts and the AD cohort to non-AD cohort hazard ratios (HRs) and confidence intervals (CIs) were measured. Comparison of renal involvement in HSP between children with and without AD was analyzed.The incidence of HSP during the study period was 1.75-fold greater (95% CI: 1.27–2.42) in the AD cohort than in the non-AD cohort (14.2 vs 8.11 per 100,000 person-years). The AD to non-AD HR of HSP was greater for girls (1.92, 95% CI: 1.18–3.13), children older than 6 years (2.54, 95% CI: 1.15–5.59), and those living in less urbanized area (2.74, 95% CI: 1.10–6.82). Concurrent allergic rhinitis or asthma did not increase the HR of HSP further. The HR for HSP in AD children increased from 0.67 (95% CI: 0.41–1.11) for those with ≤2 AD-related visits to 9.77 (95% CI: 6.44–14.8) for those with >4 visits (P < 0.0001, by the trend test). The risk of developing HSP in the AD cohort was highest within first year after AD diagnosis (HR: 3.99; 95% CI: 1.61–9.89). AD cohort with HSP had higher occurrence rate of renal involvement, particular hematuria, than non-AD cohort with HSP.AD children had a greater risk of developing HSP and HSP with renal involvement. Further research is needed to clarify the role of allergy in the pathogenesis of HSP and renal involvement.

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“…The children file (age < 18 y) was derived from the NHIRD and is maintained by the National Health Research Institutes. The children file includes the claims data of 50% children randomly selected from the pediatric population enrolled during 1996−2008 (34)(35)(36)(37). Diseases are coded on the basis of the International Classification of Diseases, Ninth Revision, Clinical Modification (ICD-9-CM).…”

Section: Data Sourcesmentioning

confidence: 99%

Neonatal jaundice and risks of childhood allergic diseases: a population-based cohort study

et al. 2015

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Background:Only a few studies have systemically analyzed the association between neonatal jaundice and childhood-onset allergic diseases. Methods: From 2000 to 2007, 27,693 neonates with newly diagnosed neonatal jaundice and 55,367 matched nonneonatal jaundice cohorts were identified. The incidences and hazard ratios (HRs) of five allergic diseases, namely allergic conjunctivitis (AC), allergic rhinitis (AR), atopic dermatitis (AD), asthma, and urticaria, by the end of 2008 were calculated. results: The incidence density and HRs of the five allergic diseases were greater in the neonatal jaundice cohort than in the nonneonatal jaundice cohort, and the HRs declined modestly with age. The HRs for AR (HR = 2.51, 95% confidence interval (CI) = 2.43-2.59) and AD (HR = 2.51, 95% CI = 2.40-2.62) were the highest, and that for urticaria was the lowest (HR = 2.06, 95% CI = 1.94-2.19). The HRs of allergic diseases were substantially greater for boys and those requiring phototherapy. The HRs of the allergic diseases, except urticaria (HR = 2.49, 95% CI = 1.57-3.97), were not significantly different between the neonatal jaundice regardless of whether the patients received exchange transfusion. conclusion: Neonatal jaundice is associated with the development of allergic diseases in early childhood.

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Increased risk of idiopathic nephrotic syndrome in children with atopic dermatitis

Abstract: Children with AD have a greater incidence and risk of developing INS and this risk increases with AD severity.

Cited by 31 publications

References 30 publications

Synaptopodin is upregulated by IL-13 in eosinophilic esophagitis and regulates esophageal epithelial cell motility and barrier integrity

Synaptopodin is upregulated by IL-13 in eosinophilic esophagitis and regulates esophageal epithelial cell motility and barrier integrity

Atopic Dermatitis and Association of Risk for Henoch–Schönlein Purpura (IgA Vasculitis) and Renal Involvement Among Children

Neonatal jaundice and risks of childhood allergic diseases: a population-based cohort study

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