Increased risk of incident nasopharyngeal carcinoma with exposure to air pollution

Fan, Hueng Chuen; Chen, Chiu Ying; Hsu, Yi‐Chao; Chou, Ruey Hwang; Teng, Chieh Lin Jerry; Chiu, Chun Hsiang; Hsu, Chung Y.; Muo, Chih Hsin; Chang, Mei Yin; Chang, Kuang-Hsi

doi:10.1371/journal.pone.0204568

Cited by 29 publications

(30 citation statements)

References 36 publications

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“…For every 1% increase in NO 2 concentrations, the overall NPC incidence increases by at least 1.706%, and the overall NPC incidence growth rate increases by at least 5.598%. These findings are consistent with previous studies who reported that NO 2 displayed the strongest association with NPC incidence, or CBD (Cerebrovascular Disease) and CVD (Cardiovascular Disease) mortality, as compared to SO 2 and PM 10 [2,15]. The harmful effect of indoor air pollution can support our finding from another perspective: An increased NPC risk has been found associated with daily incense burning (Adjusted OR = 2.49, 95% CI: 1.33-4.66) in women, and the adjusted OR for daily burning with good ventilation (1.35, 95% CI: 0.92-1.98) is much lower than that with poor ventilation (2.08, 95% CI: 1.02-4.24) [45].…”

Section: Discussionsupporting

confidence: 93%

Association of Ambient Air Pollution with Nasopharyngeal Carcinoma Incidence in Ten Large Chinese Cities, 2006–2013

Yang

Liu

Zhao

et al. 2020

IJERPH

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Large cities in China are experiencing severe ambient air pollution. Although China accounts for more than 45% of new cases of nasopharyngeal carcinoma worldwide in 2018, few studies have examined the association between ambient air pollution and the high nasopharyngeal carcinoma (NPC) incidence in China. Thus, we aim to investigate whether exposure to ambient air pollution (including nitrogen dioxide, sulfur dioxide, and PM10) would significantly affect NPC incidence in large Chinese cities. We collected panel data of ten Chinese provincial cities about local NPC incidence, air pollution level, meteorology, and city profiles during 2006 to 2013 to construct a two-way fixed-effects model to explore the association between ambient air pollution and NPC incidence, as well as possible regional and gender differences behind the association. We found that NO2 had the strongest association with NPC incidence, and the relative risks were 2.2995 (95% CI, 1.2567–4.2075) for males and 1.3010 (95% CI, 0.8212–2.0620) for females, respectively. Under cumulative exposure, it was still NO2 that had the strongest association with NPC incidence, with a relative risk of 1.8836 (95% CI, 1.2416–2.8577), compared to 1.0857 (95% CI, 0.9474–1.2450) and 1.0547 (95% CI, 0.8790–1.2663) for SO2 and PM10, respectively. In addition, males were found more sensitive to ambient air pollution than females. We also found that southern Chinese cities were more sensitive to NO2 than northern cities, which might be related to a higher humidity there. Our study reveals that exposure to ambient air pollutants like SO2, PM10, and particularly NO2, is significantly positively associated with NPC incidence in China.

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Section: Discussionsupporting

confidence: 93%

Association of Ambient Air Pollution with Nasopharyngeal Carcinoma Incidence in Ten Large Chinese Cities, 2006–2013

Yang

Liu

Zhao

et al. 2020

IJERPH

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“…Several studies investigating the clinical effects of air pollution on different organ systems in the human body have been conducted [4,[7][8][9]11,53]. Using similar datasets, we have previously shown that CO and NO 2 were associated with AMD [11], dementia [53], and PD [9].…”

Section: Discussionmentioning

confidence: 84%

“…Primarily, lung cancer is considered the major severe disease caused by air pollution [1,2]. Notably, accumulating evidence shows that chronic exposure to air pollution is associated with not only respiratory diseases but also non-lung cancers [3,4] and cardiovascular [5,6], inflammatory [7,8], and neurodegenerative diseases [9,10] including age-related macular degeneration (AMD) [11].…”

Section: Introductionmentioning

confidence: 99%

Increased Risk of Sensorineural Hearing Loss as a Result of Exposure to Air Pollution

Chang

Tsai

Lee

et al. 2020

IJERPH

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Whether exposure to air pollution is associated with developing sensorineural hearing loss (SHL) remains controversial. Using data from the National Health Insurance Research Database, we recruited a total of 75,767 subjects aged older than 20 years with no history of SHL from 1998 to 2010, and they were followed up until SHL was observed, they withdrew from the National Health Insurance program, or the study ended. The subjects were evenly exposed to low-level, mid-level, and high-level carbon monoxide (CO) and nitrogen dioxide (NO2). The incidence rate ratio of SHL for patients exposed to high-level CO was 1.24 (95% confidence interval (CI) = 1.14–1.36). The NO2 pollutants increased the incidence rate ratios of SHL in mid-level NO2 and high-level NO2 exposures by 1.10 (95% CI = 1.10–1.32) and 1.36 (95% CI = 1.24–1.49) times, respectively. The adjusted hazard ratio (adj. HR) of SHL in patients exposed to high-level CO was 1.45 (95% CI = 1.31–1.59), relative to that of patients exposed to low-level CO. Compared to patients exposed to low-level NO2, patients exposed to mid-level NO2 (adj. HR = 1.40, 95% CI = 1.27–1.54) and high-level NO2 (adj. HR = 1.63, 95% CI = 1.48–1.81) had a higher risk of developing SHL. The increased risk of SHL following the increased concentrations of air pollutants (CO and NO2) was statistically significant in this study. In conclusion, the subjects’ exposure to air pollution exhibited a significantly higher risk of developing SHL in Taiwan.

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“…Der Endpunkt Kanzerogenität wurde auch in epidemiologischen Studien und Metaanalysen analysiert [113][114][115][116][117]. Auch in diesen Studien ist die NO 2 -Konzentration als Marker für Verkehrsemissionen zu verstehen, so dass die zum Teil gefundenen signifikanten Assoziationen zu erhöhten NO 2 -Konzentrationen für die ursächliche Bewertung nicht herangezogen werden können.…”

Section: Mutagenität Und Kanzerogenitätunclassified

Richtwerte für Stickstoffdioxid (NO2) in der Innenraumluft

2019

Bundesgesundheitsbl

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Increased risk of incident nasopharyngeal carcinoma with exposure to air pollution

Cited by 29 publications

References 36 publications

Association of Ambient Air Pollution with Nasopharyngeal Carcinoma Incidence in Ten Large Chinese Cities, 2006–2013

Association of Ambient Air Pollution with Nasopharyngeal Carcinoma Incidence in Ten Large Chinese Cities, 2006–2013

Increased Risk of Sensorineural Hearing Loss as a Result of Exposure to Air Pollution

Richtwerte für Stickstoffdioxid (NO2) in der Innenraumluft

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