Increased risk of invasive bacterial infections in African people with sickle-cell disease: a systematic review and meta-analysis

Ramakrishnan, Meenakshi; Moïsi, Jennifer C; Klugman, Keith P.; Iglesias, Jesus M Feris; Grant, Lindsay R.; Mpoudi-Etame, Mireille; Levine, Orin S.

doi:10.1016/s1473-3099(10)70055-4

Cited by 100 publications

(77 citation statements)

References 32 publications

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“…13 Although this study did not take into account issues of race, we can say that the socio- In sickle cell disease there are few specific therapeutic options, 18,19,20 being fundamental institution of general and preventive measures to lessen the consequences of chronic anemia, sickle cell crises, and susceptibility to infections. 21,22 Patients with sickle cell disease have chronic hemolysis, and in an attempt to compensate the anemia, there is an increased production of red blood cells, which consume folic acid, so it is recommended that supplementation with 1-2 mg of folate daily. With respect to drug therapy of patients studied, most reported about using folic acid.…”

Section: Discussion Discussion Discussion Discussionmentioning

confidence: 99%

“…Patients with sickle cell disease have increased susceptibility to infections by capsulated organisms, mainly due to loss of splenic function (auto-splenectomy) due to frequent thrombosis and infarction, 22 thus, it is recommended prophylaxis with penicillin for all children with sickle cell disease, should be made from three months to five years old. You can use either orally (penicillin V) or parenteral (benzathine penicillin).…”

Section: Discussion Discussion Discussion Discussionmentioning

confidence: 99%

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Avaliação da qualidade de vida em pacientes com anemia falciforme: diferenças entre adultos e crianças

Losilla¹,

Miranzi²,

Lima³

et al. 2013

Medicina (Ribeirão Preto)

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A anemia falciforme é uma das doenças hereditárias mais comuns em todo o mundo. Acredita-se que a qualidade de vida (QV) do paciente com a doença falciforme é muito baixa e que suas condições socioeconômicas e culturais indicam deficiências em vários aspectos. O objetivo deste estudo foi descrever e analisar a QV dos pacientes com anemia falciforme assistidos em um ambulatório de hematologia de um hospital de ensino no sudeste do Brasil. Este é um estudo transversal com aplicação do instrumento WHOQOL-BREF em adultos (grupo 1) e crianças (grupo 2) com anemia falciforme. No cálculo de diferenças entre proporções foi utilizado o teste do qui-quadrado. Para verificar diferenças entre as médias foi utilizado o teste t de Student para amostras independentes. Para análise da associação entre as variáveis, foi empregada a razão de prevalência (RP) com seu intervalo de confiança a 95% (IC95%), como estimadores de magnitude. Considerou-se um nível de significância de 5% em todas as análises. No grupo 1 foram selecionados 27 pacientes (54%) com média de idade de 27,2 anos, sendo 58,3% do sexo feminino, enquanto que no grupo 2 foram 23 crianças (46%), cuja média de idade foi de 8,7 anos, com 57,1% da amostra do sexo masculino. A QV foi maior entre os pacientes do grupo 2 nos domínios físicos e ambiental (p<0,05). A população estudada apresentou uma QV favorável, com valores médios acima de 11 em todos os domínios. Pacientes com idade ? 13 anos apresentaram melhor QV em relação aos com idade > 13 anos, possivelmente indicando melhor funcionalidade e menos conflitos emocionais e psicológicos.

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Section: Discussion Discussion Discussion Discussionmentioning

confidence: 99%

Section: Discussion Discussion Discussion Discussionmentioning

confidence: 99%

Avaliação da qualidade de vida em pacientes com anemia falciforme: diferenças entre adultos e crianças

Losilla¹,

Miranzi²,

Lima³

et al. 2013

Medicina (Ribeirão Preto)

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“…Although incidence of IPD caused by PCV7-types was nearly eliminated in blacks and whites after PCV7 was introduced, rates of non-PCV7-type IPD increased in both races so that, by 2009, non-PCV7-type IPD incidence among blacks was still much higher than that among whites, in all age groups (15). Research has suggested that these findings may be due to a higher prevalence of underlying conditions among blacks (e.g., asthma, diabetes, HIV/AIDS) and lower SES (16)(17)(18).…”

Section: Ipd (Streptococcus Pneumoniae)mentioning

confidence: 99%

Emerging Infections Program Efforts to Address Health Equity

Hadler¹,

Vugia²,

Bennett³

et al. 2015

Emerg. Infect. Dis.

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The Emerging Infections Program (EIP), a collaboration between (currently) 10 state health departments, their academic center partners, and the Centers for Disease Control and Prevention, was established in 1995. The EIP performs active, population-based surveillance for important infectious diseases, addresses new problems as they arise, emphasizes projects that lead to prevention, and develops and evaluates public health practices. The EIP has increasingly addressed the health equity challenges posed by Healthy People 2020. These challenges include objectives to increase the proportion of Healthy People-specified conditions for which national data are available by race/ethnicity and socioeconomic status as a step toward first recognizing and subsequently eliminating health inequities. EIP has made substantial progress in moving from an initial focus on monitoring social determinants exclusively through collecting and analyzing data by race/ethnicity to identifying and piloting ways to conduct population-based surveillance by using area-based socioeconomic status measures.

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“…It is well known that patients with SCD are at an increased risk for overwhelming systemic bacterial infections with S. pneumoniae, H. influenzae, N. meningitidis, and Salmonellae [1,2]. Current guidelines suggest treating with broad spectrum antibiotics any child with SCD who presents with a fever >38.3-38.9°C (>101-102°F) [3,4] time, there is a growing concern about antibiotic overuse, so that many institutions have instituted antibiotic stewardship programs [5].…”

Section: Introductionmentioning

confidence: 99%

Usefulness of the C-Reactive Protein in Predicting the Need for Antibiotics Among Febrile Inpatients with Sickle Cell Disease

Gershel¹,

Kreiner²,

Spitzer³

et al. 2015

TOIDJ

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Abstract:Objective: To determine whether the C-reactive protein (CRP) can help identify which febrile patients with sickle cell disease (SCD) require antibiotic therapy. Patients and Methods:We performed a chart review of patients with SCD (including S-S, S-C, and S-Thal) admitted to the hospital with fever [temperature >38.3 o C <2 years of age; >38.9 o C ≥2 years of age] over a thirty-month period (July 2009 -December 2011). Data extracted included temperature, age, high sensitivity CRP value, chest x-ray and culture results, and the underlying cause of fever, categorized as bacterial (antibiotics necessary) or non-bacterial (antibiotics not necessary). The Mann-Whitney U-test was then used to compare the median CRP levels of patients requiring antibiotics versus those whose illnesses did not require antibiotic treatment.Results: Fifty-four febrile patients with SCD were admitted to the hospital. Nineteen had final diagnoses that required antibiotic treatment and their median CRPs were significantly higher than the thirty-five who had diagnoses that did not meet the requirements for antibiotic treatment (100.9 mg/L vs 17.3 mg/L, p <.001). All patients who needed antibiotics had a CRP >39 mg/L. Conclusion:The current data indicate that among febrile patients with SCD, the CRP may help differentiate bacterial infections which require antibiotic treatment from other diseases for which antibiotics are not necessary. Our data suggests that there may be a level of CRP below which a bacterial etiology is unlikely.

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Increased risk of invasive bacterial infections in African people with sickle-cell disease: a systematic review and meta-analysis

Cited by 100 publications

References 32 publications

Avaliação da qualidade de vida em pacientes com anemia falciforme: diferenças entre adultos e crianças

Avaliação da qualidade de vida em pacientes com anemia falciforme: diferenças entre adultos e crianças

Emerging Infections Program Efforts to Address Health Equity

Usefulness of the C-Reactive Protein in Predicting the Need for Antibiotics Among Febrile Inpatients with Sickle Cell Disease

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