Increased risk of Kawasaki disease in children with common allergic diseases

Wei, Chang; Lin, Cheng Li; Kao, Chia Hung; Liao, Yen Hsiu; Shen, Te Chun; Tsai, Jeng Dau; Chang, Yen Jung; Li, Tsai‐Chung

doi:10.1016/j.annepidem.2014.02.003

Cited by 43 publications

(40 citation statements)

References 22 publications

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“…The children file (age < 18 y) was derived from the NHIRD and is maintained by the National Health Research Institutes. The children file includes the claims data of 50% children randomly selected from the pediatric population enrolled during 1996−2008 (34)(35)(36)(37). Diseases are coded on the basis of the International Classification of Diseases, Ninth Revision, Clinical Modification (ICD-9-CM).…”

Section: Data Sourcesmentioning

confidence: 99%

“…The NHIRD, a population-based database, is maintained by the National Health Research Institutes and is derived from the claims data of the NHI program, a mandatory-enrollment, single-payment system created in 1995 and now covering over 99% of the Taiwanese population (http://www.nhi.gov.tw/english/index.aspx) (36). The children file (age < 18 y) was derived from the NHIRD and is maintained by the National Health Research Institutes.…”

Section: Data Sourcesmentioning

confidence: 99%

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Neonatal jaundice and risks of childhood allergic diseases: a population-based cohort study

et al. 2015

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Background:Only a few studies have systemically analyzed the association between neonatal jaundice and childhood-onset allergic diseases. Methods: From 2000 to 2007, 27,693 neonates with newly diagnosed neonatal jaundice and 55,367 matched nonneonatal jaundice cohorts were identified. The incidences and hazard ratios (HRs) of five allergic diseases, namely allergic conjunctivitis (AC), allergic rhinitis (AR), atopic dermatitis (AD), asthma, and urticaria, by the end of 2008 were calculated. results: The incidence density and HRs of the five allergic diseases were greater in the neonatal jaundice cohort than in the nonneonatal jaundice cohort, and the HRs declined modestly with age. The HRs for AR (HR = 2.51, 95% confidence interval (CI) = 2.43-2.59) and AD (HR = 2.51, 95% CI = 2.40-2.62) were the highest, and that for urticaria was the lowest (HR = 2.06, 95% CI = 1.94-2.19). The HRs of allergic diseases were substantially greater for boys and those requiring phototherapy. The HRs of the allergic diseases, except urticaria (HR = 2.49, 95% CI = 1.57-3.97), were not significantly different between the neonatal jaundice regardless of whether the patients received exchange transfusion. conclusion: Neonatal jaundice is associated with the development of allergic diseases in early childhood.

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Section: Data Sourcesmentioning

confidence: 99%

Section: Data Sourcesmentioning

confidence: 99%

Neonatal jaundice and risks of childhood allergic diseases: a population-based cohort study

et al. 2015

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“…Webster et al [15] showed that atopic tendency existed prior to the onset of KD and was also persistent among family members of KD patients. Wei et al [16] reported the OR for developing KD among atopic patients. In their study, patients with urticaria had the highest risk, followed by patients with allergic rhinitis and atopic dermatitis (OR 1.8, 1.44 and 1.22, respectively).…”

Section: Discussionmentioning

confidence: 99%

Atopic Predilection among Kawasaki Disease Patients: A Cross-Sectional Study of 1,187,757 Teenagers

Hassidim

Merdler²,

Chorin

et al. 2016

Int Arch Allergy Immunol

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Background: Kawasaki disease (KD) is an acute, systemic vasculitis in children, with an etiology that is not completely understood. It is assumed that the development of KD is mediated by an immunologic response. Several reports from East Asia have found a higher prevalence of atopic diseases among patients with KD, but a large-scale study of a non-Asian population regarding this correlation is still lacking. The purpose of this article was to achieve this goal. Methods: We conducted a cross-sectional, large-scale study to estimate the correlation of KD with allergic diseases. The medical history of 1,187,757 Israeli teenagers (aged 16-20 years during the years 1998-2013) was retrieved. The study population was divided into 3 groups according to a past history of noncomplicated and complicated KD and a control group. The prevalence of allergic diseases among these groups was further investigated. Results: The prevalence of atopic diseases in the 3 study groups was presented (asthma in 11.4, 8.1 and 3.5%, respectively; angioedema/urticaria in 7.1, 0 and 0.46%, respectively; allergic rhinitis in 20, 12.1 and 6.7%, respectively). In noncomplicated KD, a statistically significant link to asthma [odds ratio (OR) 2.4; p = 0.048] and a borderline significant link to allergic rhinitis (OR 1.9; p = 0.06) were found. In KD complicated with cardiac disease, statistically significant links were found for all the allergic conditions, asthma (OR 3.5; p = 0.003), allergic rhinitis (OR 3.5; p < 0.001) and angioedema/urticaria (OR 16.48; p < 0.001). Conclusion: KD is associated with allergic diseases. This association increases with the severity of the disease.

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“…İlginç olarak, dikkat eksikliği hiperaktivite bozukluğu olan hastaların da %75'inde AR semptomları izlenmekte ve %69'unda DPT pozitif bulunmaktadır (30). Herhangi bir allerjik hastalığa sahip olmanın Kawasaki hastalığı geliştirme riskini (1.4 kat) artırdığı bilinmektedir (31). Yine AR'li hastalarda nazofaringeal karsinoma gelişme riskinde artış mevcuttur (32).…”

Section: Ko-morbiditelerunclassified

New Developments in the Diagnosis and Therapy of Allergic Rhinitis

Özdemir¹,

Elmas²

2017

Asthma Allergy Immunol

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ÖZAllerjik rinit (AR) tüm yaş gruplarında görülen en sık ve kronik hastalıklardan biridir. Allerjik rinit IgE-aracılı nazal havayolunun allerjik enflamasyounu olup hapşırık, gözde kaşıntı-sulanma, burun mukozasının şişlik ve enflamasyonu ile kendini gösterir. Küresel sağlık problemi ve çocukluktan erişkinliğe kadar birçok kişiyi etkileyen ağır bir hastalıktır. Dünyada çocukluk çağı AR prevalansı %0.8 -45 arasında değişmektedir. Türkiye' de değişik bölgelerde sıklığı %2.9-44 olarak bildirilmektedir. Derlememizin amacı AR teşhis ve tedavisinde güncel tedavi ve teşhis yöntemlerini anlatmaktır. Hastalığın astım üzerine ve hastanın hayatına etkisinden dolayı AR en güvenilir ve etkin tedavi yöntemleriyle tedavi edilmelidir. İkinci kuşak antihistaminikler ve intranazal steroidler tedavinin temel taşlardır. Fakat mevcut ilaçların yeni formülasyonları (rupatadin oral solusyonu, hızlı çözünen ebastin tablet ve intranazal flutikazon propionat ve azelastin hidroklorit kombinasyonu vb.), yeni keşfedilmiş moleküller (siklesonid, bilastin, roflumilast vb.), immünolojik hedefi olan tedaviler (omalizumab gibi) ve klasik olmayan tedaviler (homeopatik yöntemler gibi) AR tedavisinde yeni ufukları temsil etmektedir. Allerjik rinitin doğru teşhis edilmesi tedavi başarısında esastır. Teşhiste ümit verici gelişmeler özgün risk molekülünü tanıyan rekombinant allerjenleri kullanan teşhis yöntemlerinden beklenmektedir. Hastaların duyarlı olduğu kişisel molekülleri tanımlayan pür doğal ve rekombinan allerjenler moleküler ya da belirlenmiş komponentin teşhis yöntemiyle saptanabilir. Böylece, belirlenmiş komponente dayalı teşhis yöntemi provokasyon testine olan ihtiyacı azaltabilir ve allerjen immünoterapisinin özgünlüğünü artırabilir. Yine teşhiste, nazal nitrik oksit (nNO) düzeyini ölçmekte günümüzde değişik yöntemler vardır. Azalmış nNO, kistik fibroz için tipik olmakla beraber, primer silyer diskinezide olduğu kadar düşük değildir. nNO'nun AR gibi üst solunum yolu hastalıklarında klinikte kullanımı yaygınlaşmamıştır. ABSTRACTAllergic rhinitis (AR) is one of the most common chronic diseases in all age groups. It is an IgE-mediated allergic inflammation of the nasal airways and is characterized by sneezing, swelling and inflammation of the nasal mucosa as well as itchy and watery eyes. It is a global health problem and a burdensome disorder affecting many people from childhood to adulthood. The prevalence of childhood AR shows wide variation throughout the world, ranging from 0.8 to 45%. The prevalence rates for different regions of Turkey ranges from 2.9 to 44%. The aim of the present review is to provide an update on AR treatment and diagnosis. Because of its burden on patient's lives and its impact on asthma, AR should be taken care of properly with effective and safe treatments. Second-generation antihistamines and intranasal steroids represent the milestone of AR therapy. New formulations of available drugs (rupatadine oral solution, ebastine fast-dissolving tablets, combination of intranasal fluticasone propionate and azelastine hydr...

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Increased risk of Kawasaki disease in children with common allergic diseases

Cited by 43 publications

References 22 publications

Neonatal jaundice and risks of childhood allergic diseases: a population-based cohort study

Neonatal jaundice and risks of childhood allergic diseases: a population-based cohort study

Atopic Predilection among Kawasaki Disease Patients: A Cross-Sectional Study of 1,187,757 Teenagers

New Developments in the Diagnosis and Therapy of Allergic Rhinitis

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