Increased risk of lymphoproliferative disorders in relatives of patients withB‐cell chronic lymphocytic leukemia: relevance of the degree of familial linkage

Capalbo, Silvana; Trerotoli, Paolo; Ciancio, Angela; Battista, Cosima; Serio, Gabriella; Liso, Vincenzo

doi:10.1034/j.1600-0609.2000.90183.x

Cited by 39 publications

(26 citation statements)

References 8 publications

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“…[1][2][3][4][5][6][7][8][9][10][11] Similar findings have been reported for Hodgkin's lymphoma (HL) [12][13][14][15][16][17][18][19][20][21][22][23] and nonHodgkin's lymphoma (NHL). 1,9,20,22,[24][25][26][27][28][29] Populationbased studies have found CLL, HL, and NHL to co-occur in families, 1,3,5,9,20,21,[23][24][25][26][27][28][29][30][31] suggesting that shared genetic pathways may contribute to risk for multiple lymphoproliferative malignancies.…”

Section: Introductionsupporting

confidence: 73%

“…[1][2][3]5,[8][9][10] However, few studies have investigated whether having a family history of lymphoma impacts prognosis. A study based on 126 patients with CLL reported that mean survival of patients with CLL with a family history of malignancy was higher compared with patients without a family history of malignancy 55 ; however, the investigators failed to characterize malignancy type in the family members.…”

Section: Discussionmentioning

confidence: 99%

“…Family history of lymphoma is a well-known risk factor for developing lymphoma. [1][2][3][4][5][6][7][8][9][10][11] The influence of family history on lymphoma outcome has, until recently, been obscure and based on small series.…”

Section: Survival In Familial Lymphomamentioning

confidence: 99%

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Survival Patterns Among Lymphoma Patients With a Family History of Lymphoma

Anderson

Pfeiffer

Rapkin

et al. 2008

JCO

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A B S T R A C T PurposeGenetic factors are important in the etiology and pathogenesis of chronic lymphocytic leukemia (CLL), Hodgkin's lymphoma (HL), and non-Hodgkin's lymphoma (NHL). Only a few small studies have assessed clinical characteristics and prognosis for familial patients, with inconsistent findings. MethodsUsing population-based registries from Sweden and Denmark, 7,749 patients with CLL, 7,476 patients with HL, and 25,801 patients with NHL with linkable first-degree relatives were identified. Kaplan-Meier curves were constructed to compare survival in patients with lymphoma with and without a family history of lymphoma. The risk of dying was assessed using adjusted Cox proportional hazard models. ResultsWe found 85 patients with CLL (1.10%), 95 patients with HL (1.28%), and 206 patients with NHL (0.80%) with a family history of any lymphoma. Five-year mortality was similar for patients with CLL (hazard ratio [HR], 1.28; 95% CI, 0.95 to 1.72), HL (HR, 0.78; 95% CI, 0.49 to 1.25), and NHL (HR, 0.91; 95% CI, 0.74 to 1.12) versus without a family history of any lymphoma. Mortality was also similar for patients with versus without a family history of the same lymphoma. T-cell/ anaplastic lymphoma patients with a family history of NHL had poorer outcome 5-years after diagnosis (HR, 5.38; 95% CI, 1.65 to 17.52). Results were similar for 10 years of follow-up. ConclusionWith the exception of T-cell/anaplastic lymphoma, survival patterns for patients with CLL, HL, and NHL with a family history of lymphoma were similar to those for sporadic patients, suggesting that most familial lymphomas do not have an altered clinical course. Our findings provide no evidence to modify therapeutic strategies for patients with CLL, HL, or NHL based solely on family history. J Clin

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Section: Introductionsupporting

confidence: 73%

Section: Discussionmentioning

confidence: 99%

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Survival Patterns Among Lymphoma Patients With a Family History of Lymphoma

Anderson

Pfeiffer

Rapkin

et al. 2008

JCO

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“…Families with what appears to be Mendelian autosomal dominant inheritance of CLL are not uncommon in the literature [Brown et al 2012a;Caporaso et al 2004;Jonsson et al 2005;Sellick et al 2006]. In fact, approximately 12% of patients with CLL report a family history of a lymphoproliferative disorder (LPD) [Brown et al 2008a], and 6-9% have a relative who also has CLL [Capalbo et al 2000;Mauro et al 2006;Yuille et al 1998]. Not surprisingly, then, the risk of developing CLL is also increased in first-degree relatives of CLL patients.…”

Section: Inherited Predisposition To Cllmentioning

confidence: 99%

Inherited susceptibility to chronic lymphocytic leukemia: evidence and prospects for the future

Brown

2013

Therapeutic Advances in Hematology

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Chronic lymphocytic leukemia (CLL) is the most common leukemia in the United States and one of the most heritable cancers. A family history of the disease is perhaps the best defined risk factor, and approximately 15–20% of CLL patients have a family member with CLL or a related lymphoproliferative disorder. Much effort has been devoted to trying to elucidate the mechanisms underlying this genetic risk. Familial CLL appears to be clinically and biologically similar to sporadic CLL, and most if not all CLL appears to be preceded by monoclonal B-cell lymphocytosis (MBL), which does appear to occur at higher frequency in relatives in families with CLL. Neither linkage studies nor candidate gene association studies have proven particularly informative in CLL, but genomewide association studies have identified multiple low-risk variants that together explain about 16% of the familial risk of CLL. Studies of individual families have identified higher-risk single nucleotide polymorphisms or copy number variants associated with disease risk in those families. Current efforts to identify additional risk loci are focused on applying next-generation sequencing to the germline of informative CLL families as well as individuals with sporadic CLL.

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“…[1][2][3][4] The detection of a CLL-associated marker in healthy relatives of patients with familial CLL may provide a surrogate marker of inherited predisposition, assisting in the identification of causative gene mutations. It is possible to identify markers of some B-cell malignancies in healthy persons, including the follicular lymphoma-associated t(14;18) translocation 5,6 and the neoplastic plasma cells common to myeloma and monoclonal gammopathy of undetermined significance (MGUS).…”

Section: Introductionmentioning

confidence: 99%

Erratum for vol. 100, p. 1404

2002

Blood

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Increased risk of lymphoproliferative disorders in relatives of patients withB‐cell chronic lymphocytic leukemia: relevance of the degree of familial linkage

Cited by 39 publications

References 8 publications

Survival Patterns Among Lymphoma Patients With a Family History of Lymphoma

Survival Patterns Among Lymphoma Patients With a Family History of Lymphoma

Inherited susceptibility to chronic lymphocytic leukemia: evidence and prospects for the future

Erratum for vol. 100, p. 1404

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