Increased Risk of Oral Cancer in Patients With Inflammatory Bowel Diseases

Κατσάνος, Κωνσταντίνος; Roda, Giulia; McBride, Russell; Cohen, Benjamin L.; Colombel, Jean–Frédéric

doi:10.1016/j.cgh.2015.09.041

Cited by 27 publications

(41 citation statements)

References 34 publications

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“…6 Moreover, Crohn disease also raises the risk of multiple other malignancies, including cutaneous SCCs and urothelial carcinomas, with a standardized incidence ratio of 2.4 and 2.0, respectively. 6 A recent case series by Katsanos et al 10 also suggested an increased risk for oral cancer, although no Crohn disease patients in their series exhibited any oral involvement as an extraintestinal manifestation.…”

Section: Discussionmentioning

confidence: 91%

Managing Head and Neck Malignancy Arising in a Field of Crohn Disease Inflammation: Report of a Case

et al. 2017

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Some of the clinical characteristics of Crohn disease of the head and neck overlap those of squamous cell carcinoma of the head and neck. We describe the diagnostic and therapeutic complexities we encountered in an unusual case of piriform sinus cancer that had arisen in a field of pharyngeal Crohn disease. Based on our initial failure to recognize the predominant inflammatory component of the lesion, we discuss the special considerations that must be made for the detection, staging, and management of head and neck cancer in Crohn disease patients. We further describe the multiple potential interactions among smoking, inflammation, and immunosuppression therapy in the colocalized pathogenesis of the two disease states.

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Section: Discussionmentioning

confidence: 91%

Managing Head and Neck Malignancy Arising in a Field of Crohn Disease Inflammation: Report of a Case

et al. 2017

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“…Out of the 11 cases, 3 were reported as sarcoma. 10 No association with immunosuppressive therapy was reported. In our case, no prolonged systemic immunosuppressive therapy was needed to control IBD symptoms, and the patient was symptom-free for 5 years before her sarcoma diagnosis.…”

Section: Discussionmentioning

confidence: 99%

“…Patients with IBD might also have an increased risk of developing thyroid, 8 breast, 9 and oral cancer 10 although the potential underlying mechanisms remain unknown. Several case reports 11 - 13 of sarcomas arising in the context of immunosuppressant therapy for IBD have raised the question whether an increased risk for the development of soft tissue tumors exists in IBD patients.…”

Section: Introductionmentioning

confidence: 99%

Pleomorphic undifferentiated soft tissue sarcoma in patient with long standing inflammatory bowel disease

Labinac-Peteh

Terlevic²,

Krušlin

2018

Autops. Case Rep.

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Inflammatory bowel disease (IBD) has been associated with the development of both gastrointestinal and extraintestinal malignancy. The role of therapy in the development of malignancy in IBD has been controversial. We present the case of a 40-year-old female patient with long-standing mild IBD, who developed an undifferentiated pleomorphic sarcoma of the inguinal region and provide a brief review of the relevant literature. While our case likely represents a coincidence of two unrelated pathological entities, clinicians should keep in mind the possibility of soft tissue sarcomas in patients chronically treated with anti-inflammatory agents.

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“…12,[15][16][17] Multiple studies have shown an association between oral disease and IBD, including pathogenesis of the disease as well as a contributing factor of disease complications, such as malignancies. A recent publication showed that oral cancer is increased in patients with IBD, 18 but this needs to be studied further and the mechanisms will need to be elucidated further. Regarding the association of disease pathogenesis and disease activity, several publications have shown oral hygiene to be an important factor.…”

Section: Is This Consistent With Prior Studies In the Literature?mentioning

confidence: 99%