Increased risk of oropharyngeal cancers mediated by oral human papillomavirus infection: Results from a Canadian study

Laprise, Catherine; Madathil, Sreenath; Castonguay, Geneviève; Soulières, Denis; Nguyen-Tân, Phuc Félix; Coutlée, François; Hier, Michael P.; Rousseau, Marie‐Claude; Franco, Eduardo L.; Nicolau, Bélinda

doi:10.1002/hed.25436

Cited by 11 publications

(11 citation statements)

References 41 publications

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“…The patients with HPVpositive HNSCCs tended to be younger, white, men, and individuals with local T category and poorly differentiated tumors (Li et al, 2018). Sexual behaviors such as oral sex practice and having multiple lifetime number of oral or genital sexual partners were associated with these cases (Emmett et al, 2018;Laprise et al, 2019). Regarding the prognosis, a significantly better survival and treatment response were observed among those with HPV infection (Li et al, 2018;Tian et al, 2019).…”

Section: Human Papillomavirus 16 and 18 Infection In Oral Cancer In Tmentioning

confidence: 99%

Human Papillomavirus 16 and 18 Infection in Oral Cancer in Thailand: A Multicenter Study

Komolmalai

Pongsiriwet

Lertprasertsuke

et al. 2020

Asian Pac J Cancer Prev

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Objectives: To identify the prevalence of high-risk human papillomavirus (HPV) genotypes 16 and 18 among patients with oral squamous cell carcinoma (OSCC) in Thailand and investigate the associations of p16 expression and HPV16/18 with the demographic, clinicopathologic, and risk parameters. Materials and Methods: A total of 403 formalin-fixed paraffin-embedded OSCC specimens from four centers in four regions were obtained. p16 expression was evaluated by immunohistochemistry. The detection of HPV16/18 DNA was performed by polymerase chain reaction. Results: Of all, 172 specimens (42.7%) were presented with amplifiable extracted DNA. Among these, 62.8% were positive for p16, 8.1% were positive for HPV16/18, and 5.8% were positive for both methods. Of all HPV-positive specimens, HPV18 was detected in 57.1%; HPV16 in 14.3%; and HPV16 and 18 (co-infection) in 28.6%. The prevalence of HPV16/18 varied between centers, with the highest rate in the northern center (20.0%). There was no significant correlation between p16 expression and HPV16/18. There were no significant associations of p16 expression and/or HPV16/18 with all variables. Conclusions: The prevalence of HPV16/18 infection in OSCC geographically varied in Thailand, with the highest rate in the northern region. Poor correlation between p16 and HPV16/18 suggests p16 not be used as a surrogate marker for HPV-positive OSCC.

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Section: Human Papillomavirus 16 and 18 Infection In Oral Cancer In Tmentioning

confidence: 99%

Human Papillomavirus 16 and 18 Infection in Oral Cancer in Thailand: A Multicenter Study

Komolmalai

Pongsiriwet

Lertprasertsuke

et al. 2020

Asian Pac J Cancer Prev

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“…3 Case-control studies have demonstrated strong associations between sexual behaviors and odds of HPV-related OPC (HPV-OPC). [4][5][6][7][8][9] However, these studies focused primarily on number of sexual partners without other contextual data about relationship dynamics, intensity of exposure, or order of acts at sexual debut.…”

Section: Introductionmentioning

confidence: 99%

“…Human papillomavirus (HPV) has driven an increase in incidence of oropharyngeal cancer (OPC) in the United States and other countries, 1,2 which is thought to be explained by trends in oral sexual behavior 3 . Case‐control studies have demonstrated strong associations between sexual behaviors and odds of HPV‐related OPC (HPV‐OPC) 4‐9 . However, these studies focused primarily on number of sexual partners without other contextual data about relationship dynamics, intensity of exposure, or order of acts at sexual debut.…”

Section: Introductionmentioning

confidence: 99%

Timing, number, and type of sexual partners associated with risk of oropharyngeal cancer

Drake

Fakhry

Windon

et al. 2021

Cancer

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BACKGROUND: Case-control studies from the early 2000s demonstrated that human papillomavirus-related oropharyngeal cancer (HPV-OPC) is a distinct entity associated with number of oral sex partners. Using contemporary data, we investigated novel risk factors (sexual debut behaviors, exposure intensity, and relationship dynamics) and serological markers on odds of HPV-OPC. METHODS: HPV-OPC patients and frequency-matched controls were enrolled in a multicenter study from 2013 to 2018. Participants completed a behavioral survey. Characteristics were compared using a chi-square test for categorical variables and a t test for continuous variables. Adjusted odds ratios (aOR) were calculated using logistic regression. RESULTS: A total of 163 HPV-OPC patients and 345 controls were included. Lifetime number of oral sex partners was associated with significantly increased odds of HPV-OPC (>10 partners: odds ratio [OR], 4.3 [95% CI, 2.8-6.7]). After adjustment for number of oral sex partners and smoking, younger age at first oral sex (<18 vs >20 years: aOR, 1.8 [95% CI, 1.1-3.2]) and oral sex intensity (>5 sex-years: aOR, 2.8 [95% CI, 1.1-7.5]) remained associated with significantly increased odds of HPV-OPC. Type of sexual partner such as older partners when a case was younger (OR, 1.7 [95% CI, 1.1-2.6]) or having a partner who had extramarital sex (OR, 1.6 [95% CI, 1.1-2.4]) was associated with HPV-OPC. Seropositivity for antibodies to HPV16 E6 (OR, 286 [95% CI, 122-670]) and any HPV16 E protein (E1, E2, E6, E7; OR, 163 [95% CI, 70-378]) was associated with increased odds of HPV-OPC. CONCLUSION: Number of oral sex partners remains a strong risk factor for HPV-OPC; however, timing and intensity of oral sex are novel independent risk factors. These behaviors suggest additional nuances of how and why some individuals develop HPV-OPC.

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“…Classical risk factors for HNSCC include tobacco and alcohol consumption. However, more recently, a surge in human papilloma virus (HPV)-associated oropharyngeal cancers have been reported in the US, 1 Canada 2 and UK. 3 These cancers are also affecting a much younger population without classical risk factors for HNSCC.…”

Section: Introductionmentioning

confidence: 99%

Development of a non-invasive exhaled breath test for the diagnosis of head and neck cancer

et al. 2020

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Background Improving the ability to identify early-stage head and neck squamous cell carcinoma (HNSCC) can improve treatment outcomes and patient morbidity. We sought to determine the diagnostic accuracy of breath analysis as a non-invasive test for detecting HNSCC. Methods Standardised breath samples were collected from 181 patients suspected of HNSCC prior to any treatment. A selected ion flow-tube mass spectrometer was used to analyse breath for volatile organic compounds. Diagnosis was confirmed by histopathology. A binomial logistic regression model was used to differentiate breath profiles between cancer and control (benign disease) patients based on mass spectrometry derived variables. Results In all, 66% of participants had early-stage primary tumours (T1 and T2) and 58% had regional node metastasis. The optimised logistic regression model using three variables had a sensitivity and specificity of 80% and 86%, respectively, with an AUC for ROC curve of 0.821 (95%CI 0.625–1.0) in the testing cohort. Conclusions Breath analysis for non-invasive diagnosis of HNSCC appears to be practical and accurate. Future studies should be conducted in a primary care setting to determine the applicability of breath analysis for early identification of HNSCC.

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Increased risk of oropharyngeal cancers mediated by oral human papillomavirus infection: Results from a Canadian study

Cited by 11 publications

References 41 publications

Human Papillomavirus 16 and 18 Infection in Oral Cancer in Thailand: A Multicenter Study

Human Papillomavirus 16 and 18 Infection in Oral Cancer in Thailand: A Multicenter Study

Timing, number, and type of sexual partners associated with risk of oropharyngeal cancer

Development of a non-invasive exhaled breath test for the diagnosis of head and neck cancer

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