Increased risk of pemphigoid following scabies: a population‐based matched‐cohort study

Chung, Shiu-Dong; Lin, Herng-Ching; Wang, Kuo-Hsien

doi:10.1111/jdv.12132

Cited by 19 publications

(22 citation statements)

References 30 publications

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“…The rate of BP was 0.3% in the first-ever stroke patients and 0.06% in control patients. The low incidence of BP in the control group is similar to that of the previous study [12] and the patients with neurological disorders [13]. Given the low incidence of BP, a large-scale cohort is needed to analyze the association of stroke and BP.…”

Section: Discussionsupporting

confidence: 55%

“…The autoantibodies generated in BP are specific to the transmembrane proteins (BP230 and BP180) and may not be completely responsible for the increased cytokines in atherosclerosis/endothelial dysfunction. As most BP is developed after the emergence of a neurodegenerative disease in the reported studies [2,7,9,10,12,13,14], our hypothesis may be more close to the clinical scenario in stroke patients.…”

Section: Discussionmentioning

confidence: 80%

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Increased Risk of Bullous Pemphigoid after First-Ever Stroke: A Population-Based Study

Shen

Lin

et al. 2017

Neurodegener Dis

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Background: We hypothesize that autoantibodies are induced after the blood-brain barrier is damaged by stroke and the risk of bullous pemphigoid (BP) is increased after stroke. We assess the risk of BP after first-ever stroke in a nationwide population-based cohort of first-ever stroke patients. Methods: We extracted data from the Longitudinal Health Insurance Database 2005 and identified patients with first-ever stroke as well as control patients matched for age, gender, and year of enrollment. The risk of BP in first-ever stroke patients in comparison with that in control patients was analyzed using Cox regression. Results: Of 12,607 patients with first-ever stroke, 38 (0.3%) patients developed BP in a median of 3.5 years. In the control patients, 8 persons (0.06%) had BP in a median of 3.7 years. The crude hazard ratio (HR) of BP in first-ever stroke patients was 4.83 (95% CI 2.25-10.34, p < 0.001) compared to the control group. The adjusted HR was 4.20 (95% CI 1.94-9.08, p < 0.001) after adjustments for age, gender, hypertension, diabetes, dementia, epilepsy, Parkinson disease, furosemide, and neuroleptics for stroke patients. Conclusions: The risk of BP is increased in first-ever stroke patients in a nationwide population-based cohort and this association is independent of well-known confounders of BP.

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Section: Discussionsupporting

confidence: 55%

Section: Discussionmentioning

confidence: 80%

Increased Risk of Bullous Pemphigoid after First-Ever Stroke: A Population-Based Study

Shen

Lin

et al. 2017

Neurodegener Dis

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“…The reasons for elderly predominance, we speculate, are that older individuals have increased likelihood of bedridden status and stay in nursing homes, resulting in increased risk of scabies infection. 52,53 The exact mechanisms are not fully understood yet. The lesions may involve, except the mucosa and face, the whole body including arms, legs, trunk, genitals, feet, buttocks, thighs, neck, inguinal folds, and may even be generalized; but the trunk and extremities are the most commonly involved areas.…”

Section: Discussionmentioning

confidence: 99%

Bullous Scabies

Luo¹,

Huang²,

Liu³

et al. 2016

The American Society of Tropical Medicine and Hygiene

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Scabies is a common contagious cutaneous disease and usually affects the young, characterized by polymorphous lesions that may present as burrows, pruritic papules, and inflammatory nodules. Bullous scabies (BS) is its rather rare subtype, mimicking bullous pemphigoid. We report a 15-year-old Chinese boy presenting with 1-month history of pruritic bullae on his penile skin, showing poor response to both topical steroids and systemic antihistamines, but cured by sulfur ointment alone. No recurrence occurred in the 5 years of follow-up. We also reviewed the published cases. Up to date, 44 cases, including the present, have been reported. Of them, 30 were male and 14 were female. The age range was from 1 to 89 years old, with a median age of 70.6 years. The bullous lesions may involve the arms, legs, trunk, genitals, feet, buttocks, thighs, neck, inguinal folds, and may even be generalized. Trunk and extremities are the most common involved locations. Facial or mucosa involvement had never been reported. The histological findings present as a subepidermal split with variable inflammatory infiltrate predominantly neutrophils, and eosinophilic spongiosis, or both. Eighteen of 32 patients showed positive deposition of linear-granular IgG or complement 3 alone or in various combinations, and five of 24 patients revealed circulating IgG. All the 40 cases with therapeutic details were cured by antiscabietic remedy. BS always involves the trunk and extremities. It has a predilection for elderlies and males. The treatments for BS are similar to those of classical scabies.

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“…[5] The literature also shows that BP may be triggered by infectious factors such as scabies in adult patients. [6] In addition, BP has also been shown to be associated with Coombs'-positive hemolytic anemia, membranous glomerulonephritis, ulcerative colitis, and hyperimmunoglobulin E syndrome and to develop after liver transplantation. [78]…”

Section: Discussionmentioning

confidence: 99%

Bullous pemphigoid induced by metamizole in a pediatric patient

Uçmak

İbiloğlu

2018

Indian J Dermatol

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Bullous pemphigoid (BP) is an autoimmune bullous disease commonly seen in adult population but rarely encountered in the pediatric population. Although the exact etiology of BP remains unclear, various vaccines, infectious agents, and drug use have been blamed in the etiology of BP. Here, we present a 14-year-old patient who developed BP after using metamizole and whose diagnosis was clinically and histopathologically confirmed.

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Increased risk of pemphigoid following scabies: a population‐based matched‐cohort study

Abstract: This study detected an increased risk for pemphigoid among patients suffering from scabies. Physicians treating elderly patients with a history of scabies should be alert to the development of pemphigoid.

Cited by 19 publications

References 30 publications

Increased Risk of Bullous Pemphigoid after First-Ever Stroke: A Population-Based Study

Increased Risk of Bullous Pemphigoid after First-Ever Stroke: A Population-Based Study

Bullous Scabies

Bullous pemphigoid induced by metamizole in a pediatric patient

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