Increased risk of temporomandibular joint disorders and craniofacial deformities in patients with juvenile idiopathic arthritis: a population-based cohort study

Sheng‐Kai, Kevin; Thota, Eshwar; Huang, Jing‐Yang; Wei, James Cheng‐Chung; Resnick, Cory M.

doi:10.1016/j.ijom.2022.04.007

Cited by 23 publications

(34 citation statements)

References 30 publications

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“…The presence of comorbidities was defined as a diagnosis of hypertension, hyperlipidemia, chronic liver disease, chronic kidney disease, diabetes, cardiovascular diseases ( 16 ), malignancy, chronic obstructive pulmonary disease (COPD), ischemic heart disease, stroke, and the use of corticosteroid by performing a matching ratio 1:4 of propensity score (study period usage ≥ 30 days). In our study, the comorbidities mentioned above must be diagnosed 1 year before the index date and were based on at least two outpatient visits or one admission used in the previous studies ( 17 – 25 ).…”

Section: Methodsmentioning

confidence: 99%

Risk of Autoimmune Diseases Following Optic Neuritis: A Nationwide Population-Based Cohort Study

et al. 2022

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ObjectivesOptic neuritis is (ON) is believed to be an immune-mediated disease; however, the association between optic neuritis and autoimmune diseases remains unclear. This study aimed to identify the incidence rate and adjusted hazard ratio (aHR) of autoimmune diseases in patients with optic neuritis.MethodsThis nationwide, population-based, retrospective cohort study collected patients’ data between 1999 and 2013 from the National Health Insurance Research Database in Taiwan. A total of 9,235 patients were included. Using 1:4 propensity scoring, 1,847 patients were enrolled in the optic neuritis group and 7,388 in the non-optic neuritis group according to age, sex, comorbidities, and corticosteroid use. Follow-up was started from the index date and the endpoint was a diagnosis of new-onset autoimmune diseases including, myasthenia gravis (MG), psoriatic arthritis (PsA), systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), and ankylosing spondylitis (AS).ResultsThe Kaplan-Meier curves depicted that patients with optic neuritis had a higher cumulative incidence of autoimmune diseases than patients without optic neuritis. Cox proportional hazard regression showed that patients with optic neuritis were at a high risk of autoimmune diseases (aHR: 1.40; 95% C.I., 1.05–1.87), including MG (aHR: 4.16, 95% C.I.: 1.33–12.94), SLE (aHR: 3.33, 95% C.I.: 1.24–8.97), and AS (aHR: 2.86, 95% C.I.: 1.54–5.31). Subgroup analysis provided that patients with optic neuritis aged below 65 years (aHR: 1.42, 95% C.I.: 1.03–1.96) or who were females (aHR: 1.59, 95% C.I.: 1.11–2.27) had a significantly increased risk of autoimmune diseases compared to respective controls. The use of corticosteroids reduced the risk of autoimmune diseases in patients with optic neuritis (aHR for corticosteroids non-users: 1.46, 95% C.I.: 1.03–2.07).ConclusionPatients with optic neuritis presented with a high risk of autoimmune diseases such as MG, SLE, and AS, especially patients with optic neuritis who were young or females. Corticosteroids attenuated the link between optic neuritis and subsequent autoimmune diseases.

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Section: Methodsmentioning

confidence: 99%

Risk of Autoimmune Diseases Following Optic Neuritis: A Nationwide Population-Based Cohort Study

et al. 2022

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“…Propensity score matching (18)(19)(20)(21)(22)(23)(24)(25) was used to homogenize the baseline characteristics of the two groups (26-35). To reveal the potential risk factors contributing to the pathogenesis of pSS during follow-up, we performed multiple Cox regression on selected comorbidities to estimate the adjusted hazard ratios (aHRs) of pSS and calculated the corresponding 95% confidence intervals (CIs) to ensure the precision and accuracy of the analysis.…”

Section: Discussionmentioning

confidence: 99%

Risk of primary Sjogren’s Syndrome following human papillomavirus infections: a nationwide population-based cohort study

Chen

Dong

Chang³

et al. 2022

Front. Immunol.

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IntroductionViral infection is an exogeneous factor for primary Sjogren’s syndrome (pSS). This study investigated the association between human papillomavirus (HPV) infections and pSS through a nationwide population based cohort study.MethodsPatients with HPV infections between January, 1999 and December, 2013 were included. The incidence of new-onset pSS in patients with HPV infections and non-HPV controls were derived. The multiple Cox regression model derived the risk of pSS in patients with HPV infections. Subgroup analysis and sensitivity analysis were performed to validate the association.ResultsDuring a follow-up period of 12 years, the adjusted hazard ratio (aHR) of pSS in patients with HPV infections was significantly higher than that in non-HPV controls (aHR=1.64, 95% CI=1.47-1.83, P<0.001). The risk of pSS increased with age and the risk increased by 2.64-fold (95% CI= 2.37-2.93) for those older than 45 years. The significant association between HPV infections and the risk of pSS persisted in the sensitivity analysis restricted in HPV infections that lasted over 12 months (aHR=1.63, 95%CI=1.45-1.83, P<0.0001). Subgroup analyses revealed that both male (aHR=1.83, 95%CI=1.47-2.28, P<0.0001) and female (aHR=1.58, 95%CI=1.40-1.79, P<0.0001) patients with HPV infections and HPV-infected patients aged between 16 and 45 years (aHR=1.60, 95%CI=1.34-1.91, P<0.0001) and over 45 years (aHR=1.67, 95%CI=1.46-1.91, P<0.0001) were associated with a significantly greater risk of pSS.ConclusionPatients with HPV infections presented with a significantly higher risk of pSS, regardless of age and sex.

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“…In most real-world studies on MTX for rheumatic diseases including rheumatoid arthritis, 2 ankylosing spondylitis, juvenile idiopathic arthritis, 3,4 Sjogren's syndrome, psoriasis, 5 osteoarthritis, 6 and fibromyalgia 7 , including the present study, 1 participants in most arms did not only receive MTX as a monotherapy. Instead, both groups took hydroxychloroquine (HCQ) at baseline.…”

Section: Long-term Safety and Efficacy Of Methotrexate In Patients Wi...mentioning

confidence: 83%

“…4,5,6 Center for Global Health, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA 2 Department of Epidemiology, Harvard T.H. Chan School of…”

mentioning

confidence: 99%

Long‐term safety and efficacy of methotrexate in patients with palindromic rheumatism

et al. 2022

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Increased risk of temporomandibular joint disorders and craniofacial deformities in patients with juvenile idiopathic arthritis: a population-based cohort study

Cited by 23 publications

References 30 publications

Risk of Autoimmune Diseases Following Optic Neuritis: A Nationwide Population-Based Cohort Study

Risk of Autoimmune Diseases Following Optic Neuritis: A Nationwide Population-Based Cohort Study

Risk of primary Sjogren’s Syndrome following human papillomavirus infections: a nationwide population-based cohort study

Long‐term safety and efficacy of methotrexate in patients with palindromic rheumatism

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