Increased Risk of Toxoplasma gondii Infection in Patients with Colorectal Cancer in Eastern China: Seroprevalence, Risk Factors, and a Case–Control Study

Yu, Yang; Guo, Dong; Qu, Tingting; Zhao, Shuchao; Chang, Xu; Wang, Longlong; Wang, Zhongjun; Fu, Hailing; Zhang, Xiangyan; Zhou, Na

doi:10.1155/2020/2539482

Cited by 6 publications

(10 citation statements)

References 26 publications

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“…T. gondii achieves persistence in host cells by manipulating many signaling pathways, which are closely related to immune and inflammatory responses ( 34 ), and may cause severe damage to immunodeficient or immunocompromised hosts. Epidemiology in various region surveys has shown that the seroprevalence of T. gondii is significantly increased in both elderly patients and cancer patients ( 35 , 36 ). Moreover, the other genes associated with cg11676291 MORN1 were also enriched in immune-related pathways, including the T-cell receptor signaling pathway, B-cell receptor signaling pathway, Th17 cell differentiation, and Th1 and Th2 cell differentiation.…”

Section: Discussionmentioning

confidence: 99%

Epigenome-wide gene–age interaction study reveals reversed effects of MORN1 DNA methylation on survival between young and elderly oral squamous cell carcinoma patients

Chen

et al. 2022

Front. Oncol.

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DNA methylation serves as a reversible and prognostic biomarker for oral squamous cell carcinoma (OSCC) patients. It is unclear whether the effect of DNA methylation on OSCC overall survival varies with age. As a result, we performed a two-phase gene–age interaction study of OSCC prognosis on an epigenome-wide scale using the Cox proportional hazards model. We identified one CpG probe, cg11676291MORN1, whose effect was significantly modified by age (HRdiscovery = 1.018, p = 4.07 × 10−07, FDR-q = 3.67 × 10−02; HRvalidation = 1.058, p = 8.09 × 10−03; HRcombined = 1.019, p = 7.36 × 10−10). Moreover, there was an antagonistic interaction between hypomethylation of cg11676291MORN1 and age (HRinteraction = 0.284; 95% CI, 0.135–0.597; p = 9.04 × 10−04). The prognosis of OSCC patients was well discriminated by the prognostic score incorporating cg11676291MORN1–age interaction (HRhigh vs. low = 3.66, 95% CI: 2.40–5.60, p = 1.93 × 10−09). By adding 24 significant gene–age interactions using a looser criterion, we significantly improved the area under the receiver operating characteristic curve (AUC) of the model at 3- and 5-year prognostic prediction (AUC3-year = 0.80, AUC5-year = 0.79, C-index = 0.75). Our study identified a significant interaction between cg11676291MORN1 and age on OSCC survival, providing a potential therapeutic target for OSCC patients.

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Section: Discussionmentioning

confidence: 99%

Epigenome-wide gene–age interaction study reveals reversed effects of MORN1 DNA methylation on survival between young and elderly oral squamous cell carcinoma patients

Chen

et al. 2022

Front. Oncol.

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“…Sociodemographic data (including age, residence area, and occupation) were collected from participants. Lifestyle variables, including contact with animals (cats, pigs, and/or dogs), consumption of undercooked meat, of raw vegetables or fruits, contact with soil, and source of drinking water, were obtained via a structured questionnaire ( Yu et al, 2020 ). Clinical data were collected from the participant’s medical records.…”

Section: Methodsmentioning

confidence: 99%

“…Serum samples were tested for IgG and IgM antibodies against T. gondii using enzyme-linked immunosorbent assay (ELISA) kits (Kanghua Bio, Beijing, China), as previously described ( Yu et al, 2020 ). Briefly, serum (10 μL) and sample diluent (100 μL) were mixed and dropped into a well on the plate coated with T. gondii antigen.…”

Section: Methodsmentioning

confidence: 99%

“…Humans can be infected with T. gondii by having contact with cats, eating undercooked meat, or having regular contact with soil harboring T. gondii ( Elmore et al, 2010 ; Tian et al, 2017 ; Zhou et al, 2019 ). Studies conducted by Yu and Zhou showed T. gondii to be common in cancer patients in eastern China, and that blood transfusion and chemotherapy could promote the spread of this parasite ( Zhou et al, 2018 ; Yu et al, 2020 ). Epidemiological investigation of T. gondii in cancer patients has been undertaken in recent years ( Cong et al, 2015b ; Yu et al, 2020 ).…”

Section: Introductionmentioning

confidence: 99%

“…Studies conducted by Yu and Zhou showed T. gondii to be common in cancer patients in eastern China, and that blood transfusion and chemotherapy could promote the spread of this parasite ( Zhou et al, 2018 ; Yu et al, 2020 ). Epidemiological investigation of T. gondii in cancer patients has been undertaken in recent years ( Cong et al, 2015b ; Yu et al, 2020 ). However, the seroprevalence of T. gondii in patients with a benign GT in eastern China is not known, nor indeed the potential risk factors of T. gondii infection in such patients.…”

Section: Introductionmentioning

confidence: 99%

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Seroprevalence of Toxoplasma gondii infection in women with a gynecological tumor living in eastern China

Wang

et al. 2022

PeerJ

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The association between Toxoplasma gondii (T. gondii) infection and malignancy has attracted increased attention in recent years, but little is known of T. gondii infection among women diagnosed with a gynecological tumor (GT) in China. We conducted a case-control study involving 460 women diagnosed with a GT and 460 age-matched healthy controls (HCs) to estimate the infection process of T. gondii and understand the risk factors of T. gondii infection in patients with a GT. Levels of anti-T. gondii IgG and IgM were measured by enzyme-linked immunoassays every 12 months. After a median follow-up time of 4.3 years (range 4 to 5 years), 55/460 (11.96%) patients with a GT and 15/460 (3.26%) HCs were seroprevalence for T. gondii antibodies, respectively (P = 0.001). IgG antibodies against T. gondii were found in 54 GT patients (11.74%) and 15 HCs (3.26%), respectively (P = 0.001). The seroprevalence of T. gondii IgM antibodies was similar in patients with a GT and with HCs (2.83% vs 1.3%, P = 0.105). Multivariate stepwise logistic regression analysis revealed contact with cats (OR, 6.67; 95% CI [2.89–10.75]; P = 0.001), exposure to soil (OR, 2.16; 95% CI [1.14–4.10]; P = 0.019), being a farm-worker (OR, 4.17; 95% CI [1.20–11.49]; P = 0.006) and history of chemotherapy (OR, 3.16; 95% CI [1.56–6.45]; P = 0.001) to be independent risk factors for T. gondii infection. Women with an ovarian cancer or endometrial cancer had higher T. gondii seroprevalence than that of HCs. Moreover, T. gondii infection in patients with a GT mostly acquired within two years of diagnosis, but the infection in healthy controls had no obvious time characteristics. Here, we demonstrated that T. gondii infection is significantly higher in patients with a GT (especially in women with an ovarian tumor) compared to HCs. Thus, infection with this parasite should be avoided in patients with a GT, and the causal relationship between T. gondii and GTs should be studied in detail.

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Ginsenosides attenuate bioenergetics and morphology of mitochondria in cultured PC12 cells under the insult of amyloid beta-peptide

Kwan

Huang

Dong

et al. 2020

Journal of Ginseng Research

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Background Mitochondrial dysfunction is one of the significant reasons for Alzheimer's disease (AD). Ginsenosides, natural molecules extracted from Panax ginseng , have been demonstrated to exert essential neuroprotective functions, which can ascribe to its anti-oxidative effect, enhancing central metabolism and improving mitochondrial function. However, a comprehensive analysis of cellular mitochondrial bioenergetics after ginsenoside treatment under Aβ-oxidative stress is missing. Methods The antioxidant activities of ginsenoside Rb 1 , Rd, Re, Rg 1 were compared by measuring the cell survival and reactive oxygen species (ROS) formation. Next, the protective effects of ginsenosides of mitochondrial bioenergetics were examined by measuring oxygen consumption rate (OCR) in PC12 cells under Aβ-oxidative stress with an extracellular flux analyzer. Meanwhile, mitochondrial membrane potential (MMP) and mitochondrial dynamics were evaluated by confocal laser scanning microscopy. Results Ginsenoside Rg 1 possessed the strongest anti-oxidative property, and which therefore provided the best protective function to PC12 cells under the Aβ oxidative stress by increasing ATP production to 3 folds, spare capacity to 2 folds, maximal respiration to 2 folds and non-mitochondrial respiration to 1.5 folds, as compared to Aβ cell model. Furthermore, ginsenoside Rg1 enhanced MMP and mitochondrial interconnectivity, and simultaneously reduced mitochondrial circularity. Conclusion In the present study , these results demonstrated that ginsenoside Rg 1 could be the best natural compound, as compared with other ginsenosides, by modulating the OCR of cultured PC12 cells during oxidative phosphorylation, in regulating MMP and in improving mitochondria dynamics under Aβ-induced oxidative stress.

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Increased Risk of Toxoplasma gondii Infection in Patients with Colorectal Cancer in Eastern China: Seroprevalence, Risk Factors, and a Case–Control Study

Cited by 6 publications

References 26 publications

Epigenome-wide gene–age interaction study reveals reversed effects of MORN1 DNA methylation on survival between young and elderly oral squamous cell carcinoma patients

Epigenome-wide gene–age interaction study reveals reversed effects of MORN1 DNA methylation on survival between young and elderly oral squamous cell carcinoma patients

Seroprevalence of Toxoplasma gondii infection in women with a gynecological tumor living in eastern China

Ginsenosides attenuate bioenergetics and morphology of mitochondria in cultured PC12 cells under the insult of amyloid beta-peptide

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