Increased risk of varicella-zoster virus infection in patients with breast cancer after adjuvant radiotherapy: A population-based cohort study

Lai, Yung-Chih; Su, Yuan; Kao, Chia Hung; Liang, Ji An

doi:10.1371/journal.pone.0209365

Cited by 13 publications

(21 citation statements)

References 19 publications

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“…Concerning the herpes zoster presented 2 months later, we think that it was favored by immunosuppression induced by the general steroid therapy. However, we cannot eliminate with certainty that it was not induced by radiotherapy as suggested in several articles (34,34).…”

Section: Discussionmentioning

confidence: 86%

Recurrence of pemphigus vulgaris after bilateral breast irradiation: a case report and review of the literature

Invernizzi¹,

Gaultier²,

Guilbert³

et al. 2021

Preprint

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Background Pemphigus is a serious and rare chronic bullous autoimmune disease. It is characterized by mucocutaneous erosions secondary to autoantibodies directed against desmogleins 1 and 3, proteins involved in intercellular adhesion mechanisms. The occurrence of pemphigus is based on the triggering of genetic and external environmental factors such as drugs, infection and more rarely radiotherapy. To date, only 16 cases of radiation-induced pemphigus are described in a context of breast cancer treatment. Case presentation: We present the case of a 76-year-old woman who had a recurrence of pemphigus vulgaris limited to the irradiation field after exposure to an adjuvant radiotherapy treatment for a bilateral triple negative breast cancer. The onset was bilateral limited to the irradiation area and was treated effectively with local and systemic corticosteroids. After a rigorous review of the literature, only 16 cases of breast cancer radiation-induced pemphigus appeared. In contrast to several cases, the rash was limited to the irradiated area and improved with systemic corticosteroids. Conclusions Pemphigus is a very rare side effect of radiotherapy, notably in breast cancer. For more than three-quarters of the described cases in the literature, this condition occurs within three months following the end of treatment. After systemic immunosuppressive treatment, this disease disappears in the vast majority of the reported cases.

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Section: Discussionmentioning

confidence: 86%

Recurrence of pemphigus vulgaris after bilateral breast irradiation: a case report and review of the literature

Invernizzi¹,

Gaultier²,

Guilbert³

et al. 2021

Preprint

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“…In a retrospective case series, 8.1% of patients with small‐cell lung cancer developed HZ after intensive treatment that included RT; these events frequently occurred within 1 year after the initiation of treatment 22 . In a large matched‐pair study, patients who received postoperative RT for breast cancer exhibited a 1.51‐fold higher risk of HZ than non‐RT controls; this elevated risk was observed within 5 months of RT completion 20 . A prospective cohort study investigated HZ incidence before and after a diagnosis of cancer, and the results indicated a greater risk of HZ among chemotherapy recipients who had solid organ malignancy compared with noncancer population controls (adjusted HR, 1.84; 95% CI, 1.54‐2.20) and a moderately greater risk among RT recipients (adjusted HR, 1.38; 95% CI, 1.17‐1.63) 16 .…”

Section: Discussionmentioning

confidence: 99%

“…Since the 1940s, several studies have investigated the development of HZ after radiation therapy (RT) and have described the frequency and timing of events and the clinical course; however, most of those studies were limited to cohorts of patients with a specific malignant disease and lacked robust statistical analyses 19‐24 . Some epidemiological studies investigated HZ incidence among patients with cancer and measured the effects of anticancer therapy 15,16 .…”

Section: Introductionmentioning

confidence: 99%

Radiation therapy and the risk of herpes zoster in patients with cancer

Shimizuguchi

Sekiya

Hara

et al. 2020

Cancer

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Background The role and impact of radiation therapy (RT) on the development of herpes zoster (HZ) has not been well studied. The objective of this study was to investigate the association between RT and HZ. Methods A propensity score‐matched, retrospective cohort study was conducted using institutional cancer registry data and medical records from 2011 to 2015. The risk of developing HZ in the RT and non‐RT groups was compared using a Cox proportional hazards model. Associations also were explored between the RT field and the anatomic location of HZ in patients who developed HZ after RT. The expected number of HZ events within the radiation field was calculated according to the RT received by each patient; then, this number was compared with the observed number of in‐field events. Results Of 17,655 patients, propensity score matching yielded 4350 pairs; of these, 3891 pairs were eligible for comparison. The cumulative incidence of HZ in the RT group (vs the non‐RT group) during the first 5 years after the index date was 2.1% (vs 0.7%) at 1 year, 3.0% (vs 1.0%) at 2 years, 3.4% (vs 1.3%) at 3 years, 4.1% vs 1.7% at 4 years, and 4.4% vs 1.8% at 5 years. The RT group showed a significantly higher risk of HZ than the non‐RT group (hazard ratio, 2.59, 95% CI, 1.84‐3.66). In the 120 patients who developed HZ after RT, HZ events were observed significantly more frequently within the RT field than expected (74 vs 43.8 events; P < .001). Conclusions Patients with cancer who received RT showed a significantly higher risk of HZ, which was commonly observed within the radiation field.

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“…In the study of Nouri, it was reported in patients who was treated with arsenic trioxide, VZV can reactivate and contribute myeloma and colon cancer [32]. Yo-Liang Lai declared, there was an increase in the risk of varicella-zoster virus infection in patients, suffering from breast cancer after adjuvant radiotherapy [35]. However some studies claimed VZV is able to cause Inflammatory bowel disease (IBD), or more severe disease in colon.…”

Section: Discussionmentioning

confidence: 99%

Prevalence of herpes simplex, varicella zoster and Cytomegalovirus in tumorous and adjacent tissues of patients, suffering from colorectal cancer in Iran

et al. 2019

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Background: Colorectal cancer (CRC) can be considered as a result of multiple risks factors, and the significant role of infectious ones, especially viral diseases could not be underestimated. Despite endorsed attempts to identify the accelerating effects of different herpes viridea, such as HSV-1, HSV2, VZV and CMV on the deterioration of different kinds of malignancy, the relationship between these viruses and CRC have not successfully been understood. Taking advantages of these facts, we assessed the role of these viruses on CRC progression. Methods: In this case-control study, 88 cancerous specimens and 70 their adjacent paraffin-embedded tissues from Modares Hospital between 2011 and 2019 were collected. We extracted the DNA of each tissue and investigated the presence of HSV-1, HSV2, VZV and CMV. Results: Our data indicated the presence of HSV-1 DNA in the three control samples; however, we could not find an obvious relationship between HSV2, VZV, CMV infection and this type of cancer. The presence of HSV-1 DNA in control tissues introduced HSV-1 as a probable factor for the killing of colorectal cancer cells. Conclusions: we supposed that HSV-1 can function as an inhibitor of colon cancer progresion, but it is required to studied more in order to find the role of this virus on CRC.

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Increased risk of varicella-zoster virus infection in patients with breast cancer after adjuvant radiotherapy: A population-based cohort study

Cited by 13 publications

References 19 publications

Recurrence of pemphigus vulgaris after bilateral breast irradiation: a case report and review of the literature

Recurrence of pemphigus vulgaris after bilateral breast irradiation: a case report and review of the literature

Radiation therapy and the risk of herpes zoster in patients with cancer

Prevalence of herpes simplex, varicella zoster and Cytomegalovirus in tumorous and adjacent tissues of patients, suffering from colorectal cancer in Iran

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