Increased risk of vitamin D deficiency and insufficiency in Black patients with central centrifugal cicatricial alopecia

Collins, Molly; Ali, Shaheir; Wiss, Isa Pupo; Senna, Maryanne M.

doi:10.1016/j.jaad.2022.02.018

Cited by 6 publications

(3 citation statements)

References 5 publications

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“…Vitamin D has been shown to support keratinocyte differentiation in hair follicle formation and may underscore why its deficiency has been linked to CCCA in the literature. 23 In a study by Conic et al, 30 it was found that African Americans had odds of severe vitamin D deficiency 6.3 fold greater than Caucasians, which may further support why CCCA disproportionally affects African Americans. Regardless, the association between CCCA and these comorbidities remains unclear, and it is recommended that clinicians base their screening on patients with CCCA, (such as HgA1C, lipids, blood pressure, and vitamin D levels), on a case-by-case basis.…”

Section: Discussionmentioning

confidence: 94%

“…Finally, the risk of vitamin D deficiency/insufficiency in Black women with CCCA was researched by Collins et al 23 . They performed a retrospective review of 54 Black women with CCCA, 27 of whom had a documented vitamin D level.…”

Section: Resultsmentioning

confidence: 99%

“…Significantly higher rates of hyperlipidemia in patients with CCCA (P ≤ .0001) 20 No significant association between hyperlipidemia and CCCA 21 Vitamin D insufficiency/ deficiency 1/1 1. Significantly higher risk for vitamin D insufficiency/deficiency in patients with CCCA (OR = 5.43; 95% CI [−5.43-177.63]; P = .0018) 23 CCCA, central centrifugal cicatricial alopecia; CI, confidence interval; HR, hazard ratio; OR, odds ratio; T2DM, type 2 diabetes mellitus; UF, uterine fibroids.…”

Section: Comorbidity Number Of Studies Showing Positive Association R...mentioning

confidence: 99%

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Risk factors and comorbidities associated with central centrifugal cicatricial alopecia

Green,

Feschuk,

Valdebran

2023

International Journal of Women’s Dermatology

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Central centrifugal cicatricial alopecia (CCCA) is the most common form of scarring alopecia that most often affects Black women. The disease typically begins with hair loss in the center scalp, which progresses in a centripetal fashion. Both environmental insult and genetics have been implicated in CCCA etiology, although the exact pathophysiology remains unknown. Nevertheless, it is important that providers feel comfortable educating their patients on risk factors (RFs) for the development or worsening of CCCA, and potential comorbidities associated with the condition. Thus, the goal of this review was to summarize these factors. A comprehensive literature search was performed, and studies were included if they reported research on RFs for or comorbidities associated with, CCCA. A total of 15 studies were included: n = 5 researching RFs for CCCA and n = 10 researching comorbidities associated with CCCA. There was an association suggesting an increased risk of CCCA with traction hairstyles in n = 2/3 studies, previous pregnancies in n = 1/1 studies, and use of chemical hair relaxers in n = 1/3 studies. Additionally, age and total years of hair loss were associated with increased CCCA severity in n = 2/2 studies. Type 2 diabetes was positively associated with CCCA in n = 3/5 studies, uterine leiomyomas in n = 1/2 studies, hyperlipidemia in n = 1/2 studies, and vitamin D deficiency in n = 1/1 studies. Conflicting results regarding RFs and comorbidities associated with CCCA exist within the literature. Thus, further investigation in larger cohorts must be done, and future research into genes implicated in CCCA and their potential role in the development of other diseases is recommended.

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Section: Discussionmentioning

confidence: 94%

Section: Resultsmentioning

confidence: 99%