Increased Risk of Wheeze and Decreased Lung Function after Respiratory Syncytial Virus Infection

Zomer-Kooijker, Kim; Ent, Cornelis K. van der; Ermers, Marieke J. J.; Uiterwaal, Cuno S.P.M.; Rovers, Maroeska M.; Bont, Louis

doi:10.1371/journal.pone.0087162

Cited by 102 publications

(110 citation statements)

References 28 publications

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“…RSV can be involved in upper and lower respiratory tract infections and progress to bronchiolitis and pneumonia in infants. Recent studies describe the increased risk of wheezing and asthma after RSV bronchiolitis [6].…”

Section: Introductionmentioning

confidence: 99%

Prevalence of human respiratory syncytial virus circulating in Iran

Salimi

Tavakoli-Yaraki

Yavarian

et al. 2016

Journal of Infection and Public Health

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Respiratory syncytial virus (RSV) is a leading cause of acute respiratory infection during early childhood and is associated with a great burden on patients, parents, and society. While no treatment is yet available, results from recent phase 2 clinical trials of cell-entry inhibitors and RSV vaccines are promising. To prepare for introduction of these novel therapeutics, good understanding of its molecular epidemiology and continuous RSV surveillance data are necessary. This paper provides an overview of RSV prevalence and genotype distribution in Iran from 1996 to 2013. This meta-analysis includes 21 published studies. In total, 775 (18.7%) of 4140 respiratory specimens were positive for RSV infection. The male-female ratio of RSV-positive patients was 1.5:1. Significant peaks of RSV infection were detected during the cold season (November-March). RSV infection was mainly observed in patients <2 years of age. Phylogenetic studies showed that genotypes GA1, GA2, GA5, and BA co-circulated in Iran in 2007-2013. This review highlights the necessity of introducing standard molecular surveillance programs to inform the epidemiological, clinical, and pathological characteristics of various RSV genotypes. Improved understanding of the molecular epidemiology will be useful for development of novel RSV therapeutics.

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Section: Introductionmentioning

confidence: 99%

Prevalence of human respiratory syncytial virus circulating in Iran

Salimi

Tavakoli-Yaraki

Yavarian

et al. 2016

Journal of Infection and Public Health

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“…RSV is a negative-stranded RNA virus of the paramyxoviridae family that causes bronchiolitis, wheezing, and impaired lung function in children (15) and accounts for 7.2% of hospitalizations in elderly asthmatic patients (16). Furthermore, childhood RSV infection is associated with an increased risk of developing asthma in adult life (17,18).…”

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confidence: 99%

TNF-α and Macrophages Are Critical for Respiratory Syncytial Virus–Induced Exacerbations in a Mouse Model of Allergic Airways Disease

Nguyen

Maltby

Simpson

et al. 2016

The Journal of Immunology

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Viral respiratory infections trigger severe exacerbations of asthma, worsen disease symptoms, and impair lung function. To investigate the mechanisms underlying viral exacerbation, we established a mouse model of respiratory syncytial virus (RSV)–induced exacerbation after allergen sensitization and challenge. RSV infection of OVA-sensitized/challenged BALB/c mice resulted in significantly increased airway hyperresponsiveness (AHR) and macrophage and neutrophil lung infiltration. Exacerbation was accompanied by increased levels of inflammatory cytokines (including TNF-α, MCP-1, and keratinocyte-derived protein chemokine [KC]) compared with uninfected OVA-treated mice or OVA-treated mice exposed to UV-inactivated RSV. Dexamethasone treatment completely inhibited all features of allergic disease, including AHR and eosinophil infiltration, in uninfected OVA-sensitized/challenged mice. Conversely, dexamethasone treatment following RSV-induced exacerbation only partially suppressed AHR and failed to dampen macrophage and neutrophil infiltration or inflammatory cytokine production (TNF-α, MCP-1, and KC). This mimics clinical observations in patients with exacerbations, which is associated with increased neutrophils and often poorly responds to corticosteroid therapy. Interestingly, we also observed increased TNF-α levels in sputum samples from patients with neutrophilic asthma. Although RSV-induced exacerbation was resistant to steroid treatment, inhibition of TNF-α and MCP-1 function or depletion of macrophages suppressed features of disease, including AHR and macrophage and neutrophil infiltration. Our findings highlight critical roles for macrophages and inflammatory cytokines (including TNF-α and MCP-1) in viral-induced exacerbation of asthma and suggest examination of these pathways as novel therapeutic approaches for disease management.

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“…Se ha estudiado la relación existente entre las infecciones virales en la infancia en el tracto respiratorio inferior con el desarrollo de SRRR, en particular con el virus sincitial respiratorio (VSR) y el virus parainfluenza (6,12,(14)(15)(16)(17)(18). Nuestro estudio encontró que existía una asociación entre las variables estudiadas, estimando que los niños que presentan SRRR, posteriores a los 2 años de vida, tienen 14,5 veces más probabilidad de haber tenido, al menos, un episodio de infección viral del tracto respiratorio bajo durante la infancia requiriendo hospitalización, en comparación con aquellos niños que no presentan sibilancias.…”

Section: Discussionunclassified

Asociación entre infección viral del tracto respiratorio bajo en los dos primeros años de vida y el desarrollo de sibilancias recurrentes en niños de 3 a 8 años

Goycochea-Valdivia¹,

Hidalgo-Tunque²,

Hernández-Díaz³

2016

Rev Med Hered

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RESUMENObjetivos: Determinar la asociación entre infección viral del tracto respiratorio bajo en los dos primeros años de vida con el desarrollo de sibilancias respiratorias recurrentes reversibles (SRRR), en niños. Material y métodos: Estudio caso-control incluyendo 400 niños; relación caso-control de 1:1 (α= 5%; β= 20%). Se incluyeron niños con diagnóstico de sibilancias respiratorias recurrentes reversibles que acudieron al Hospital Nacional Cayetano Heredia en los servicios de Emergencia y Consulta Externa entre mayo del 2009 y agosto del 2009, clasificándose como casos. Se asignaron 200 controles similares en edad, sexo y servicio de procedencia. Se registró el antecedente de infección viral del tracto respiratorio bajo en los dos primeros años de vida, mediante encuesta directa con los padres y corroborándose con la historia clínica de los pacientes. Resultados: Se encontró un odds ratio (OR) de 14,52 (IC 95%:6,47-32,59) para la asociación entre las variables estudiadas. Utilizando atopia familiar como parámetro de estratificación se obtuvo un OR de Mantel-Haenszel de 13,14 (IC 95%: 5,82-29,67) para la asociación entre infección viral del tracto respiratorio bajo con el desarrollo de sibilancias respiratorias. Conclusiones: Los resultados sugieren que los niños que presentan SRRR, tienen 14,52 veces más probabilidades de haber presentado infección viral del tracto respiratorio bajo en los 2 primeros años de vida, que los niños que no presentan SRRR. Esta asociación es independiente del antecedente de atopia familiar.PALABRAS CLAVE: Neumonía viral, asma, pediatría. (Fuente: DeCS BIREME). SUMMARY Objectives:To determine the association between lower viral respiratory tract infection in the first two years of life and the development of reversible recurrent respiratory wheezing (RRRW) in children. Methods: Case-control (1:1) study involving 400 children (α= 5%; β= 20%). Cases were children with RRRW who attended the emergency room

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Increased Risk of Wheeze and Decreased Lung Function after Respiratory Syncytial Virus Infection

Cited by 102 publications

References 28 publications

Prevalence of human respiratory syncytial virus circulating in Iran

Prevalence of human respiratory syncytial virus circulating in Iran

TNF-α and Macrophages Are Critical for Respiratory Syncytial Virus–Induced Exacerbations in a Mouse Model of Allergic Airways Disease

Asociación entre infección viral del tracto respiratorio bajo en los dos primeros años de vida y el desarrollo de sibilancias recurrentes en niños de 3 a 8 años

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