Increased Risks of Congenital, Neurologic, and Endocrine Disorders Associated with Autism in Preschool Children: Cognitive Ability Differences

Chen, Chuan Yu; Chen, Kuang Hung; Liu, Chieh‐Yu; Huang, Su Ling; Lin, Keh Ming

doi:10.1016/j.jpeds.2008.09.043

Cited by 19 publications

(32 citation statements)

References 32 publications

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“…Many of the clinical features reported in Table 1 have been well studied in ASD while others have not. A recent large study from Taiwan of over 3,400 children with ASD demonstrated a significant increase in the prevalence of neurological disorders, including epilepsy, disorders of the peripheral nervous system (i.e., neuropathy) and myopathies, as well as endocrine disorders, but did not provide prevalence (23). Others have reported that up to 25% of individuals with ASD eventually develop clinical seizures (24, 25).…”

Section: Clinical Features Associated With Asd Are Also Associated Wimentioning

confidence: 99%

“…Given that peripheral neuropathies are associated with abnormal electromyography studies, and that there is an increased incidence of peripheral neuropathy in ASD (23), an increased prevalence of abnormal electromyography is likely in ASD. Exercise intolerance has been found to be a common symptom of children with ASD and concomitant mitochondrial disease (13).…”

Section: Clinical Features Associated With Asd Are Also Associated Wimentioning

confidence: 99%

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Mitochondrial Dysfunction Can Connect the Diverse Medical Symptoms Associated With Autism Spectrum Disorders

2011

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Autism spectrum disorder (ASD) is a devastating neurodevelopmental disorder. Over the last decade, evidence has emerged that some children with ASD suffer from undiagnosed co-morbid medical conditions. One of the medical disorders that has been consistently associated with ASD is mitochondrial dysfunction. Individuals with mitochondrial disorders without concomitant ASD manifest dysfunction in multiple high energy organ systems, such as the central nervous, muscular and gastrointestinal systems. Interestingly, these are the identical organ systems affected in a significant number of children with ASD. This finding raises the possibility that mitochondrial dysfunction may be one of the keys that explains the many diverse symptoms observed in some children with ASD. This manuscript will review the importance of mitochondria in human health and disease, the evidence for mitochondrial dysfunction in ASD, the potential role of mitochondrial dysfunction in the co-morbid medical conditions associated with ASD, and how mitochondrial dysfunction can bridge the gap for understanding how these seemingly disparate medical conditions are related. We also review the limitation of this evidence and other possible explanations for these findings. This new understanding of ASD should provide researchers a pathway for understanding the etiopathogenesis of ASD and clinicians the potential to develop medical therapies.

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Section: Clinical Features Associated With Asd Are Also Associated Wimentioning

confidence: 99%

Section: Clinical Features Associated With Asd Are Also Associated Wimentioning

confidence: 99%

Mitochondrial Dysfunction Can Connect the Diverse Medical Symptoms Associated With Autism Spectrum Disorders

2011

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“…11 Equally concerning is that autism spectrum disorders are very frequently associated with a multitude of medical and psychiatric comorbidities at rates higher than those of typically developing children. 12 These comorbidities range from gastrointestinal, neurologic, and endocrine abnormalities 12, 13 to psychiatric comorbidities such as mood disorders, anxiety, and ADHD. 12, 14 …”

Section: Introductionmentioning

confidence: 99%

Characterization of Depression in Children With Autism Spectrum Disorders

Magnuson¹,

Constantino²

2011

Journal of Developmental &Amp; Behavioral Pediatrics

155

118

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Depressive syndromes represent a disabling comorbidity for many children with autism spectrum disorders (ASD), however the ascertainment of depression can be complicated by phenotypic overlap between the two conditions, by ways in which autistic symptomatology can mask cardinal features of depression, and by atypical manifestations of depression in children with ASD. These issues have contributed to wide variation in the estimation of prevalence rates of depression in individuals with ASD, and invoke the need for new approaches to the specific detection of depression and other neuropsychiatric comorbidities that aggregate in children affected by ASD. We review the scientific literature relevant to the occurrence of depression in ASD, and consider important parameters of risk, including psychosocial factors such as insight into affectation status, as well as biological factors such as the aggregation of depressive syndromes in certain families affected by autism, which has suggested possible overlap in genetic influences underlying the two conditions. Variability in the manifestations of depression across environmental contexts provides important clues to intervention, and underscores the potential importance of involving multiple informants in ascertaining depression in children and adolescents with ASD. A practical strategy for evaluating the presence of depression in youth with ASD is synthesized from the available data and discussed.

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“…Congenital and neurological disorders. Chen et al [76] studied 3440 children with autism and reported greatly elevated risks of congenital anomalies, like tuberous sclerosis, and neurological disorders, like epilepsy, with odds ratios of 34 and 5, respectively. The authors concluded that these disorders may provide etiological implications in autism.…”

Section: Weak Central Coherence: Integration Of Diverse Detailed Infomentioning

confidence: 99%

Update on autism: A review of 1300 reports published in 2008

Hughes¹

2009

Epilepsy & Behavior

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Increased Risks of Congenital, Neurologic, and Endocrine Disorders Associated with Autism in Preschool Children: Cognitive Ability Differences

Cited by 19 publications

References 32 publications

Mitochondrial Dysfunction Can Connect the Diverse Medical Symptoms Associated With Autism Spectrum Disorders

Mitochondrial Dysfunction Can Connect the Diverse Medical Symptoms Associated With Autism Spectrum Disorders

Characterization of Depression in Children With Autism Spectrum Disorders

Update on autism: A review of 1300 reports published in 2008

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