Increased salivary oxidative stress parameters in patients with type 2 diabetes: Relation with periodontal disease

Arana, Carlos; Fernández, Antonio J. Sánchez; Portillo, Cristóbal Morales; Serrano-Olmedo, Isabel; Mayor, M. Carmen de la Cuesta; Hernández, Tomás Martín

doi:10.1016/j.endien.2017.03.010

Cited by 25 publications

(29 citation statements)

References 22 publications

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“…However, there is evidence that the underlying upstream mechanism—oxidative stress—affects periodontal health as well (113). Low antioxidant levels are often interpreted as indicator for oxidative stress, and several studies indeed found decreased levels of antioxidants in serum, periodontal tissue, and saliva of patients with DM and periodontitis, compared to subjects without DM (114–117). One study found that the presence of T2DM in a rodent periodontitis model accelerated the decrease in gingival endothelial function (measured by Laser Doppler Flowmetry or LDF), mediated by oxidative stress (118).…”

Section: Potential Oral Complications Of Diabetes Mellitusmentioning

confidence: 99%

Evaluating All Potential Oral Complications of Diabetes Mellitus

et al. 2019

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Diabetes mellitus (DM) is associated with several microvascular and macrovascular complications, such as retinopathy, nephropathy, neuropathy, and cardiovascular diseases. The pathogenesis of these complications is complex, and involves metabolic and hemodynamic disturbances, including hyperglycemia, insulin resistance, dyslipidemia, hypertension, and immune dysfunction. These disturbances initiate several damaging processes, such as increased reactive oxygen species (ROS) production, inflammation, and ischemia. These processes mainly exert their damaging effect on endothelial and nerve cells, hence the susceptibility of densely vascularized and innervated sites, such as the eyes, kidneys, and nerves. Since the oral cavity is also highly vascularized and innervated, oral complications can be expected as well. The relationship between DM and oral diseases has received considerable attention in the past few decades. However, most studies only focus on periodontitis, and still approach DM from the limited perspective of elevated blood glucose levels only. In this review, we will assess other potential oral complications as well, including: dental caries, dry mouth, oral mucosal lesions, oral cancer, taste disturbances, temporomandibular disorders, burning mouth syndrome, apical periodontitis, and peri-implant diseases. Each oral complication will be briefly introduced, followed by an assessment of the literature studying epidemiological associations with DM. We will also elaborate on pathogenic mechanisms that might explain associations between DM and oral complications. To do so, we aim to expand our perspective of DM by not only considering elevated blood glucose levels, but also including literature about the other important pathogenic mechanisms, such as insulin resistance, dyslipidemia, hypertension, and immune dysfunction.

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Section: Potential Oral Complications Of Diabetes Mellitusmentioning

confidence: 99%

Evaluating All Potential Oral Complications of Diabetes Mellitus

et al. 2019

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“…Recent studies have used saliva sample to determine oxidative stress biomarkers related to some systemic diseases [6,7]. The clinical relevancy of saliva is based on the fact that its components can be found in plasma [8,9].…”

Section: Introductionmentioning

confidence: 99%

Validated analytical method to determine new salivary lipid peroxidation compounds as potential neurodegenerative biomarkers

Peña-Bautista

Carrascosa-Marco

Oger

et al. 2019

Journal of Pharmaceutical and Biomedical Analysis

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“…At the same time, there is a highly significant decrease (p < 0.01) in saliva of TAS in PDR patients group compared to those without PDR (Table-1). As far as saliva is concerned, a study in Spain by Arana et al [19] through measurements activity of some salivary antioxidant enzymes (glutathione peroxidase and glutathione reductase) showed that there was an increase in salivary oxidative stress parameters in patients with type 2 diabetes.…”

Section: Resultsmentioning

confidence: 99%

Oxidative Stress Status in Sera and Saliva of Type 2 Diabetic Iraqi Patients with and without Proliferative Diabetic Retinopathy

2019

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The present study aimed to look for the differences in the oxidative stress status in sera and saliva samples of type 2 diabetic Iraqi patients with and without proliferative diabetic retinopathy. As well as to look for the possibility whether this status can be measured in saliva as an alternative sample to that of serum, hence to achieve that total oxidant status, total antioxidant status and oxidative stress index were measured in both sera and saliva samples of two groups of patients with type 2 diabetes mellitus and the healthy individuals. Upon the comparison between patients without proliferative diabetic retinopathy and the control sample the results showed presence of a significant increase (p < 0.05) of total oxidant status and oxidative stress index in sera and saliva samples, while there was a significant decrease (p < 0.05) in total antioxidant status of sera and saliva samples. Meanwhile when the comparison was done between patients with proliferative diabetic retinopathy and those without proliferative diabetic retinopathy, a significant increase (p < 0.05) in both salivary total oxidant status and oxidative stress index was observed with a significant decrease (p < 0.05) in sera and salivary total antioxidant status were found in the proliferative diabetic retinopathy patients group.

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Increased salivary oxidative stress parameters in patients with type 2 diabetes: Relation with periodontal disease

Cited by 25 publications

References 22 publications

Evaluating All Potential Oral Complications of Diabetes Mellitus

Evaluating All Potential Oral Complications of Diabetes Mellitus

Validated analytical method to determine new salivary lipid peroxidation compounds as potential neurodegenerative biomarkers

Oxidative Stress Status in Sera and Saliva of Type 2 Diabetic Iraqi Patients with and without Proliferative Diabetic Retinopathy

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