Increased Scleral Rigidity and Age-related Macular Degeneration

Friedman, Ephraim; Ivry, M; Ebert, Eleanore M.; Glynn, Robert J.; Gragoudas, Evangelos S.; Seddon, Johanna M.

doi:10.1016/s0161-6420(89)32936-8

Cited by 122 publications

(76 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…A diminuição do fluxo sanguíneo da coróide e o aumento da resistência tendem a elevar a pressão hidrostática da coriocapilar aumentando o vazamento e deposição de proteínas extracelulares e lipídios, particularmente no pólo posterior, formando depósitos basais na membrana de Bruch e drusas; primeiras manifestações clínicas da DMRI (16)(17) . Na década de 80, após estudar o coeficiente de rigidez escleral de 29 pacientes com DMRI, esta teoria foi solidificada (18) .…”

Section: Discussionunclassified

Avaliação das alterações precoces na coróide e esclera ocorridas em coelhos hipercolesterolêmicos: estudo histológico e histomorfométrico

Torres¹,

Maia²,

Noronha³

et al. 2009

Arq. Bras. Oftalmol.

View full text Add to dashboard Cite

Section: Discussionunclassified

Avaliação das alterações precoces na coróide e esclera ocorridas em coelhos hipercolesterolêmicos: estudo histológico e histomorfométrico

Torres¹,

Maia²,

Noronha³

et al. 2009

Arq. Bras. Oftalmol.

View full text Add to dashboard Cite

“…Although several studies evaluated these topics, results remain controversial. [11][12][13] An established way of measuring ocular rigidity in living eyes is by injecting small-volume increments into the anterior chamber and measuring the resulting pressure change. 9 However, this is an invasive method and not suitable for everyday clinical practice.…”

Section: à3mentioning

confidence: 99%

Non-invasive biometric assessment of ocular rigidity in glaucoma patients and controls

Ebneter

Wagels

Zinkernagel

2008

Eye

View full text Add to dashboard Cite

Purpose To determine in vivo whether a pharmacologically induced change in intraocular pressure (IOP) leads to measurable changes in axial eye length and whether there is a difference between glaucoma patients and control subjects. Methods 42 subjects (19 patients with primary open angle glaucoma and 23 control patients matched for age and gender) underwent axial eye length measurement using partial coherence laser interferometry and measurement of IOP using dynamic contour tonometry before and 2 h after oral intake of 500 mg acetazolamide. Student's t-test was used to compare differences in the means. Results An identical drop in IOP was induced in both the glaucoma (mean ± SEM: 2.90 ± 0.44 mmHg, n ¼ 19) and the control group (mean±SEM: 3.17±0.32 mmHg, n ¼ 23). The change in axial eye length was significantly smaller (P ¼ 0.026) in the glaucoma group (mean±SEM: À14.2±3.2 lm, n ¼ 19) compared with the control group (mean ± SEM: À23.0 ± 2.98 lm, n ¼ 23). Conclusions Our results strongly suggest that the ocular rigidity is increased in patients with established glaucoma in comparison to control subjects. Ocular rigidity could play a role in the pathogenesis and pathophysiology of glaucoma. Determination of ocular rigidity could be helpful in detection of glaucoma.

show abstract

“…Scleral rigidity has been the subject of a series of investigations, although the majority of them were associated with the precision of intraocular pressure measurements [10][11][12]. We are unaware of any study investigating the resistance of the posterior sclera in terms of an evaluation of AL elongation in vivo.…”

Section: Introductionmentioning

confidence: 99%

The scleral rigidity of eyes with different refractions

Sergienko

Shargorogska

2012

Graefes Arch Clin Exp Ophthalmol

View full text Add to dashboard Cite

In conclusion, our study indicates that the biomechanical properties of the scleral coat, in terms of stretching and AL elongation, are measurable. The hypermetropic and emmetropic eyes possessed stiff sclera. The extent of AL remained practically unchanged during IOP elevation in these eyes. The absolute majority of the myopic eyes revealed a biomechanical weakness of the scleral shell. A higher degree of myopia was associated with increased AL elongation. Our approach to measuring the biomechanical properties of the sclera may have clinical significance in the future.

show abstract

Increased Scleral Rigidity and Age-related Macular Degeneration

Cited by 122 publications

References 10 publications

Avaliação das alterações precoces na coróide e esclera ocorridas em coelhos hipercolesterolêmicos: estudo histológico e histomorfométrico

Avaliação das alterações precoces na coróide e esclera ocorridas em coelhos hipercolesterolêmicos: estudo histológico e histomorfométrico

Non-invasive biometric assessment of ocular rigidity in glaucoma patients and controls

The scleral rigidity of eyes with different refractions

Contact Info

Product

Resources

About