Increased ROS levels in mitochondrial outer membrane protein Mul1‐deficient oocytes result in abnormal preimplantation embryogenesis
Ann Nakai,
Yuki Fukushima,
Ayaka Yamamoto
et al.
Abstract:Reactive oxygen species (ROS) are associated with oocyte maturation inhibition, and N‐acetyl‐l‐cysteine (NAC) partially reduces their harmful effects. Mitochondrial E3 ubiquitin ligase 1 (Mul1) localizes to the mitochondrial outer membrane. We found that female Mul1‐deficient mice are infertile, and their oocytes contain high ROS concentrations. After fertilization, Mul1‐deficient embryos showed a DNA damage response (DDR) and abnormal preimplantation embryogenesis, which was rescued by NAC addition and ROS de… Show more
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