Increased secretion patterns of interleukin-10 and tumor necrosis factor-alpha in cervical squamous intraepithelial lesions

Concentration levels of IL-10 and TNFαcytokines in patients with human papilloma virus (HPV) DNA+and DNA−cervical lesions

“…This outcome seems to reflect the impact and role of cervical lesions and their severity per se and also demonstrates the potential role of HPV in affecting IL-10 status (i.e., comparison of non-HPV-induced cervical lesions vs HPV + -induced lesions). Azar et al (2004) reported that, in comparison to healthy women, levels of IL-10 were statistically higher in patients with cervical lesions at the LSIL stage, while TNFα levels were higher in women at the HSIL stage. These investigators also observed that up-regulation of IL-10 secretion might have inhibited immune responses against HPV infection in early cervical lesions, whereas up-regulation of TNFα secretion likely reflected impaired/invalid responses in advanced stage lesions.…”

The paradox of IL-10-mediated modulation in cervical cancer

“…The upregulated production of IL-10 may inhibit immune responses against HPV infection in early cervical lesions, whereas upregulated TNF-α and uncoordinated cytokine production (elevated Th1 and Th2 cytokine levels) may reflect impaired or invalid responses in advanced-stage lesions. The detection of IL-10 and TNF-α in cervical secretions may be a useful indicator of local immune response and of the stage of the cervical lesions induced by HPV infection (35). The maintenance of IL-10 expression may contribute to the initiation of SIL, by allowing HPV to subvert the innate immunological surveillance and the efficient tumor escape mechanisms (2).…”

MHC loci affecting cervical cancer risk: distinguishing the effects of HLA-DQB1 and non-HLA genes TNF, LTA, TAP1 and TAP2

“…9 Some studies have shown TNF levels in the cervix to be higher in cervical cancer patients 10 and patients with high-grade lesions. 11 Other studies have been contradictory, either showing TNF to increase 12 or decrease 13 the expression of HPV16 E6/E7 RNAs, and to stimulate or suppress proliferation of transformed cervical cell lines or carcinoma cell lines. 14,15 Numerous studies have evaluated TNF as a candidate gene for cervical cancer susceptibility.…”