2013
DOI: 10.3389/fneur.2013.00028
|View full text |Cite
|
Sign up to set email alerts
|

Increased Seizure Susceptibility in Mice 30 Days after Fluid Percussion Injury

Abstract: Traumatic brain injury (TBI) has been reported to increase seizure susceptibility and also contribute to the development of epilepsy. However, the mechanistic basis of the development of increased seizure susceptibility and epilepsy is not clear. Though there is substantial work done using rats, data are lacking regarding the use of mice in the fluid percussion injury (FPI) model. It is unclear if mice, like rats, will experience increased seizure susceptibility following FPI. The availability of a mouse model… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1
1

Citation Types

3
45
0

Year Published

2014
2014
2023
2023

Publication Types

Select...
6
2

Relationship

0
8

Authors

Journals

citations
Cited by 48 publications
(48 citation statements)
references
References 31 publications
3
45
0
Order By: Relevance
“…9,21,22 This model causes a substantially different injury phenotype from the diffuse injury-only model we have used previously, with more persistent long-term deficits in motor coordination and, in a proportion of animals, post-traumatic seizures. [22][23][24] Despite these differences in long-term outcomes, we report that the acute post-injury effects are very similar in this model as in the diffuse-only model we studied previously. 18,19 This is consistent with the notion of primary injury being because of similar mechanical events during brain impact and that this is similar between different injury models.…”
Section: Introductionmentioning
confidence: 44%
See 1 more Smart Citation
“…9,21,22 This model causes a substantially different injury phenotype from the diffuse injury-only model we have used previously, with more persistent long-term deficits in motor coordination and, in a proportion of animals, post-traumatic seizures. [22][23][24] Despite these differences in long-term outcomes, we report that the acute post-injury effects are very similar in this model as in the diffuse-only model we studied previously. 18,19 This is consistent with the notion of primary injury being because of similar mechanical events during brain impact and that this is similar between different injury models.…”
Section: Introductionmentioning
confidence: 44%
“…The two injury models, however, induce very different long-term histopathologies and can produce different long-term behavioral outcomes. 9,22,71,72 The LFPI model frequently induces post-traumatic seizures, 23,24,73 which has been attributed to persistent hyperexcitability within the cortex. 74 We have demonstrated long-term cortical hyperexcitability after WDIA-induced injury, 17 but this occurs in the absence of seizure activity in this diffuse injury model.…”
Section: Similar Post-injury Cortical Effects Diverge To Produce Diffmentioning
confidence: 99%
“…Data from several laboratories show that lateral FP can trigger increased seizure susceptibility, which can be detected after administration of pentylenetetrazol (PTZ) or kainate. Lateral FPI also triggers susceptibility to seizures induced by PTZ as well as spontaneous seizures in mice [39,40].…”
Section: Epilepsy In the Fp Modelmentioning
confidence: 99%
“…11,18,19 Briefly, a 2-mm hole was drilled, with dura intact, into the skull over the left parietal cortex (anteroposterior: þ1.5 mm; mediolateral: À1.2 mm). A female luer lock was connected to the hole in the skull.…”
Section: Fpimentioning
confidence: 99%