Increased sensitivity of the obese Zucker rat to deoxycorticosterone-salt-induced hypertension

Rg, Morrison; Ab, Carpenter; Sk, Moore; Ei, Mangiarua; Ma, Valentovic; Em, Walker; Ps, Wehner; Wb, Rhoten; Rc, Touchon; Wd, McCumbee

doi:10.1097/00004872-200211000-00025

Cited by 9 publications

(6 citation statements)

References 31 publications

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“…The current study demonstrated decreased enzymatic activities of ALP and γGT in renal tissues of the diabetic group reflecting tubular dysfunction, a finding that was further documented by histopathology, where hyaline cast was present in the lumen of tubules together with coagulative necrosis of the cells. The reported tubular pathological finding corroborates those of Magil (1995) and Morrison et al (2005) who recorded a similar pathological finding in tubular damage induced by obesity in rats. Ginseng extract group exhibited near to normal histological picture, a result which was confirmed by higher renal tissue ALP and GT activities.…”

Section: Discussionsupporting

confidence: 89%

Effect of Ginseng Extract Supplementation on Renal Functions in Diabetic Rats

Sawiress¹

2011

JAS

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As incidence of diabetes is increasing worldwide, besides it is associated with complications, the present study aimed to investigate the effect of a traditional botanical, ginseng on diabetes induced alterations in kidney functions. Thirty male rats were used in the study by randomly allocating them into three groups, each of ten rats, namely the control group, diabetes group (D), and diabetes+ ginseng group (DG). The latter two groups were rendered diabetic by I/P injection of streptozotocin (50 mg/kg). Daily ginseng extract was administered orally (100 mg/kg BW), one week post streptozotocin (STZ) injection. Ninety days post STZ injection; rats were sacrificed, where serum and kidneys were obtained for determination of metabolic profile, serum electrolytes, kidney function tests, renal tissue enzymes, and renal antioxidant status, together with histopathology. The obtained results revealed a modest improvement in metabolic profile due to ginseng extract administration. However, the kidney functions were greatly improved as evidenced by amelioration of urea nitrogen, creatinine, total protein concentrations and serum electrolytes. Also an increase was noted in renal tissue enzymes and antioxidants with a decrease in malondialdehyde and renal pathology. In conclusion, ginseng extract may be of supportive treatment to combat diabetes complications.

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Section: Discussionsupporting

confidence: 89%

Effect of Ginseng Extract Supplementation on Renal Functions in Diabetic Rats

Sawiress¹

2011

JAS

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“…Contrarily, DOCA-salt treatment of obese Zucker rats increases BP in as few as 4 days. 219 Therefore, these models are suitable to explore whether obesity increases the sensitivity of animals to experimentally induced hypertension. Presumably, the involvement of the RAAS, oxidative stress, or other mechanisms may dictate the sensitivity of the models to coexisting obesity and hypertension.…”

Section: Obesitymentioning

confidence: 99%

Animal Models of Hypertension: A Scientific Statement From the American Heart Association

Lerman

Kurtz²,

Touyz³

et al. 2019

Hypertension

226

176

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Hypertension is the most common chronic disease in the world, yet the precise cause of elevated blood pressure often cannot be determined. Animal models have been useful for unraveling the pathogenesis of hypertension and for testing novel therapeutic strategies. The utility of animal models for improving the understanding of the pathogenesis, prevention, and treatment of hypertension and its comorbidities depends on their validity for representing human forms of hypertension, including responses to therapy, and on the quality of studies in those models (such as reproducibility and experimental design). Important unmet needs in this field include the development of models that mimic the discrete hypertensive syndromes that now populate the clinic, resolution of ongoing controversies in the pathogenesis of hypertension, and the development of new avenues for preventing and treating hypertension and its complications. Animal models may indeed be useful for addressing these unmet needs.

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“…It has been well documented that DOCA affects mineralocorticoid receptors and induces retention of the Na ion, causing hypertension and severe renal dysfunction with glomerular damage. 11,19,20 Furthermore, DOCA-treated rats show several types of remarkable kidney damage, including tubular dilatation, atrophy of tubular epithelial cells, and cast formation in the early stages of DOCA treatment. 11,19 In this paper, we examined the effects of SPI on severe renal dysfunction with tubular integrity using DOCA-treated Zucker rats.…”

Section: ■ Discussionmentioning

confidence: 99%

“…Few studies have evaluated the effects of SPI on the severe renal dysfunction induced by DOCA. It has been well documented that DOCA affects mineralocorticoid receptors and induces retention of the Na ion, causing hypertension and severe renal dysfunction with glomerular damage. ,, Furthermore, DOCA-treated rats show several types of remarkable kidney damage, including tubular dilatation, atrophy of tubular epithelial cells, and cast formation in the early stages of DOCA treatment. , …”

Section: Discussionmentioning

confidence: 99%

“…In this paper, we evaluated the effects of consecutive feeding of SPI on severe renal dysfunction induced by obesity and diabetes mellitus by treatment with deoxycorticosterone acetate (DOCA) salt in Zucker (fa/fa) rats, 11 which display abnormal lipid metabolism and hyperinsulinemia due to the loss of leptin receptors, resulting in mild renal dysfunction.…”

Section: ■ Introductionmentioning

confidence: 99%

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Effects of Soy Protein Isolate Feeding on Severe Kidney Damage in DOCA Salt-Treated Obese Zucker Rats

Asanoma

Tachibana

Hirotsuka

et al. 2012

J. Agric. Food Chem.

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This study assessed the effects of soy protein isolate (SPI) on severe kidney damage in deoxycorticosterone acetate (DOCA) salt-treated obese Zucker rats. These rats underwent heminephrectomy and were fed either casein or SPI diet for 12 weeks. From weeks 8 to 10 of the experiment, kidney damage was induced by biweekly injection of 25 mg/kg DOCA and administration of 0.5% NaCl (w/v) ad libitum. Urinary protein and N-acetyl-β-d-glucosaminidase excretions of SPI rats were much lower than those of casein rats at weeks 1 (p < 0.01) and 2 (p < 0.05) after DOCA treatment. Abnormal mineral excretions induced by DOCA treatment in casein rats were hardly detected in SPI rats. Severe atrophy of tubular epithelium and some flattened/detached renal tubules were also observed in casein rats, but not in SPI rats. These results indicate that consecutive treatment of SPI protects against renal dysfunction, particularly tubulointerstitial nephritis, in DOCA salt-treated obese Zucker rats.

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Increased sensitivity of the obese Zucker rat to deoxycorticosterone-salt-induced hypertension

Abstract: Results of this study indicate that obese Zucker rats are more sensitive to mineralocorticoid-induced hypertension than lean rats. This study provides experimental evidence supporting the epidemiological findings that obesity is a risk factor for the development of hypertension.

Cited by 9 publications

References 31 publications

Effect of Ginseng Extract Supplementation on Renal Functions in Diabetic Rats

Effect of Ginseng Extract Supplementation on Renal Functions in Diabetic Rats

Animal Models of Hypertension: A Scientific Statement From the American Heart Association

Effects of Soy Protein Isolate Feeding on Severe Kidney Damage in DOCA Salt-Treated Obese Zucker Rats

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