Increased sensitivity to the stimulus properties of morphine in food deprived rats

Increasing food deprivation relative to baseline influences d -amphetamine dose–response gradients

“…Results of published studies suggest that deprivation often influence stimulus control by altering the range of stimuli that evoke responding (i.e., the width of generalization gradients), by altering the evocative strength of various test stimuli differently (i.e., the height and slope of generalization gradients), and by exerting these effects in a graded fashion. While these results were obtained in all non-drug discrimination studies and in one drug-discrimination study (Gaiardi et al, 1987), three drugdiscrimination experiments failed to demonstrate statistically significant effects of deprivation on stimulus control (Li et al, 1995, Experiments 1 and 2;Massey and McMillan, 1987). The drug-discrimination studies were not specifically designed to evaluate the effects of changes in motivation on generalization gradients, however, and differed in several aspects from one another and from the studies that examined the effects of altering deprivation on stimulus control by non-drug stimuli.…”

“…Both the gradients from the Coate (1964) study and the transformed gradients yielded sigmoidal (s-shaped) gradients at higher deprivation levels (i.e., with a stronger MO in effect) and curvilinear (steeper) gradients at lower deprivation levels (i.e., with a weaker MO in effect). Interestingly, a similar pattern was also obtained in the only drug-discrimination study that demonstrated a statistically significant effect of motivation level on stimulus generalization (Gaiardi et al, 1987).…”

The role of corticosterone in food deprivation-induced reinstatement of cocaine seeking in the rat

“…This latter effect, however, was only present if rats had experienced food deprivation during cocaine self-administration training. Other studies have shown that chronic food restriction (several weeks of 30-40% of free-feeding daily ration) increases sensitivity to drug-induced lowering of threshold for BSR (Carr 1996;Cabeza de Vaca and Carr 1998) and enhances the rewarding effects of opioid and stimulant drugs, as measured by the drug self-administration (Carroll and Meisch 1984) and the conditioned place preference (Gaiardi et al 1987;Cabib et al 2000) procedures.…”

Augmentation of Heroin Seeking Following Chronic Food Restriction in the Rat: Differential Role for Dopamine Transmission in the Nucleus Accumbens Shell and Core

“…In animal models of addiction and relapse, caloric restriction reliably augments drug taking and seeking. Both acute food deprivation (complete removal) and chronic food restriction (prolonged, restricted availability) increase self-administration of a variety of substances, including opiate and psychostimulant drugs (Carroll and Meisch, 1981;Carroll and Meisch, 1984), and the conditioned rewarding properties of morphine in the conditioned place preference paradigm (CPP; Gaiardi et al, 1987;Jung et al, 2016). Recently, we found that chronic (14 days) food restriction augments heroin seeking in rats under prolonged withdrawal .…”