Increased Sensitization to Kathon CG (Methylchloroisothiazolinone plus methylisothiazolinone) in the South of Gran Canaria, Spain

Liuti, Federica; Hernández, Z.; Borrego, Leopoldo

doi:10.1016/j.adengl.2014.09.016

Cited by 2 publications

(2 citation statements)

References 7 publications

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“…In our area, sensitization to MCI/MI is common, with an epidemiologic association with use of cosmetics and working as cleaning personnel . Accordingly, we aimed to determine the degree of exposure to MCI/MI and other isothiazolinones in our patients.…”

Section: Introductionmentioning

confidence: 99%

“…5 In our area, sensitization to MCI/MI is common, with an epidemiologic association with use of cosmetics and working as cleaning personnel. 6,7 Accordingly, we aimed to determine the degree of exposure to MCI/MI and other isothiazolinones in our patients. We used liquid chromatography tandem mass spectrometry (LC-MS/MS) to analyze the concentration of isothiazolinones in cleaning products provided by our patients, and extended the study to also include products chosen randomly from the market.…”

Section: Introductionmentioning

confidence: 99%

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Isothiazolinones in cleaning products: Analysis with liquid chromatography tandem mass spectrometry of samples from sensitized patients and market

et al. 2019

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Background Methylchloroisothiazolinone (MCI) and methylisothiazolinone (MI) contact dermatitis is a severe problem. The high concentrations of these substances and other isothiazolinones such as benzisothiazolinone (BIT) and octylisothiazolinone (OIT) contained in cleaning products may cause allergic contact dermatitis in sensitized patients. Objectives To evaluate the exposure to isothiazolinones contained in cleaning products on the market and from sensitized patients, and to verify the accuracy of labeling. Methods A total of 34 cleaning products were collected (17 supplied by sensitized patients and 17 bought randomly). Analysis was made of the concentrations of MI, MCI, BIT, and OIT using liquid chromatography tandem mass spectrometry (LC‐MS/MS). Results MI and BIT were the components most frequently detected. Of all the products analyzed, 76.5% contained at least one isothiazolinone. Twelve products had an MI concentration above the permitted level for rinse‐off cosmetics. Most of them were coming into direct contact with the skin in daily use. Mislabeling occurred in eight products. Conclusions Some cleaning products with high concentrations of isothiazolinones may cause cutaneous symptoms in sensitized patients, especially in spray form. The labeling should be correct, also regarding the use of each article.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Isothiazolinones in cleaning products: Analysis with liquid chromatography tandem mass spectrometry of samples from sensitized patients and market

et al. 2019

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Mixture Toxicity of Methylisothiazolinone and Propylene Glycol at a Maximum Concentration for Personal Care Products

2018

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Methylisothiazolinone (MIT) has been used in combination with methylchloroisothiazolinone (CMIT) for cosmetic products such as shampoo, body lotion, and skin care products. The mixture of CMIT/MIT has been found to cause allergic contact dermatitis and is thus no longer permitted for use as a preservative in leave-on cosmetics. However, MIT itself was approved as a stand-alone preservative at a maximum concentration of 100 ppm as the toxicity was derived from CMIT rather than MIT. However, in many countries, allergic skin irritation caused by MIT remains a social concern. In this study, skin irritation was assessed for the presence of MIT, propylene glycol, and their mixture using a 3D human skin model EpiDerm™. Although non-diluted MIT causes serious skin toxicity, skin irritation was not observed at a concentration of 100 ppm, the maximum permissible level for cosmetics and personal care products according to European regulations. Propylene glycol, the most widely used vehicle for MIT, did not cause skin irritation in the 3D skin model. The results are expected to provide information for regulatory policies and guidelines on the use of biocides in consumer products.

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Increased Sensitization to Kathon CG (Methylchloroisothiazolinone plus methylisothiazolinone) in the South of Gran Canaria, Spain

Cited by 2 publications

References 7 publications

Isothiazolinones in cleaning products: Analysis with liquid chromatography tandem mass spectrometry of samples from sensitized patients and market

Isothiazolinones in cleaning products: Analysis with liquid chromatography tandem mass spectrometry of samples from sensitized patients and market

Mixture Toxicity of Methylisothiazolinone and Propylene Glycol at a Maximum Concentration for Personal Care Products

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