Increased sensitization to several allergens over a 12‐year period in Brazilian children

Aranda, Carolina Sánchez; Cocco, Renata Rodrigues; Pierotti, Felipe Faria; Mallozi, Márcia C.; Franco, Jackeline; Porto, Arnaldo; Goudouris, Ekaterini; Moraes, Lilian; Wandalsen, Neusa Falbo; Pastorino, Antônio Carlos; Sarinho, Emanuel Sávio Cavalcanti; Sano, Flávio; Chavarria, Maria Letícia; Borres, Magnus P.; Solé, Dírceu

doi:10.1111/pai.12860

Cited by 15 publications

(17 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Brazilian and Latin American studies are scarce. Two Brazilian multicentric studies evaluated WS in atopic patients and controls [24, 25]. The first one observed a frequency of 20.1% among atopic patients and 8.1% among controls [24]; the other study, 12 years later, observed an increase of these proportions, which were 23.4 and 9.4%, respectively [25].…”

Section: Discussion/conclusionmentioning

confidence: 99%

Celiac Disease and Sensitization to Wheat, Rye, and Barley: Should We Be Concerned?

Lanzarin¹,

Silva²,

Venturieri³

et al. 2020

Int Arch Allergy Immunol

Self Cite

View full text Add to dashboard Cite

Background: Concomitance of celiac disease (CD) and IgE-mediated wheat allergy is described in some case reports. The objective was to evaluate the frequency of sensitization to wheat, rye, barley, and malt in children and adolescents with CD. Methods: Measurement of serum levels of specific IgE to wheat, rye, barley, and malt (ImmunoCAP; sensitization IgE ≥0.35 kUA/L) in CD patients followed in specialized clinics to verify allergy history, general characteristics, small bowel biopsy characteristics, compliance with gluten-free diet (GFD), and occurrence of symptoms in case of noncompliance. Results: We evaluated 74 patients; the median of age and age at diagnosis of CD were 8.6 years (5.0–12.8) and 3.6 years (1.6–7.0), respectively. Median time of GFD was 3.5 years (1.4–5.8). History of asthma occurred in 17.3% of subjects, allergic rhinitis in 13.5%, and AD in 5.4%. Frequency of sensitization was 4% for wheat, 10.8% for rye, 5.4% for barley, and 2.7% for malt. There was no association between wheat sensitization and age at diagnosis, time of GFD, small bowel biopsy characteristics, allergy history, and gluten consumption. There was no relationship between sensitization to wheat and occurrence of immediate symptoms when not complying with GFD. Conclusion: In conclusion, the frequency of sensitization to wheat, rye, barley, and malt in CD patients was 4, 10.8, 5.4, and 2.7%, respectively. Therefore, to ensure that cutaneous and respiratory contact with wheat is safe, we advise patients with CD to investigate their sensitivity to wheat, rye, and barley because not all patients with CD are allergic to these cereals.

show abstract

Section: Discussion/conclusionmentioning

confidence: 99%

Celiac Disease and Sensitization to Wheat, Rye, and Barley: Should We Be Concerned?

Lanzarin¹,

Silva²,

Venturieri³

et al. 2020

Int Arch Allergy Immunol

Self Cite

View full text Add to dashboard Cite

show abstract

“…This was a cross-sectional study with convenience sample. The sample size was calculated from the prevalence of allergic sensitization among patients with allergy and healthy individuals, 6 with a significance of 5% associated with a 95% confidence level. The software used was PASS (Power Analysis and Sample Size) 13 -NCSS.…”

Section: Methodsmentioning

confidence: 99%

“…4,5 Household dust mites are considered the main etiological cause of respiratory allergies in our environment. 6 In spite of geographic differences, over 85% of asthma patients are located in regions of North America and South America, followed by Europe and Southeast Asia and Australia, 7 and about 90% of these patients may become sensitized to different allergens.…”

Section: Introductionmentioning

confidence: 99%

“…9 A recent national study has found that 63.9% of allergic patients are sensitized to D. pteronissynus. 6 With improvements in molecular biology, it has been possible to characterize the allergenic components of D. pteronissynus, among them those of Group 1 (Der p 1) and Group 2 (Der p 2). Der p 1 is the most abundant allergen found in mite feces and the main inducer of the IgEmediated response in patients allergic to household dust, 10 but Der p 2 is also an important allergy inducer.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Antibodies to Der p 1 and Der p 2 in allergic patients

Cruz

Ynoue

Aranda

et al. 2021

aei

Self Cite

View full text Add to dashboard Cite

Introduction and objectives: Atopic individuals are characterized by increased IgE production and Th2 response if exposed to certain antigens. It is known that the mother transfers antimite antibodies to the fetus and newborn, IgG thru the placenta, and IgA thru breastfeeding, but it is not clear whether there is a protective mechanism mediated by them concerning the development of future allergies. This study aimed to compare the levels of IgA, IgG, and IgE antibodies specific to Der p 1 and Der p 2 between atopic and healthy individuals.Methods: Serum samples of 98 patients and 44 healthy controls were subjected to quantification for specific IgE, IgG, and IgA antibodies against Der p 1 and Der p 2 by ImmunoCap® and ELISA, and subjected to statistical analysis as indicated.Results: Atopic patients had higher serum levels of IgE, IgG, and IgA specific to Der p 1 and Der p 2. The correlation was more robust between IgE and IgG antibodies.Conclusions: Allergic patients produce higher levels of antibodies against Der p 1 and Der p 2 compared with healthy individuals. The mechanisms involved still require detailed studies.

show abstract

“…10 In our study, sensitization patterns to Der p 1 and Der f 1 could not distinguish mild and severe AD patients as rBlo t 5, which shows a trend in this sense. No data were presented by Boufleur et al 11…”

mentioning

confidence: 99%

rBlo t 5 is a potential contributor to the severity of atopic dermatitis in a Brazilian population

Oliveira

Pierotti

Mallozi

et al. 2019

Pediatric Allergy Immunology

Self Cite

View full text Add to dashboard Cite

Increased sensitization to several allergens over a 12‐year period in Brazilian children

Cited by 15 publications

References 10 publications

Celiac Disease and Sensitization to Wheat, Rye, and Barley: Should We Be Concerned?

Celiac Disease and Sensitization to Wheat, Rye, and Barley: Should We Be Concerned?

Antibodies to Der p 1 and Der p 2 in allergic patients

rBlo t 5 is a potential contributor to the severity of atopic dermatitis in a Brazilian population

Contact Info

Product

Resources

About