2017
DOI: 10.1053/j.gastro.2017.03.008
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Increased Serotonin Signaling Contributes to the Warburg Effect in Pancreatic Tumor Cells Under Metabolic Stress and Promotes Growth of Pancreatic Tumors in Mice

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Cited by 219 publications
(187 citation statements)
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“…Secondly, the activation of AMPK-AKT signaling is universally known to induce mTOR signaling, demonstrating a possible mechanism for metabolic reprogramming of hepatocytes by IL-22. Thirdly, it has also been suggested that mTOR signaling activation potentiates glycolytic enzymes expression, likely HK-2, c-Myc [43]. Our findings therefore indicate a stream-lined mechanism for the molecular basis of the liver protective potentials of IL-22, where IL-22 leads to the induction of mTOR activation, causing the upregulation of glycolytic enzymes, as suggested in Fig.…”
Section: Discussionsupporting
confidence: 68%
“…Secondly, the activation of AMPK-AKT signaling is universally known to induce mTOR signaling, demonstrating a possible mechanism for metabolic reprogramming of hepatocytes by IL-22. Thirdly, it has also been suggested that mTOR signaling activation potentiates glycolytic enzymes expression, likely HK-2, c-Myc [43]. Our findings therefore indicate a stream-lined mechanism for the molecular basis of the liver protective potentials of IL-22, where IL-22 leads to the induction of mTOR activation, causing the upregulation of glycolytic enzymes, as suggested in Fig.…”
Section: Discussionsupporting
confidence: 68%
“…Western blot analysis was performed as described previously [35][36][37] . Anti-PIK3R5, N-cadherin, E-cadherin, Vimentin, MMP2, Beclin1, p62, ATG5, LC3-II, Bax, Bcl2, cleaved caspase-3, and GAPDH were purchased from Abcam (Cambridge, UK), and anti-p-AKT, AKT, p-mTOR, and mTOR were obtained from Cell Signaling Technology.…”
Section: Western Blotmentioning
confidence: 99%
“…Serotonin and 5-HTR2A agonists were found to induce melanogenesis in melanoma cell lines [9]. Jiang et al reported increased levels of serotonin and 5-HTR2B in human pancreatic ductal adenocarcinomas which promoted pancreatic tumor growth in mice [37]. Many other studies have similarly reported growth stimulatory effects of serotonin signaling through various 5-HTRs and inhibitory effects of 5-HTR antagonists in many tumor types [38,39].…”
Section: Discussionmentioning
confidence: 98%
“…However, there have also been reports, albeit much fewer, suggesting that treatment with serotonin agonists might also have anti-cancer effects in glioma [40] and breast cancer cells [41]. Involvement within the autocrine loops and activation of the MAPK, JNK, PI3K/Akt/mTOR [37,38] pathways has been implicated in serotonin's mitogenic role.…”
Section: Discussionmentioning
confidence: 99%