1994
DOI: 10.1111/j.1651-2227.1994.tb18139.x
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Increased serum antibody levels to dietary antigens in cystic fibrosis

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Cited by 5 publications
(3 citation statements)
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“…Moreover, the local overactivation of the innate immune system compromises the handling of dietary molecules, thus favouring inadequate cellular and humoral immune responses to food components. Accordingly, CF patients often exhibit increased levels of antibodies against alimentary antigens, including anti-gliadin IgA antibodies, shifts in the intestinal microbiota, elevated fecal calprotectin levels and increased intestinal permeability 17,20,47 . Moreover, the prevalence of autoantibodies against TGM2 is four times higher than in the general population, even in the absence of histological evidence of intestinal lesions 18,32,33 .…”
Section: Discussionmentioning
confidence: 99%
“…Moreover, the local overactivation of the innate immune system compromises the handling of dietary molecules, thus favouring inadequate cellular and humoral immune responses to food components. Accordingly, CF patients often exhibit increased levels of antibodies against alimentary antigens, including anti-gliadin IgA antibodies, shifts in the intestinal microbiota, elevated fecal calprotectin levels and increased intestinal permeability 17,20,47 . Moreover, the prevalence of autoantibodies against TGM2 is four times higher than in the general population, even in the absence of histological evidence of intestinal lesions 18,32,33 .…”
Section: Discussionmentioning
confidence: 99%
“…Indeed, in the CF intestine, two unfavorable events determine an inadequate cellular and humoral immune response to food components, (i) the increased antigenic load due to pancreatic insufficiency and (ii) the constitutive chronic intestinal inflammation due to loss-of function-mutations in the CF transmembrane conductance regulator (CFTR) gene [4, 5]. Accordingly, CF patients often manifest increased levels of antibodies against alimentary antigens, including anti-gliadin IgA antibodies, increased intestinal permeability, elevated levels of fecal calprotectin, shifts in the intestinal microbiota, and increased intestinal permeability [57]. Importantly, CF patients manifest a threefold increase in the prevalence of celiac disease (CD) [8, 9] a permanent intolerance to gluten/gliadin proteins that occurs in a proportion of susceptible individuals who bear the human leukocyte antigen (HLA) DQ2/DQ8 [1012].…”
Section: Introductionmentioning
confidence: 99%
“…Importantly, CF patients manifest a threefold increase in the prevalence of celiac disease (CD) [8, 9] a permanent intolerance to gluten/gliadin proteins that occurs in a proportion of susceptible individuals who bear the human leukocyte antigen (HLA) DQ2/DQ8 [1012]. Of note, a prevalence as high as ~ 4% of positive anti-TG2-IgA autoantibodies, a serological marker of CD, has been reported in several cohorts of CF patients [57], even in the absence of villous damage, the hallmark of CD. Thus, there is an epidemiological link between CF and CD.…”
Section: Introductionmentioning
confidence: 99%