Increased serum apolipoprotein(a) in patients with chronic renal failure treated with continuous ambulatory peritoneal dialysis

Increased Plasma Lipoprotein(a) in Continuous Ambulatory Peritoneal Dialysis Is Related to Peritoneal Transport of Proteins and Glucose

“…The finding of a markedly increased plasma Lp(a) level in CAPD patients is in agreement with most previous studies in CAPD patients [13][14][15][16][17][18][19][20][21][22][23][24][25][26], with just one exception 27] (table 3). The current study also pro vides support for earlier findings that Lp(a) is higher in CAPD compared to HD patients (table 3); however, the reason for this has not been established.…”

“…Hitherto only a few clinical conditions have been found to significantly affect plasma Lp(a) concentrations [5], Increased plasma levels of Lp(a) have recently been reported in patients with diabetic nephropathy [9] and in patients with the nephrotic syndrome [10][11][12], In patients with chronic renal failure, Lp(a) levels have been reported to be markedly increased in continuous ambulatory peri toneal dialysis (CAPD) patients [13][14][15][16][17][18][19][20][21][22][23][24][25][26] with only one exception [27], Also in patients on hemodialysis (HD), increased Lp(a) levels have been reported in several stud ies [19,20,24,25,[27][28][29][30][31][32][33][34][35][36][37][38], although normal levels have been reported in some cases [16,17,26], The reason for this apparent discrepancy is not known at present, al though the current lack of standardization of Lp(a) assays [39] may present a problem when comparing different studies. In most comparative studies, Lp(a) levels seem to be higher in CAPD compared to HD patients [16,17,…”

Lipoprotein (a) Levels in End-Stage Renal Failure and Renal Transplantation

“…We have already documented that patients affected by ESRF treated with HD have Lp(a) levels increased three fold in comparison with lipid-matched normal controls (respectively 31.7 vs. 9.4 mg/dl) [15]. Similar data have been reported by other authors in uremic patients treated with either HD or CAPD [16][17][18]. Also, in subjects with heavy proteinuria, Karadi et al [19] described levels of Lp(a) higher than in normal C. Present data confirm that ESRF is associated with an increase in Lp(a) levels due to uremia and not dependent on the kind of treatment ( H D or CAPD).…”

“…It has been postulated that the LDLreceptor pathway should be involved in the clearance of Lp(a) from plasma [46], but this finding was not confirmed afterwards [47,48], Our data could suggest that the kidney might have an active role in the Lp(a) metabolism. How ever, in patients on CAPD, Murphy et al [18] have postu lated that increased synthesis of Lp(a) could be also stimu lated by protein loss in dialysis fluid. Alternatively, we can also speculate that uremic plasma contains some factors affecting Lp(a) metabolism.…”

Serum Lipoprotein (a) Levels in Patients with Chronic Renal Failure – Evolution after Renal Transplantation and Relationship with Other Parameters of Lipoprotein Metabolism: A Prospective Study

“…There are very few other factors which can modify it, among them the influence of renal disease [1][2][3][4][5][6][7][8][9] or some drugs [ 16.17], Karadi et al [ 1 ] and Thomas et al [2] habe observed Lp(a) increases in patients with protein uria with and without renal failure. Other authors [3][4][5][6][7][8][9] have shown that patients with chronic renal failure treated with hemodialysis or peritoneal dialysis have higher Lp(a) con centrations than nonuremic controls. Until recently, data regarding Lp(a) serum concentration in renal transplant patients were not at our disposal.…”