Increased serum concentrations of inflammatory cytokines in type 2 diabetic patients with chronic kidney disease

Vi, Konenkov; Климонтов, Вадим Валерьевич; Myakina, Natalia E.; Tyan, N V; Фазуллина, Ольга Николаевна; Romanov, V. V.

doi:10.17116/terarkh201587645-49

Cited by 19 publications

(8 citation statements)

References 31 publications

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“…One study evaluated the serum levels of inflammatory cytokines in 64 patients with T2DM with CKD, and it was observed that patients with eGFR of 30-59 mL/min/1.73 m 2 had increased serum MIP-1α levels. This was associated with the decline in eGFR and also correlated positively with urinary albumin excretion [71]. Patients with T2DM with diagnosis of DN showed an increase in serum MIP-1β levels in CKD stages 1-2 [72].…”

Section: Plos Onementioning

confidence: 99%

Analysis of serum inflammatory mediators in type 2 diabetic patients and their influence on renal function

Araújo

Silva

et al. 2020

PLoS ONE

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To evaluate the serum concentrations of inflammatory mediators in patients with type 2 diabetes mellitus (T2DM) with or without renal alteration (RA) function. MethodsSerum samples from 76 patients with T2DM and 24 healthy individuals were selected. Patients with T2DM were divided into two groups according to eGFR (> or < 60mL/min/ 1.73m 2 ). Cytokines, chemokines and adipokines levels were evaluated using the Multiplex immunoassay and ELISA. ResultsTNFR1 and leptin were higher in the T2DM group with RA than in the T2DM group without RA and control group. All patients with T2DM showed increased resistin, IL-8, and MIP-1α compared to the control group. Adiponectin were higher and IL-4 decreased in the T2DM group with RA compared to the control group. eGFR positively correlated with IL-4 and negatively with TNFR1, TNFR2, and leptin in patients with T2DM. In the T2DM group with RA, eGFR was negatively correlated with TNFR1 and resistin. TNFR1 was positively correlated with resistin and leptin, as well as resistin with IL-8 and leptin. ConclusionIncreased levels of TNFR1, adipokines, chemokines and decrease of IL-4 play important role in the inflammatory process developed in T2DM and decreased renal function. We also suggest that TNFR1 is a strong predictor of renal dysfunction in patients with T2DM.

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Section: Plos Onementioning

confidence: 99%

Analysis of serum inflammatory mediators in type 2 diabetic patients and their influence on renal function

Araújo

Silva

et al. 2020

PLoS ONE

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“…Ранние этапы фиброзирования почек у больных СД отражает мочевая экскреция коллагена IV типа, трансформирующего фактора роста-β (TGF-β) и фактора некроза опухоли-α (ФНО-α) [35]. По мере снижения фильтрационной функции почек в плазме крови больных СД увеличивается уровень медиаторов фиброза и воспаления, в числе которых TGF-β, моноцитарный хемоаттрактантный протеин-1 (MCP-1), интерлейкин-6 [36], макрофагальный колониестимулирующий фак-тор (M-CSF), макрофагальный воспалительный протеин 1α (MIP-1α) [37]. Заметим, что диагностическое значение указанных биомаркеров ограничивает их низкая специфичность по отношению к патологии почек.…”

Section: äèàãíîñòèêà è ìîíèòîðèíãunclassified

Normoalbuminuric chronic kidney disease in diabetes

Климонтов

Korbut

2018

Terapevticheskii arkhiv

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Urinary albumin excretion (UAE) is widely used in clinical practice as indicator of diabetic kidney disease. According to the classical concept of the natural course of diabetic nephropathy, an increase in UAE usually precedes a decline in renal function. Meanwhile, a growing body of evidences indicates a high prevalence of normoalbuminuric chronic kidney disease (NA-CKD) in diabetic subjects, especially among patients with type 2 diabetes. An increase in NA-CKD prevalence can be results of improved glucose, blood pressure, and lipid control, widespread use of renin-angiotensin system blockers, and smoking cessation. It was shown that NA-CKD is more prevalent among women and is associated with arterial hypertension and coronary artery disease. The renal structure in subjects with NA-CKD is more heterogeneous when compared to patients with increased albuminuria, wherein interstitial changes and arteriolosclerosis could be the principal morphological findings, while signs of glomerulopathy may be absent. The prognostic value of NA-CKD needs to be clarified. It was shown that NA-CKD increases the risk of myocardial infarction, stroke and cardiovascular death in patients with diabetes. The search for alternative diagnostic markers for detecting of diabetic kidney disease in the absence of albuminuria, is of practical importance. The evaluations of the markers of tubular damage and interstitial fibrosis, as well as proteomic approaches, are considered as perspective diagnostic and prognostic options in NA-CKD. The study of pathogenesis, pathology, clinical course of NA-CKD in diabetic patients, as well as the development of more specific diagnostic and treatment options is a challenge for future research.

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“…Previous studies have reported that alterations in IL-10 levels are significantly associated with the urine albumin:creatinine ratio in diabetic nephropathy, which suggested that the aberrant production of inflammatory cytokines and chemokines could be the potential immunopathological mechanism of diabetic nephropathy (Wong et al, 2007). Another study reported that increased serum concentrations of inflammatory cytokines are correlated with the development of diabetic nephropathy (Konenkov et al, 2015). A few studies have reported the role of the IL-10 -592C/A, -819C/T, and -1082G/A polymorphisms in susceptibility to diabetic nephropathy, but with inconsistent results (Babel et al, 2006;Mtiraoui et al, 2009;Kung et al, 2010;Arababadi et al, 2012;Erdogan et al, 2012).…”

Section: Introductionmentioning

confidence: 97%

Association between interleukin-10 gene polymorphisms and susceptibility to diabetic nephropathy in a Chinese population

Liu

et al. 2016

Genet. Mol. Res.

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ABSTRACT. In this study, we investigated the association between the interleukin (IL)-10 -592C/A, -819C/T, and -1082G/A genetic variations and susceptibility to diabetic nephropathy in a Chinese population. The IL-10 -592C/A, -819C/T, and -1082G/A polymorphisms were genotyped in diabetic nephropathy patient and control samples by polymerase chain reaction-restriction fragment length polymorphism. The results were then statistically analyzed using SPSS 17.0. The results of the χ 2 test revealed a significant difference in the frequencies of the GG, GA, and AA genotypes of IL-10 -1082G/A between patients with diabetic nephropathy and control subjects (χ 2 = 10.03, P = 0.007). Unconditional logistic regression analysis revealed that the AA genotype of IL-10 -1082G/A significantly increased the susceptibility to diabetic nephropathy [adjusted odds ratio (OR) = 2.52, 95% confidence interval (CI) = 1.31-4.82] compared to the wild-type genotype. Moreover, the A allele of this polymorphism was associated with an increased risk of diabetic nephropathy compared to the G allele (adjusted OR = 1.51, 95%CI = 1.15-1.99). However, the IL-10 -819T/C and -592A/C genetic polymorphisms did not increase the risk of diabetic nephropathy.In conclusion, the IL-10 -1082G/A polymorphism was found to be correlated with the development of diabetic nephropathy.

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Increased serum concentrations of inflammatory cytokines in type 2 diabetic patients with chronic kidney disease

Cited by 19 publications

References 31 publications

Analysis of serum inflammatory mediators in type 2 diabetic patients and their influence on renal function

Analysis of serum inflammatory mediators in type 2 diabetic patients and their influence on renal function

Normoalbuminuric chronic kidney disease in diabetes

Association between interleukin-10 gene polymorphisms and susceptibility to diabetic nephropathy in a Chinese population

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