Increased serum delta neutrophil index levels are associated with intrahepatic cholestasis of pregnancy

Abstract

Objective: This study aims to compare the maternal serum delta neutrophil index (DNI) levels in intrahepatic cholestasis of pregnancy (ICP) and healthy pregnancies. Methods: This study consisted of a group of patients (n = 40) diagnosed with isolated ICP who gave birth in our hospital and a control group (n = 60) between December 1, 2015, and June 30, 2018. The diagnosis of ICP was made based on pruritus and elevated fasting serum bile acids and liver enzymes. Laboratory tests of both groups in the hospitalization process were retrospectively examined. Maternal and neonatal characteristics, pregnancy outcomes, and DNI values of the two groups were compared. Statistical analyses were performed using SPSS version 20. Results: Mean maternal serum DNI levels were significantly higher in women with ICP than in the control group (0.49 AE 4.8 vs -3.99 AE 3.02, p = <0.01). Receiver operating characteristic (ROC) curve analysis was used to define the DNI value where ICP can be best predicted. Conclusion: DNI, a new inflammatory marker, was found to be higher in women with ICP than in normal pregnancies.

Are serum delta neutrophil index and other inflammatory marker levels different in hyperemesis gravidarum?

“…There are also studies on DNI values in obstetric pathologies. Increased DNI levels were also found in obstetric patients with gestational diabetes, PPROM, preeclampsia, and intrahepatic cholestasis of pregnancy 26–29 . In a study on placenta previa, maternal DNI levels were significantly higher in placenta previa patients compared to the control group.…”

“…This system is a flow cytometry‐based hematologic analyzer using two independent white blood cell counting methods, including a myeloperoxidase (MPO) channel and a lobularity/nuclear density channel. DNI is an inflammatory marker calculated by a flow cytometry‐based hematological analyzer using the following formula: DNI (%) = (the leukocyte subfraction assayed in the MPO channel by cytochemical reaction) − (the leukocyte subfraction assayed using the nuclear lobularity channel by reflected light beam measurements) 29 . SII was calculated and recorded with the formula (neutrophil × platelet/lymphocyte).…”

“…DNI levels were also investigated in obstetric patients with gestational diabetes, preterm premature rupture of membranes (PPROM), preeclampsia, and intrahepatic cholestasis of pregnancy 26–29 . DNI may be a helpful marker in predicting the placental inflammatory response in patients with PPROM 26 .…”

Systemic immune‐inflammation index to predict placenta accreta spectrum and its histological subtypes

“…Considering the high prevalence of PP and the adverse outcomes of placental invasion that often accompany PP, diagnostic tools that are more accessible and easily applicable, less expensive, and less reliant on experience have become a topic of interest. Markers of systemic inflammatory response obtained from complete blood count parameters are used to predict overall morbidity and mortality in inflammatory‐related disorders and some types of cancer 10–13 . The similarity between the invasion patterns of trophoblasts and that of cancer cells has raised the possibility of using these markers to diagnose PAS.…”

“…Markers of systemic inflammatory response obtained from complete blood count parameters are used to predict overall morbidity and mortality in inflammatory-related disorders and some types of cancer. [10][11][12][13] The similarity between the invasion patterns of trophoblasts and that of cancer cells has raised the possibility of using these markers to diagnose PAS. Markers such as neutrophilto-lymphocyte ratios (NLR), platelet-to-lymphocyte ratios (PLR), mean platelet volume (MPV), platelet distribution width (PDW), and red blood cell distribution width (RDW) have been extensively studied for this purpose.…”