Increased serum ferritin is common in men with essential hypertension

Piperno, Alberto; Trombini, Paola; Gelosa, M.; Mauri, Viviana; Pecci, Valeria; Vergani, Anna; Salvioni, Alessandra; Mariani, Raffaella; Mancia, Giuseppe

doi:10.1097/00004872-200208000-00013

Cited by 161 publications

(118 citation statements)

References 29 publications

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“…There is also increasing evidence of a relationship between MS, individual MS components, insulin resistance and type 2 diabetes on the one hand, and, on the other, high levels of iron deposits as measured by the concentration of the acute phase reactant ferritin in serum (Merkel et al, 1988;Dmochowski et al, 1993;Fernandez-Real et al, 1998;Salonen et al, 1998;Gillum, 2001;Piperno et al, 2002;Sheu et al, 2003;Jehn et al, 2004;Jiang et al, 2004), although the nature of this relationship is far from completely elucidated. For example, while elevation of ferritin levels seems clearly to precede the development of diabetes (Gillum, 2001;Jiang et al, 2004), the temporal relationship with MS is less clear (Jehn et al, 2004).…”

Section: Discussionmentioning

confidence: 99%

Metabolic syndrome, insulin resistance and the inflammation markers C-reactive protein and ferritin

et al. 2006

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Background: Patients with metabolic syndrome (MS) have above-average risk of developing atherosclerosis and cardiovascular disease. Inflammation plays a key role in the development of atherosclerosis. High levels of the acute phase reactants C-reactive protein (CRP) and ferritin have been reported to correlate with various components of MS. Patients and methods: The serum CRP, ferritin, glucose, insulin, triglycerides, HDL-cholesterol and total cholesterol concentrations of 598 obese or overweight patients were determined, together with relevant anthropometric parameters. Insulin resistance was evaluated by the HOMA method. MS was diagnosed using the ATP III criteria. Results: CRP levels were higher among patients with central obesity than in those without (5.8 vs 3.9 mg/l; P ¼ 0.003), and higher among those with fasting plasma glucose concentrations X110 mg/dl than in those with lower concentrations (7.4 vs 4.1 mg/l; P ¼ 0.01). Serum ferritin levels were higher among patients with triglyceride concentrations X150 mg/dl than in those with lower levels (76.8 vs 40.1 ng/ml; Po0.001), and higher among those with fasting plasma glucose concentrations X110 mg/dl than in those with lower concentrations (75.7 vs 41.7 ng/ml; P ¼ 0.005). The number of MS criteria that were satisfied increased with CRP and ferritin levels. Patients with insulin resistance also had higher CRP and ferritin levels than those without, 7.3 vs 4.3 mg/l for CRP (P ¼ 0.032) and 124.5 vs 80.1 ng/ml for ferritin (Po0.001). Conclusions: MS and insulin resistance are associated with elevated serum CRP and ferritin. Evaluation of subclinical chronic inflammation in patients with MS and/or insulin resistance by determination of these markers might aid in their evaluation as candidates for aggressive intervention against cardiovascular risk factors.

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Section: Discussionmentioning

confidence: 99%

Metabolic syndrome, insulin resistance and the inflammation markers C-reactive protein and ferritin

et al. 2006

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“…To date, little is known about the regulation of iron homeostasis in hypertensive patients. Piperno et al have reported that increased serum ferritin was more frequent in subjects with essential hypertension than in normotensive subjects (31). In their study, increased resistance appeared to be among the possible mechanisms underlying iron overload in an animal model of hypertension (32).…”

Section: Fig 3 Quantification Of the Expression Of Iron Metabolism-mentioning

confidence: 94%

Angiotensin II-Induced Regulation of the Expression and Localization of Iron Metabolism-Related Genes in the Rat Kidney

et al. 2007

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“…21 High ferritin levels have been associated with established conventional risk factors like DM and HTN by various authors. [22][23][24] Reduced extraction of hepatic with increasing iron stores leading to peripheral hyperinsulinaemia was the proposed mechanism for DM 25 and pronounced metabolic alteration is the proposed mechanism for high ferritin in hypertensives. 24 Significant association of LDL cholesterol and ferritin was also reported previously.…”

Section: Variablementioning

confidence: 99%

“…[22][23][24] Reduced extraction of hepatic with increasing iron stores leading to peripheral hyperinsulinaemia was the proposed mechanism for DM 25 and pronounced metabolic alteration is the proposed mechanism for high ferritin in hypertensives. 24 Significant association of LDL cholesterol and ferritin was also reported previously. 9,26 Presence of iron accelerates oxidation of polyunsaturated fatty acids in LDL and it is the possible explanation given by authors.…”

Section: Variablementioning

confidence: 99%

Serum ferritin—a novel risk factor in acute myocardial infarction

Holay

Choudhary

Suryawanshi

2012

Indian Heart Journal

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Objectives: To study the relationship of serum ferritin with acute myocardial infarction (AMI) in univariate and multivariate analysis and to assess the relationship of high serum ferritin with established conventional risk factors.Methods: Hospital based case-control study of 75 cases of AMI, and 75 age and equal number of age, and gender-matched controls without having AMI in the age group of 30-70 years.Results: Median serum ferritin levels were significantly higher in cases (220 μg/L) than controls (155 μg/L) (P ≤ 0.0001. In univariate analysis in addition to ferritin > 200 μg/L (odds ratio [OR] 6.71, 95% confidence interval [CI] = 3.22-12.89, P < 0.05), diabetes (OR = 7.68, 95% CI = 2.95-19.13, P < 0.05), hypertension (HTN) (OR = 2.36, 95% CI = 1.02-5.14, P < 0.05) high-density lipoprotein (HDL) < 35 mg/dL (OR = 11.9, 95% CI = 2.66-52.57, P < 0.05) and smoking (OR = 2.17, 95% CI = 1.12-3.87, P < 0.05) were found to be significantly associated with AMI. After controlling for all conventional risk factors, in multiple logistic regression analysis, high ferritin was significantly associated with AMI. (adjusted OR = 5.72, 95% CI = 2.16-15.17, P < 0.001). Serum ferritin was significantly higher in diabetics than non-diabetics (P < 0.01). Conclusion:High serum ferritin is strongly and independently associated with AMI.

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Increased serum ferritin is common in men with essential hypertension

Cited by 161 publications

References 29 publications

Metabolic syndrome, insulin resistance and the inflammation markers C-reactive protein and ferritin

Metabolic syndrome, insulin resistance and the inflammation markers C-reactive protein and ferritin

Angiotensin II-Induced Regulation of the Expression and Localization of Iron Metabolism-Related Genes in the Rat Kidney

Serum ferritin—a novel risk factor in acute myocardial infarction

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